Systems, apparatuses, and methods for electroporation ablation therapy are disclosed, with a protection device for protecting electronic circuitry, devices, and/or other components from induced currents and voltages generated during a cardiac ablation procedure. A system can include an ablation device near cardiac tissue of a heart. The system can further include a signal generator configured to generate a pulse waveform, where the signal generator coupled to the ablation device and configured to repeatedly deliver the pulse waveform to the ablation device in synchrony with a set of cardiac cycles of the heart. The system can further include a protection device configured to suppress induced current and voltage in an electronic device coupled to the protection device.

Systems, apparatuses, and methods for electroporation ablation therapy are disclosed, with a protection device for protecting electronic circuitry, devices, and/or other components from induced currents and voltages generated during a cardiac ablation procedure. A system can include an ablation device near cardiac tissue of a heart. The system can further include a signal generator configured to generate a pulse waveform, where the signal generator coupled to the ablation device and configured to repeatedly deliver the pulse waveform to the ablation device in synchrony with a set of cardiac cycles of the heart. The system can further include a protection device configured to suppress induced current and voltage in an electronic device coupled to the protection device.

The invention encompasses systems and methods that allow a clinician who is untrained in the art of electroencephalography to insert and functionalize unitized intracranial electrode arrays at the bedside that, by specific design, position ground and reference electrodes in electrically quiet locations to record durable, high-fidelity intracortical EEG.

The invention encompasses systems and methods that allow a clinician who is untrained in the art of electroencephalography to insert and functionalize unitized intracranial electrode arrays at the bedside that, by specific design, position ground and reference electrodes in electrically quiet locations to record durable, high-fidelity intracortical EEG.

An ambulatory cardiac device for improving a signal to noise profile of an electrocardiogram (ECG) signal of a patient is provided. The ambulatory cardiac device includes a plurality of active ECG electrodes disposed in a plurality of locations about a patient. Each active electrode can include an ECG electrode substrate configured to be in physical contact with skin of the patient, a local biasing substrate proximate to the ECG electrode substrate and configured to be in physical contact with the skin of the patient, and local biasing circuitry configured to provide a local biasing signal into a body of the patient via the local biasing substrate.

An ambulatory cardiac device for improving a signal to noise profile of an electrocardiogram (ECG) signal of a patient is provided. The ambulatory cardiac device includes a plurality of active ECG electrodes disposed in a plurality of locations about a patient. Each active electrode can include an ECG electrode substrate configured to be in physical contact with skin of the patient, a local biasing substrate proximate to the ECG electrode substrate and configured to be in physical contact with the skin of the patient, and local biasing circuitry configured to provide a local biasing signal into a body of the patient via the local biasing substrate.

The present disclosure provides a neuromodulation device that comprises at least one amplifier circuit that suppresses a common mode (CM) voltage signal in the input voltage signal. The amplifier circuit comprises an input stage to receive the input voltage signal, and a differential transconductor to provide an output current signal based on a DM voltage signal in the input voltage signal. The transconductor is provides a first CM voltage signal tapped after a non-inverting input, and a second CM voltage signal tapped after am inverting input, to CM amplifier of the amplifier circuit. The CM amplifier combines the first CM voltage signal with the second CM voltage signal, amplifies the combined CM voltage signal with an inverting gain, and provides the inverted CM voltage signal back to the non-inverting input and the inverting input of the transconductor for enabling the CM suppression.

The present disclosure describes various systems and methods of adaptively taking bio-potential measurements of within a changing environments. Specifically, the systems and methods are directed to adaptive control of a bio-potential measurement device thereby enabling the use of the bio-potential measurement device within environments having different noise sources, such as environments with and without a device generating strong magnetic fields. Through adaptive measures, the systems and methods of the present disclosure improve the usage of a right leg drive by adaptively changing the nature of the drive itself according to its present environment (e.g., MR vs. non-MR environment). In addition to improvements in common mode rejection (CMR), the systems and methods of the present disclosure can reduce the required analog front-end dynamic range.

The present disclosure describes various systems and methods of adaptively taking bio-potential measurements of within a changing environments. Specifically, the systems and methods are directed to adaptive control of a bio-potential measurement device thereby enabling the use of the bio-potential measurement device within environments having different noise sources, such as environments with and without a device generating strong magnetic fields. Through adaptive measures, the systems and methods of the present disclosure improve the usage of a right leg drive by adaptively changing the nature of the drive itself according to its present environment (e.g., MR vs. non-MR environment). In addition to improvements in common mode rejection (CMR), the systems and methods of the present disclosure can reduce the required analog front-end dynamic range.

Certain embodiments described herein relate to a system for use in analyzing neural activity of nerves surrounding a biological lumen. The system includes a probe body, electrodes, a stimulator, and an amplifier. The stimulator delivers electrical stimulation via a first pair of the electrodes, supported by the probe body, to test for an evoked neural response by nerves surrounding the biological lumen. The amplifier includes a pair of input terminals, an output terminal, and a ground reference terminal. A second pair of the electrodes is electrically coupled to the pair of input terminals of the amplifier, to thereby enable the amplifier to produce the sensed signal indicative of the evoked neural response. A remaining one of the electrodes, which is not included in the first and the second pairs of the electrodes, is electrically coupled to the ground reference terminal of the amplifier.