A body worn patient monitoring device includes a flexible substrate having a plurality of electrical connections adapted to be coupled to a skin surface to measure physiological signals. The flexible substrate is adapted to be directly and non-permanently affixed to a skin surface of a patient and configured for single patient use. A communication-computation module, removably attached to an upper surface of the flexible substrate, is configured to receive physiological signals from the flexible substrate and includes a microprocessor that is configured to process and analyze the physiological signals. A series of resistive traces screened onto the flexible substrate are configured as at least one series current-limiting resistor to protect the communication-computation module.

Apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus may include a neural input signal acquisition module having a front-end block configured to amplify the potential difference of its input signals (V.sub.1a, V.sub.2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four calculations. The present system can automatically sense train of four response of a patient and reduce the likelihood of false train of four indications.

Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four calculations. The present system can automatically sense train of four response of a patient and reduce the likelihood of false train of four indications.

This disclosure relates to integrated channel integrity detection and to reconstruction of electrophysiological signals. An example system includes a input channels configured to receive respective electrical signals from respective electrodes. An amplifier stage includes a plurality of differential amplifiers, each of the differential amplifiers being configured to provide an amplifier output signal based on a difference between a respective pair of the electrical signals. Channel detection logic is configured to provide channel data indicating an acceptability of each of the input channels based on an analysis of a common mode rejection of the amplifier output signals.

A system for wirelessly obtaining physiological data from a subject includes a sensor patch and a separate electronics package. The sensor patch is disposed on and adheres to the subject, and includes a first part of a releasable electrical connector. An electronics package includes a second part of the first releasable electrical connector, which is used to physically and electrically connect the electronics package to the sensor patch. The electronics package includes a flexible substrate, with shells set on this substrate. The shells enclose the electronics. The shells are connected by a flexible circuit board. Analog front end circuitry is placed in one shell, while the wireless transceiver is placed in the other shell.

A system for wirelessly obtaining physiological data from a subject includes a sensor patch and a separate electronics package. The sensor patch is disposed on and adheres to the subject, and includes a first part of a releasable electrical connector. An electronics package includes a second part of the first releasable electrical connector, which is used to physically and electrically connect the electronics package to the sensor patch. The electronics package includes a flexible substrate, with shells set on this substrate. The shells enclose the electronics. The shells are connected by a flexible circuit board. Analog front end circuitry is placed in one shell, while the wireless transceiver is placed in the other shell.

Embodiments provide a method and system for using a reconstructed or virtual reference point for electrocardiogram (ECG) measurements, allowing for the removal of the common reference point required in conventional ECG systems. Embodiments allow for either referencing measurements back to a reference previously digitized and reconstructed in the analog domain or to compare the measurements to a virtual reference. These calculations can be performed at the measurement site or remotely. Vector calculations can be made in either the analog or digital domains. A secondary means of measuring common mode noise (or rejection) injected into the ECG may be provided to ensure proper functioning in the presence of large common mode noise. These secondary measurements may be used to phase-align segments of the ECG vectors or as means to improve the common mode noise capabilities.

An ECG signal acquisition system includes a first amplifier which has a non-inverting input adapted to be coupled to a first differential input, an inverting input adapted to be coupled to a second differential input, and an output. The system includes first and second biasing resistors coupled between the non-inverting and inverting inputs of the first amplifier. The system includes an average estimation circuit which has a first input coupled to the non-inverting input of the first amplifier and a second input coupled to the inverting input of the first amplifier. The system includes a driver amplifier which has an inverting input coupled to the output of the average estimation circuit, a non-inverting input coupled to receive a reference common-mode voltage, and an output. The system includes a low-pass filter coupled between the output of the driver amplifier and the biasing resistors.

The embodiments of the present disclosure are for a signal processing circuit. The signal processing circuit includes an analog circuit. The analog circuit is used for processing an initial signal it receives. The initial signal includes a target signal and a noise signal. The analog circuit includes a first processing circuit and a second processing circuit. The first processing circuit is used to increase a ratio of the target signal to the noise signal, and output a first processed signal. The second processing circuit is used to amplify the first processed signal. A gain multiple of the second processing circuit to the first processed signal varies with a frequency of the first processed signal. The first processing circuit includes a common mode signal suppression circuit used to suppress a common mode signal in the initial signal, a low-pass filter circuit, and a high-pass filter circuit.