Specific parameter sets are provided that makes the transcranial focused ultrasound to selectively activate a certain neuronal type at cortical brain and enables the transcranial focused ultrasound to non-invasively induce long-term effects at deep brain. A type of ultrasound collimator with incidence angle control is designed and validated through acoustic field pressure mapping in order to target brain areas at different depths. Multi-elements transducer arrays are also used to achieve transmission of focused ultrasound.

Specific parameter sets are provided that makes the transcranial focused ultrasound to selectively activate a certain neuronal type at cortical brain and enables the transcranial focused ultrasound to non-invasively induce long-term effects at deep brain. A type of ultrasound collimator with incidence angle control is designed and validated through acoustic field pressure mapping in order to target brain areas at different depths. Multi-elements transducer arrays are also used to achieve transmission of focused ultrasound.

Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.

A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided.

A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided.

A sleeping mask includes a signal processor for processing sensor data, an infrared light source coupled to the signal processor and configured to emit infrared light toward an eyelid of a user, and an array of infrared sensors coupled to the signal processor and configured to receive infrared light reflected from the eyelid of the user.

The present invention provides a neurological disorders decision support system that can assist an examiner to diagnose an examinee. The neurological disorders decision support system includes a user module, a screening module, an intelligent calculation module and a diagnosis module. The user module sends an inquiry to the examinee, receives a response message from the examinee, and retrieves a physiological characteristic signal of the examinee. The screening module executes a neurological examination application program to indicate to the examinee to obtain physiological characteristic signals. The screening module outputs response messages and physiological characteristic signals for the intelligent calculation module to execute an algorithm to generate an analysis report. The analysis report assists the examiner for diagnosis, and sends a diagnosis notification to the user module through the diagnosis module. The invention also provides a neurological disorders decision support method.

The present invention provides a neurological disorders decision support system that can assist an examiner to diagnose an examinee. The neurological disorders decision support system includes a user module, a screening module, an intelligent calculation module and a diagnosis module. The user module sends an inquiry to the examinee, receives a response message from the examinee, and retrieves a physiological characteristic signal of the examinee. The screening module executes a neurological examination application program to indicate to the examinee to obtain physiological characteristic signals. The screening module outputs response messages and physiological characteristic signals for the intelligent calculation module to execute an algorithm to generate an analysis report. The analysis report assists the examiner for diagnosis, and sends a diagnosis notification to the user module through the diagnosis module. The invention also provides a neurological disorders decision support method.

A wearable device includes one or more sensors of information from a subject. The wearable device may have an electronic assembly supported by a base. The electronic assembly may include a sensor data collection system configured to control collection of sensor data related to one or more characteristics of a subject and one or more processors. the sensor data collection system may include a controller configured to control sequencing and scheduling of the sensor data collection, and a buffer configured to receive and buffer data corresponding to the sensor data collected from the one or more sensors in accordance with a signal provided by the controller. The one or more processors may be configured to receive the buffered data from the buffer in accordance with a wake signal; process the received data; and output the processed data. Scheduling and sequencing the sensor data collection by the sensor data collection system may be decoupled from the processor such that the processor may be in a low-power sleep mode during data collection and in a normal power mode to process data received from the buffer.

A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.