A wearable computing device with bio-signal sensors and a feedback module provides an interactive mediated reality (“VR”) environment for a user. The bio-signal sensors receive bio-signal data (for example, brainwaves) from the user and include bio-signal sensors embedded in a display isolator, having a deformable surface, and having an electrode extendable to contact the user's skin. The wearable computing device further includes a processor to: present content in the VR environment via the feedback module; receive bio-signal data of the user from the bio-signal sensor; process the bio-signal data to determine user states of the user, including brain states, using a user profile; modify a parameter of the content in the VR environment in response to the user states of the user. The user receives feedback indicating the modification of the content via the feedback module.

A system for monitoring includes: multiple EEG sensors spatially positioned on a layer of tissue for capturing EEG signals of a patient; multiple amplifiers coupled with the EEG sensors for amplifying the captured signals; and a low frequency oscillator for generating a synchronizing signal which is distributed to the amplifiers for synchronizing the digitization of the captured signals; wherein each amplifier includes: a voltage controlled oscillator for an adjustable frequency reference; an analog to digital converter for converting the amplified signal to a digital value; and a microcontroller for controlling the frequency of the voltage controlled oscillator and operation of the analog to digital converter by using the synchronizing signal.

A system for monitoring includes: multiple EEG sensors spatially positioned on a layer of tissue for capturing EEG signals of a patient; multiple amplifiers coupled with the EEG sensors for amplifying the captured signals; and a low frequency oscillator for generating a synchronizing signal which is distributed to the amplifiers for synchronizing the digitization of the captured signals; wherein each amplifier includes: a voltage controlled oscillator for an adjustable frequency reference; an analog to digital converter for converting the amplified signal to a digital value; and a microcontroller for controlling the frequency of the voltage controlled oscillator and operation of the analog to digital converter by using the synchronizing signal.

A method of medical imaging including receiving k-space data that is divided into multiple k-space data groups, selecting one of the multiple k-space data groups as a reference k-space data group, and calculating spatial transform data for each of the multiple k-space data groups by inputting the multiple k-space data groups and the reference k-space data group into a transformation estimation module. The spatial transformation estimation module is configured for outputting spatial transform data descriptive of a spatial transform between a reference k-space data group and multiple k-space data groups in response to receiving the reference k-space data group and the multiple k-space data groups as input. The method further comprises reconstructing a corrected magnetic resonance image according to the magnetic resonance imaging protocol using the multiple k-space data groups and the spatial transform data for each of the multiple k-space data groups.

A detection apparatus is for detecting interference on signal paths in a differential voltage measuring system with a signal measuring circuit for measuring bioelectric signals with a number of useful signal paths having at least one shield. In an embodiment, the detection apparatus includes at least one analysis unit, connected to the shield and embodied to detect interference in a useful signal path of the voltage measuring system via a signal measured at the shield in the case of interference.

A detection apparatus is for detecting interference on signal paths in a differential voltage measuring system with a signal measuring circuit for measuring bioelectric signals with a number of useful signal paths having at least one shield. In an embodiment, the detection apparatus includes at least one analysis unit, connected to the shield and embodied to detect interference in a useful signal path of the voltage measuring system via a signal measured at the shield in the case of interference.

A method of deriving depth EEG data from non-invasive 2D EEG data is described. The method receives several EEG scalp signals, each of which is produced by a contact of an EEG recording device. The method converts each EEG scalp signal into multiple frequency band signals. The method identifies a set of contacts that have similar signal fragments in frequency band signals for a particular frequency band. The method determines relative time delay in frequency band signal arrival at the set of contacts. The method determines relative radius of sphere for the set of contacts based on the relative time delay in frequency band signal arrival at the set of contacts. The method then determines a signal source location by performing trilateration on the set of contacts using locations of the set of contacts and the relative radius of sphere for the set of contacts.

A method of deriving depth EEG data from non-invasive 2D EEG data is described. The method receives several EEG scalp signals, each of which is produced by a contact of an EEG recording device. The method converts each EEG scalp signal into multiple frequency band signals. The method identifies a set of contacts that have similar signal fragments in frequency band signals for a particular frequency band. The method determines relative time delay in frequency band signal arrival at the set of contacts. The method determines relative radius of sphere for the set of contacts based on the relative time delay in frequency band signal arrival at the set of contacts. The method then determines a signal source location by performing trilateration on the set of contacts using locations of the set of contacts and the relative radius of sphere for the set of contacts.

A system and method for brainwave entrainment using virtual objects and gamification, in which brainwave entrainment is applied using some combination of gaming elements, brainwave is enhanced by virtue of the user's active participation, and long-term use is encouraged by virtue of the entertaining nature of the gamification. Depending on configuration, the system and method may comprise a display comprising virtual objects, a light-producing device (other than the display), an audio-producing device such as speakers or headphones, a haptic feedback device such as a vibratory motor, a means for monitoring the user's attention, and a software application which applies brainwave entrainment using some combination of the display, the light-producing device, the audio-producing device, and the haptic feedback device.

A system and method for brainwave entrainment using virtual objects and gamification, in which brainwave entrainment is applied using some combination of gaming elements, brainwave is enhanced by virtue of the user's active participation, and long-term use is encouraged by virtue of the entertaining nature of the gamification. Depending on configuration, the system and method may comprise a display comprising virtual objects, a light-producing device (other than the display), an audio-producing device such as speakers or headphones, a haptic feedback device such as a vibratory motor, a means for monitoring the user's attention, and a software application which applies brainwave entrainment using some combination of the display, the light-producing device, the audio-producing device, and the haptic feedback device.