Provided are methods of inhibiting spreading depolarization in a subject by administering a sigma-1 agonist or a sigma-1 positive modulator to the subject. In some cases the subject is administered fenfluramine as the sigma-1 positive modulator. In some cases, the subject has been diagnosed with epilepsy, traumatic brain injury, migraines, stroke, ischemic attacks, hypoxia or an increased risk of sudden unexpected death in epilepsy (SUDEP), or a combination thereof.

Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

Disclosed is a system for increasing attention ability of a user using a gameplay. The system may include a display device configured to display a moving image comprising an object, a cursor and a points counter. Further, the system may include an audio device configured to produce acoustic waves based on a sound data associated with a level. Further, the system may include an input device configured to receive a spatial input data. Further, the system may include a processing device communicatively coupled to each of the display device, the audio device and the input device. Further, the system may include a storage device communicatively coupled to the processing device. Further, the storage device may be configured to store digital data corresponding to an object, a cursor, a current cursor location, a previous cursor location, a geometric shape and the sound data in association with the multiple level indicators.

Disclosed is a system for increasing attention ability of a user using a gameplay. The system may include a display device configured to display a moving image comprising an object, a cursor and a points counter. Further, the system may include an audio device configured to produce acoustic waves based on a sound data associated with a level. Further, the system may include an input device configured to receive a spatial input data. Further, the system may include a processing device communicatively coupled to each of the display device, the audio device and the input device. Further, the system may include a storage device communicatively coupled to the processing device. Further, the storage device may be configured to store digital data corresponding to an object, a cursor, a current cursor location, a previous cursor location, a geometric shape and the sound data in association with the multiple level indicators.

An abnormality prediction device includes a detection unit that detects detection information including at least one of biological information of a user and body motion information regarding a body motion of the user, a premonitory symptom determination unit (control unit) that determines whether a premonitory symptom has occurred in the user on the basis of the detection information detected by the detection unit and a premonitory pattern which is a pattern of the detection information according to the premonitory symptom of abnormality occurring in the user, and an information output unit (control unit) that, when the premonitory symptom determination unit determines that the premonitory symptom has occurred, outputs notification information indicating that occurrence of abnormality in the user is predicted.

The present invention is for a method and system for pain classification and monitoring optionally in a subject that is an awake, semi-awake or sedated.

The present invention is for a method and system for pain classification and monitoring optionally in a subject that is an awake, semi-awake or sedated.

A method (100) is implemented by a computing device for helping a particular user use a user interface (UI). Electroencephalography (EEG) data is obtained (102) that indicates brain activity of a particular user during a period in which that user views the UI and/or interprets help information that describes how to use the UI. Based on the EEG data, the computing device selects (104), from among multiple pre-defined cognitive states, the one or more cognitive states that characterize the particular user during the period. The computing device assists (106) the particular user to use the UI by customizing the help information for the particular user based on the one or more selected cognitive states. A complementary computing device and computer program product are also disclosed.

A system for adjusting blood glucose level including an insulin delivery device configured to release insulin into the body of a person, and an EEG monitor having an EEG sensing part including EEG electrodes. The EEG monitor can be arranged in the ear region of the person with the EEG sensing part arranged subcutaneously at the scalp or arranged in the ear canal. The EEG monitor includes an EEG signal processor arranged at the ear and adapted for identifying onset of hypoglycemia. The system further includes a wireless link between the EEG monitor and the insulin delivery device. The EEG monitor is configured to submit a warning signal to the insulin delivery device if an upcoming onset of hypoglycemia is identified. The warning message will cause the insulin delivery device to restrict insulin delivery for a predetermined time, and a warning is provided to the person or to a caregiver.