A data processing method for detecting the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD), allowing objectively quantifying the effects that this has on the patient's electroencephalogram (EEG). The method of the invention provides an objective criterion for monitoring the brain health status of MCI subjects, which goes alongside the other criteria of neurological, psychological, clinical and cognitive assessment normally provided by the evaluation protocols of these patients.

A data processing method for detecting the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD), allowing objectively quantifying the effects that this has on the patient's electroencephalogram (EEG). The method of the invention provides an objective criterion for monitoring the brain health status of MCI subjects, which goes alongside the other criteria of neurological, psychological, clinical and cognitive assessment normally provided by the evaluation protocols of these patients.

A secondary battery built in a bio-signal measuring instrument (a wearable biosensor) is charged without using a dedicated charging terminal. A bio-signal measuring device includes: a battery as an internal power source and a charging circuit for the battery; electrodes which are brought into contact with the skin surface of the human body at the time of bio-signal measurement and are connected to a predetermined power feeder at the time of charging of the battery; a bio-signal processing circuit which processes bio-signals detected at the electrodes in a predetermined manner; and a bio-signal and feed power distribution device, in which the bio-signal processing circuit and the charging circuit are switchably connected to the electrodes through the bio-signal and feed power distribution device, and at the time of the charging of the battery, the electrodes are used as charging terminals.

A secondary battery built in a bio-signal measuring instrument (a wearable biosensor) is charged without using a dedicated charging terminal. A bio-signal measuring device includes: a battery as an internal power source and a charging circuit for the battery; electrodes which are brought into contact with the skin surface of the human body at the time of bio-signal measurement and are connected to a predetermined power feeder at the time of charging of the battery; a bio-signal processing circuit which processes bio-signals detected at the electrodes in a predetermined manner; and a bio-signal and feed power distribution device, in which the bio-signal processing circuit and the charging circuit are switchably connected to the electrodes through the bio-signal and feed power distribution device, and at the time of the charging of the battery, the electrodes are used as charging terminals.

The invention presented personalized biofeedback computerized system, an End-to-End eHealth smart platform for analysis, diagnosis and therapy of types of behavioral disorders. The system comprises a Captive Portal (CP) data input for initial input data and for continuous input data, a database comprising data, a Computer Processing Manager (CPM) for processing the patient data and the database, a Graphical User Interface (GUI) for interfacing with a user, and an Electroencephalography (EEG) or hemoencephalography (HEG) cap for stimulating predetermined areas in the brain, wherein the CPM is interconnected to the CPP, the database and the GUI, the CPM provides instructions for cranial electrode mediated stimulation to the areas in the brain according to a predetermined patient data dependent protocol, and the database provides external data. A preferred embodiment of the invention is a multilayered bio-feedbacking system.

A method for storing data of photoelectrically synchronous brain activity recording, said method comprising: generating data when a photoelectrically synchronous brain activity detection system is operating; generating from said data a data storage file comprising a basic information data segment, a near-infrared spectrum data segment and a brain electrical activity data segment, and sequentially storing said data segments into a .neg file in binary form according to the above order. The method can store comprehensive test information, flexibly configure the near-infrared and brain electrical measurement information, and realize synchronous storage of near-infrared data and brain electrical data and maintain file version compatibility.

Certain embodiments may relate to presenting advertisements in a virtualized environment. A method and apparatus may be provided. The method may include generating, by a virtual reality device, a virtualized environment for a user. The method may also include inserting an advertisement within the virtualized environment. The method may further include determining that the user has viewed the inserted advertisement. The method may also include determining a response of the user when the user views the inserted advertisement. The method may further include storing the response of the user.

The present specification describes methods and systems for modifying a media, such as Virtual Reality, Augmented Reality, or Mixed Reality (VR/AR/MxR) media based on a vision profile and a target application. In embodiments of the specification, a Sensory Data Exchange (SDE) is created that enables identification of various vision profiles for users and user groups. The SDE may be utilized to modify one or more media in accordance with each type of user and/or user group.

A physiological signal processing system/method for a physiological waveform that includes a cardiovascular signal component provides a first variable high pass filter that is responsive to the physiological waveform, and to a first corner frequency that is applied. A second variable high pass filter is responsive to a noise reference waveform from a noise reference sensor and is configured to high pass filter the noise reference waveform in response to a second corner frequency that is applied. A heart rate metric extractor is responsive to the variable high pass filters and is configured to extract a heart rate metric from the physiological waveform that is high pass filtered. A corner frequency adjuster is responsive to the heart rate metric extractor and is configured to determine the corner frequencies that are applied to the variable high pass filters, based on the heart rate metric that was extracted.

Maxillary devices and Mandibular devices each have a first housing connectable to a tooth of a user or connectable or integral with a teeth covering, wherein the housing encloses an on-board circuit board and a power source. The first housing of the maxillary devices has a tooth connecting portion, a palate housing portion and/or a buccal housing portion. The first housing of the mandibular devices has a tooth connecting portion and a sublingual portion. Each of the palate housing portion and the buccal housing portion enclose a stimulator having an electrode electrically connected to the on-board circuit board and the power source, and can enclose a sensor and/or a medicament dispenser. The sublingual portion encloses a sensor and a medicament dispenser each of which are in electrical communication with the microprocessor of the on-board circuit board.