The present disclosure facilitates capture (e.g., bipolar capture) of differentially-acquired wide-band phase gradient signals (e.g., wide-band cardiac phase gradient signals, wide-band cerebral phase gradient signals) that are simultaneously sampled. Notably, the exemplified system minimizes non-linear distortions (e.g., those that can be introduced via certain filters such as phase distortions) in the acquired wide-band phase gradient signals so as to not affect the information therein that can non-deterministically affect analysis of the wide-band phase gradient signal in the phase space domain. Further, a shield drive circuit and shield-drive voltage plane may be used to facilitate low noise and low interference operation of the acquisition system.

The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general anesthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.

The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general anesthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.

A system and method of treating a sleep disorder, including: detecting signals associated with at least one symptom or sign of the sleep disorder at one or more sensors; processing the signals to create a symbolic representation of the sleep disorder, wherein the symbolic representation indicates a relationship of the signals to the sleep disorder empirically and not based on physiologic mapping of the signals to the sleep disorder; and stimulating a region of a human body to alter the symbolic representation between detected signals and the sleep disorder, wherein the symbolic representation as altered indicates treatment of the sleep disorder.

A system and method of treating a sleep disorder, including: detecting signals associated with at least one symptom or sign of the sleep disorder at one or more sensors; processing the signals to create a symbolic representation of the sleep disorder, wherein the symbolic representation indicates a relationship of the signals to the sleep disorder empirically and not based on physiologic mapping of the signals to the sleep disorder; and stimulating a region of a human body to alter the symbolic representation between detected signals and the sleep disorder, wherein the symbolic representation as altered indicates treatment of the sleep disorder.

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.

In an aspect of the invention, a method of identifying sensory inputs affecting working memory load of an individual is provided. The method comprises monitoring (S101) working memory load of the individual using a sensor device, detecting (S102) an increase in the working memory load of the individual, and identifying (S103), in response to the detected increase, at least one sensory input affecting the working memory load of the individual.

The present disclosure pertains to systems and methods for encoding and/or decoding brain activity signals for data reduction. In a non-limiting embodiment, first user data associated with a first sleep session of a user is received. The first user data is determined to include at least a first instance of a first sleep feature being of a first data size. A first value representing the first instance during a first temporal interval is determined. First encoding data representing the first value is determine, the first encoding data being of a second data size that is less than the first data size. Second user data is generated by encoding the first user data using the first encoding data to represent the first instance in the second user data, and the second user data is stored.

The present disclosure pertains to systems and methods for encoding and/or decoding brain activity signals for data reduction. In a non-limiting embodiment, first user data associated with a first sleep session of a user is received. The first user data is determined to include at least a first instance of a first sleep feature being of a first data size. A first value representing the first instance during a first temporal interval is determined. First encoding data representing the first value is determine, the first encoding data being of a second data size that is less than the first data size. Second user data is generated by encoding the first user data using the first encoding data to represent the first instance in the second user data, and the second user data is stored.