A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

With respect to the methodology of using the Huygens sensing array, the invention includes an improvement in a method of sensing biopotentials in tissue including the steps of: providing a Huygens sensor array; and sensing a native electrical biopotential signal using at least one electrode on a catheter with an amplifier circuit placed on the inner surface of the at least one electrode in the Huygens sensor array to generate a well-formed waveform of the biopotential showing clear electrical properties indicative of the tissue with a SFDR of at least 24.9 dB and SNR of at least ?13 dB. In one embodiment the tissue is cardiac tissue and the biopotential signal sensed by the Huygens sensing array is a native cardiac waveform. In one embodiment the sensed biopotential signal is a manifestation of underlying electrochemical activity sensed by the Huygens sensing array of a biological substrate corresponding to the tissue.

With respect to the methodology of using the Huygens sensing array, the invention includes an improvement in a method of sensing biopotentials in tissue including the steps of: providing a Huygens sensor array; and sensing a native electrical biopotential signal using at least one electrode on a catheter with an amplifier circuit placed on the inner surface of the at least one electrode in the Huygens sensor array to generate a well-formed waveform of the biopotential showing clear electrical properties indicative of the tissue with a SFDR of at least 24.9 dB and SNR of at least ?13 dB. In one embodiment the tissue is cardiac tissue and the biopotential signal sensed by the Huygens sensing array is a native cardiac waveform. In one embodiment the sensed biopotential signal is a manifestation of underlying electrochemical activity sensed by the Huygens sensing array of a biological substrate corresponding to the tissue.

An apparatus for stimulating a part of a peripheral nervous system comprises: a sensor unit comprising at least one ultrasound transducer configured to transmit ultrasound into the part of the peripheral nervous system and at least one pair of electrodes configured to detect electrical signals in the part of the peripheral nervous system, wherein the sensor unit is configured to determine structural information and functional information of the part of the peripheral nervous system; a stimulation unit configured to transmit a stimulation signal for selective stimulation of a position within the part of the peripheral nervous system; and a controller configured to receive the structural information and the functional information and configured to control a location of the selective stimulation within the part of the peripheral nervous system based on the structural information and the functional information.

An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.

Systems, devices, methods, and techniques are described for using evoked compound action potential (ECAP) signals to determine an implant location for a lead. An example method includes receiving first information representative of a first evoked compound action potential (ECAP) signal sensed in response to a first control stimulus delivered to a first location adjacent to a spinal cord of a patient. The method also includes receiving, second information representative of a second ECAP signal in response to a second control stimulus delivered to a second location adjacent to the spinal cord of the patient. Additionally, the method includes outputting a first indication of the first information representative of the first ECAP signal and a second indication of the second information representative of the second ECAP signal.

This method for acquiring electrical signals from a plurality of lead wires uses an electrode structure to detect a plurality electrical signals from the plurality of lead wires, and includes: the feature wherein the electrode structure comprises a plurality of electrode layers arranged so as to be separated from each other, each of the plurality of electrode layers has a plurality of holes having dimensions such that the plurality of lead wires can pass therethrough, and each of the plurality of holes is connected to a conductor that conducts an electrical signal propagating through the lead wire passing through the hole to the outside of the electrode structure; and the feature of distinguishing between the detected plurality of electrical signals.

A sensing electrode selection algorithm is disclosed for use with an implantable pulse generator having an electrode array. The algorithm automatically selects optimal sensing electrodes in the array to be used with a pre-determined stimulation therapy appropriate for the patient. The algorithm preferably senses stimulation artifacts using different sensing electrodes, and more specifically different sensing electrode pairs as is appropriate when differential sensing is used. The algorithm further preferably senses these stimulation artifacts with the patient placed in two or more postures. The algorithm processes the stimulation artifact features measured at the different sensing electrodes and at the different postures to automatically determine one or more sensing electrode pairs that best distinguishes the two or more postures given the prescribed stimulation therapy.

A sensing electrode selection algorithm is disclosed for use with an implantable pulse generator having an electrode array. The algorithm automatically selects optimal sensing electrodes in the array to be used with a pre-determined stimulation therapy appropriate for the patient. The algorithm preferably senses stimulation artifacts using different sensing electrodes, and more specifically different sensing electrode pairs as is appropriate when differential sensing is used. The algorithm further preferably senses these stimulation artifacts with the patient placed in two or more postures. The algorithm processes the stimulation artifact features measured at the different sensing electrodes and at the different postures to automatically determine one or more sensing electrode pairs that best distinguishes the two or more postures given the prescribed stimulation therapy.

An implantable medical device (IMD) configured to sense biosignals of a patient. The IMD comprises one or more power components for powering the IPG and sensing circuitry for sensing one or more biosignals of the patient, wherein the sensing circuitry comprises a hybrid circuit having a BJT portion and a CMOS FET portion, the BJT portion configured to amplify low voltage signals with low equivalent noise and the CMOS FET portion forming a power-optimized output stage.