Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

A neuromodulation system and method. An implantable electrode array comprises a plurality of electrodes. A stimulus source provides neural stimuli delivered via stimulus electrodes to neural tissue to evoke neural responses. Measurement circuitry captures signal windows sensed from the neural tissue subsequent to each stimulus. A control unit controls the neural stimuli according to a stimulus intensity parameter. A processor introduces a perturbation to the parameter from a baseline stimulus intensity. A time series of intensities of the evoked neural responses is obtained. from which a time series of estimates of at least one physiological characteristic of the neural tissue is obtained. Each physiological characteristic being variable as a result of a posture wave. A baseline value of each physiological characteristic is estimated from the time series of estimates of each physiological characteristic.

An integrated multi-modality system has a first modality corresponding to an EDX or physiological device, including associated amplifier and different types of stimulators, and a second modality corresponding to an US device, including associated probes and beam former, in data communication with a computing device. The system is configured to synchronize EDX and US devices for time-locked collection and analysis of both the EDX and US data thereby allowing combined functionality, review, and analysis. The system generates an integrated multi-modal data file that combines the processed EDX and/or physiological and US data into a unitary file with a singular format thereby supporting a plurality of clinical applications.

An integrated multi-modality system has a first modality corresponding to an EDX or physiological device, including associated amplifier and different types of stimulators, and a second modality corresponding to an US device, including associated probes and beam former, in data communication with a computing device. The system is configured to synchronize EDX and US devices for time-locked collection and analysis of both the EDX and US data thereby allowing combined functionality, review, and analysis. The system generates an integrated multi-modal data file that combines the processed EDX and/or physiological and US data into a unitary file with a singular format thereby supporting a plurality of clinical applications.

A method for performing percutaneous spinal interbody fusion on a spine of a patient can include inserting without direct visualization a neuro-monitoring dilating probe into the patient, performing neuro-monitoring via the neuro-monitoring dilating probe, advancing the neuro-monitoring dilating probe into a disc space, passing a second dilator over the neuro-monitoring dilating probe, and advancing the second dilator into the disc space. A kit for performing percutaneous spinal interbody fusion can include a neuro-monitoring dilating probe, a second dilator, a tissue removal tool, an access portal comprising an adjustable depth stop, and a discectomy verification device.

The invention features a cuff device comprising a support having a first end, a second end and an elongated body in between; connection means for electrical, magnetic and/or fluidic magnetic connection with external devices; at least one of i) an electrode and/or electronic component operatively connected with said connection means configured to electrically interface with a biological tissue and ii) a channel having an inlet, an outlet and an elongated body in between operatively connected with said connection means via said inlet and configured to fluidically interface with a biological tissue via said outlet; and at least one buckle configured to receive said first end and permit the sliding therein of said elongated body so to close and lock the cuff electrode device at desired positions, characterized in that said support is stretchable.

The invention features a cuff device comprising a support having a first end, a second end and an elongated body in between; connection means for electrical, magnetic and/or fluidic magnetic connection with external devices; at least one of i) an electrode and/or electronic component operatively connected with said connection means configured to electrically interface with a biological tissue and ii) a channel having an inlet, an outlet and an elongated body in between operatively connected with said connection means via said inlet and configured to fluidically interface with a biological tissue via said outlet; and at least one buckle configured to receive said first end and permit the sliding therein of said elongated body so to close and lock the cuff electrode device at desired positions, characterized in that said support is stretchable.

In one example, the disclosure describes a method comprising receiving, by processing circuitry, information indicative of one or more evoked compound action potential (ECAP) signals. The one or more ECAP signals are sensed by at least one electrode carried by a medical lead. The processing circuitry determining that at least one characteristic value of the one or more ECAP signals is outside of an expected range. Responsive to determining that the at least one characteristic value of the one or more ECAP signals is outside of the expected range, the processing circuitry performs a lead integrity test for the medical lead.

In systems and methods for dynamically generating reference limits for use in a neuromonitoring system, a first set of neuromonitoring data from separate patient tests conducted by the neuromonitoring system is received. Each of the separate patient tests is associated with variables. Each of the variables is associated with a corresponding one of the first neuromonitoring data as metadata. The first set of neuromonitoring data is compiled with associated metadata into one or more reference limits. When neuromonitoring data is received from a second patient test, at least one analysis is applied to the second patient test using the one or more reference limits.

In systems and methods for dynamically generating reference limits for use in a neuromonitoring system, a first set of neuromonitoring data from separate patient tests conducted by the neuromonitoring system is received. Each of the separate patient tests is associated with variables. Each of the variables is associated with a corresponding one of the first neuromonitoring data as metadata. The first set of neuromonitoring data is compiled with associated metadata into one or more reference limits. When neuromonitoring data is received from a second patient test, at least one analysis is applied to the second patient test using the one or more reference limits.