Provided are devices and methods for preventing an episode of incontinence in an individual in need thereof. The devices comprise a sensor and a stimulator electrode that can be implanted into the body of the individual. Once the device is implanted in the individual, the sensor of the device senses a parameter that is associated with a response from the individual that is intended to prevent an episode of incontinence. Then, the device provides an electrical stimulation using the electrode that, together with the response, helps to prevent the episode of incontinence.

A method may include obtaining first and second time series (TS1), (TS2) of stimulation data, and a first and second time series of control data. TS1, TS2 may provide a plurality of pairs of data points such that each of the plurality of pairs include corresponding data points from both TS1 and TS2. The obtained time series may be analyzed by applying an algorithm (Alg) to TS1 and TS2 of stimulation data to create an algorithm value corresponding to each of the plurality of pairs of data points. Alg=(|TS1|+|TS2|)/2|TS1TS2|. Positive algorithm values for a predetermined period of time (AlgVarTime) may be summed to create a signal. Peak(s) in the signal may be determined, and a conduction velocity may be determined using a latency and a distance between a stimulus electrode and a recording electrode.

A method may include obtaining first and second time series (TS1), (TS2) of stimulation data, and a first and second time series of control data. TS1, TS2 may provide a plurality of pairs of data points such that each of the plurality of pairs include corresponding data points from both TS1 and TS2. The obtained time series may be analyzed by applying an algorithm (Alg) to TS1 and TS2 of stimulation data to create an algorithm value corresponding to each of the plurality of pairs of data points. Alg=(|TS1|+|TS2|)/2|TS1TS2|. Positive algorithm values for a predetermined period of time (AlgVarTime) may be summed to create a signal. Peak(s) in the signal may be determined, and a conduction velocity may be determined using a latency and a distance between a stimulus electrode and a recording electrode.

An electrode assembly (preferably in the form of a nerve cuff) comprises a base with first and second arms extending from opposite sides of the base, and which, in combination, define an arc. First and second electrically conductive electrodes extend along the inner surface of the first and second arms. Each electrode can comprise a single length of foil can or can comprise multiple discrete foil segments. The foils are electrically isolated from each other. Electrical wires, which are in electrical communication with the each of the foils, extend from the nerve cuff and are adapted to be electrically connected to a signal monitor. When the nerve cuff is applied to a nerve, the foils, in combination, substantially surround the nerve, with the first and second electrodes being on opposite sides of the nerve from each other. Also disclosed is a method of using the nerve cuff to monitor a nerve during a lumbar spinal surgery while the patient is anesthetized and paralyzed.

An electrode assembly (preferably in the form of a nerve cuff) comprises a base with first and second arms extending from opposite sides of the base, and which, in combination, define an arc. First and second electrically conductive electrodes extend along the inner surface of the first and second arms. Each electrode can comprise a single length of foil can or can comprise multiple discrete foil segments. The foils are electrically isolated from each other. Electrical wires, which are in electrical communication with the each of the foils, extend from the nerve cuff and are adapted to be electrically connected to a signal monitor. When the nerve cuff is applied to a nerve, the foils, in combination, substantially surround the nerve, with the first and second electrodes being on opposite sides of the nerve from each other. Also disclosed is a method of using the nerve cuff to monitor a nerve during a lumbar spinal surgery while the patient is anesthetized and paralyzed.

Methods of treating a genetic disorder and assessing AAV-induced dorsal root ganglia (DRG) toxicity in a subject are provided.

Methods of treating a genetic disorder and assessing AAV-induced dorsal root ganglia (DRG) toxicity in a subject are provided.

An implantable medical system includes a medical device connected to a medical lead with several neural interfaces. The system can selectively generate stimulation signals at a selected one of the several neural interfaces, such as nerve cuffs. Each neural interface has at least one working electrode that is common to all the neural interfaces. Each neural interface has at least one reference electrode that is dedicated to that interface. A neural interface that has not been selected to stimulate tissue has its dedicated reference electrode floating with respect to power and ground.

Presented herein are techniques for the determination and use of neural health maps. As used herein, a neural health map refers to a mapping that indicates the neural health of neurons within different regions of a complement of neurons. The neural health indicated in/by the neural health map indicates the ability of a neuron to respond to stimulation. Accordingly, a neural health map can indicate if a particular region of a complement of neurons provides normal response to stimulation, decreased response to stimulation, no response to stimulation (i.e., neuron death), etc.

Described herein are catheters for use in analyzing neural activity of nerves that surround a biological lumen. Such a catheter comprises a handle including a first, second, and third actuators, and a shaft extending from the handle and including proximal and distal electrodes that are selectively deployable. The first actuator is configured to selectively deploy the proximal electrode in response to the first actuator being manually maneuvered. The second actuator is configured to selectively deploy the distal electrode in response to the second actuator being manually maneuvered. The third actuator is configured to selectively adjust a longitudinal distance between the proximal and distal electrodes in response to the third actuator being manually maneuvered.