The present invention relates to an immunoglobulin therapy. In particular, an immunoglobulin therapy for treating CIDP with non-axonal damage or mild axonal damage is provided.

A system and method for modeling patient-specific spinal cord stimulation (SCS) is disclosed. The system and method acquire impedance and evoked compound action potential (ECAP) signals from a lead positioned proximate to a spinal cord (SC). The lead includes at least one electrode. The system and method determine a patient-specific anatomical model based on the impedance and ECAP signals, and transform a dorsal column (DC) map template based on a DC boundary of the patient-specific anatomical model. Further, the system and method map the transformed DC map template to the patient-specific anatomical model. The system and method may also include the algorithms to solve extracellular and intracellular domain electrical fields and propagation along neurons. The system and method may also include the user interfaces to collect patient responses and compare with the patient-specific anatomical model as well as using the patient-specific anatomical model for guiding SCS programming.

A system and method for modeling patient-specific spinal cord stimulation (SCS) is disclosed. The system and method acquire impedance and evoked compound action potential (ECAP) signals from a lead positioned proximate to a spinal cord (SC). The lead includes at least one electrode. The system and method determine a patient-specific anatomical model based on the impedance and ECAP signals, and transform a dorsal column (DC) map template based on a DC boundary of the patient-specific anatomical model. Further, the system and method map the transformed DC map template to the patient-specific anatomical model. The system and method may also include the algorithms to solve extracellular and intracellular domain electrical fields and propagation along neurons. The system and method may also include the user interfaces to collect patient responses and compare with the patient-specific anatomical model as well as using the patient-specific anatomical model for guiding SCS programming.

An interventional device (110) for detecting nerve activity, is provided. The interventional device includes: a magnetic sensor (120) that is coupled to an insertable portion of the interventional device. The magnetic sensor (120) is configured to generate signals in response to magnetic fields produced by nerve activity. A system (200) is also provided. The system includes the interventional device (110) and a controller (140) that is configured to receive the signals generated by the magnetic sensor (120), and to output a detection result indicative of nerve activity in response to the received signals.

The invention relates to an electrical nerve stimulation system for stimulating one or more nerves of a mammal with an electrical signal, said system comprising: a signal generation unit arranged for generating electrical stimulation pulses wherein an intensity of said pulses is configured for stimulating said one or more nerves of said mammal: a pair of electrodes connected to said signal generation unit and arranged for placement of said electrodes on the outer skin of said mammal: a control unit arranged for control of said signal generation unit: a power supply unit for powering said signal generation unit and said control unit: wherein said signal generation unit comprises an inductor for inducing said stimulation pulses applied in a symmetric inversed manner to said pair of electrodes, and wherein the duration and/or timing of said stimulation pulses are varied over time.

Disclosed is a method and system for selecting a reference electrode wherein at least one electrode of an electrode assembly is configured in a sensing mode and is connected to a sensing circuitry configured to measure a neural potential. Further, the electrodes configured in the sensing mode includes at least one measuring electrode and at least one reference electrode. The method and system can configure the electrodes of the electrode assembly based on conditions related to the stimulation and neural measurement.

Disclosed is a method and system for selecting a reference electrode wherein at least one electrode of an electrode assembly is configured in a sensing mode and is connected to a sensing circuitry configured to measure a neural potential. Further, the electrodes configured in the sensing mode includes at least one measuring electrode and at least one reference electrode. The method and system can configure the electrodes of the electrode assembly based on conditions related to the stimulation and neural measurement.

Disclosed herein are of systems, methods, and computer-program products of determining a peripheral neural synchrony value based on eCAPS and correlating the peripheral neural synchrony value with temporal resolution acuity and speech perception outcomes measured in quiet and in noise in the patient.

Disclosed herein are of systems, methods, and computer-program products of determining a peripheral neural synchrony value based on eCAPS and correlating the peripheral neural synchrony value with temporal resolution acuity and speech perception outcomes measured in quiet and in noise in the patient.

Systems and methods for enhancing diagnostic evoked potential recordings of a nerve or nerve pathway of interest. A grid array of stimulating electrodes are placed on, over, or through skin in a location beneath which a nerve or nerve pathway is suspected to lie. A stimulator controls the grid array, where each electrode is independently controllable as active or inactive, as a cathode or anode, etc. A plurality of recording electrodes may record Somato-Sensory Evoked Potentials (SSEPs) and/or Transcranial Electrical Motor Evoked Potentials (TCeMEP) in response to activation of the stimulating electrodes. A processor controls stimulating the stimulating electrodes, and receives responses from the recording electrodes, in a general search mode and a focused search mode in order to use a minimum stimulation intensity at which a maximum response amplitude is detected to continually stimulate the nerve or the nerve pathway.