A method includes, for each corresponding electrode of one or more electrodes attached to a head of a patient, receiving corresponding electrical activity data representing neural activity within a corresponding area of a brain of the patient based on corresponding electrical activity measured by the corresponding electrode. The method also includes receiving stimulation data representing a plurality of stimulation times each corresponding to a stimulation applied to the patient while the one or more electrodes are attached to the head of the patient, and processing the corresponding electrical activity data and the stimulation data to determine a modulation depth for the patient. The method also includes assessing, based on the modulation depth, cognitive impairment of the patient due to a diagnosis of schizophrenia.

Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient and/or guide an implant procedure.

Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient and/or guide an implant procedure.

A sensing electrode selection algorithm is disclosed for use with an implantable pulse generator having an electrode array. The algorithm automatically selects optimal sensing electrodes in the array to be used with a pre-determined stimulation therapy appropriate for the patient. The algorithm preferably senses stimulation artifacts using different sensing electrodes, and more specifically different sensing electrode pairs as is appropriate when differential sensing is used. The algorithm further preferably senses these stimulation artifacts with the patient placed in two or more postures. The algorithm processes the stimulation artifact features measured at the different sensing electrodes and at the different postures to automatically determine one or more sensing electrode pairs that best distinguishes the two or more postures given the prescribed stimulation therapy.

A sensing electrode selection algorithm is disclosed for use with an implantable pulse generator having an electrode array. The algorithm automatically selects optimal sensing electrodes in the array to be used with a pre-determined stimulation therapy appropriate for the patient. The algorithm preferably senses stimulation artifacts using different sensing electrodes, and more specifically different sensing electrode pairs as is appropriate when differential sensing is used. The algorithm further preferably senses these stimulation artifacts with the patient placed in two or more postures. The algorithm processes the stimulation artifact features measured at the different sensing electrodes and at the different postures to automatically determine one or more sensing electrode pairs that best distinguishes the two or more postures given the prescribed stimulation therapy.

Methods and systems for recording evoked potentials evoked during electrical stimulation of a patient's neural tissue are disclosed. The methods and systems are useful with treatment modalities, such as spinal cord stimulation (SCS). The disclosed methods and system allow for stimulation artifacts to be reduced in, or removed from, the recorded signals. A residual portion of the stimulation artifact can be modeled and subtracted from a recorded signal that includes both artifact and neural response contributions.

Methods and systems for recording evoked potentials evoked during electrical stimulation of a patient's neural tissue are disclosed. The methods and systems are useful with treatment modalities, such as spinal cord stimulation (SCS). The disclosed methods and system allow for stimulation artifacts to be reduced in, or removed from, the recorded signals. A residual portion of the stimulation artifact can be modeled and subtracted from a recorded signal that includes both artifact and neural response contributions.

Devices, systems, and techniques are configured for independently modulating two or more concurrent signals of electrical stimulation therapy. In one example, a system includes stimulation generation circuitry and processing circuitry configured to control the stimulation generation circuitry to deliver first electrical stimulation to a patient via a first electrode combination, wherein the first electrical stimulation is defined by at least a first set of stimulation parameters selected that the first electrical stimulation exceeds a first perception threshold, and control the stimulation generation circuitry to deliver second electrical stimulation, concurrent with the first electrical stimulation, to the patient via a second electrode combination. The second electrical stimulation may be defined by at least a second set of stimulation parameters selected that the second electrical stimulation is below a second perception threshold. The processing circuitry may also determine a triggering condition and independently modulate the first and/or second electrical stimulation.

Devices, systems, and techniques are configured for independently modulating two or more concurrent signals of electrical stimulation therapy. In one example, a system includes stimulation generation circuitry and processing circuitry configured to control the stimulation generation circuitry to deliver first electrical stimulation to a patient via a first electrode combination, wherein the first electrical stimulation is defined by at least a first set of stimulation parameters selected that the first electrical stimulation exceeds a first perception threshold, and control the stimulation generation circuitry to deliver second electrical stimulation, concurrent with the first electrical stimulation, to the patient via a second electrode combination. The second electrical stimulation may be defined by at least a second set of stimulation parameters selected that the second electrical stimulation is below a second perception threshold. The processing circuitry may also determine a triggering condition and independently modulate the first and/or second electrical stimulation.

A system for modulating bladder function is disclosed. A system for evaluating the electrophysiological function of a bladder is disclosed. Methods for performing a controlled surgical procedure on a bladder are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and/or performing a neuromodulation procedure on a bladder is disclosed.