The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameterps (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).

The present invention relates to a system and methods generally aimed at surgery. More particularly, the present invention is directed at a system and related methods for performing surgical procedures and assessments involving the use of neurophysiology.

Separating a compound action potential from an artefact in a neural recording. A memory stores a set of basis functions comprising at least one compound action potential basis function and at least one artefact basis function. A neural recording of electrical activity in neural tissue is decomposed by determining at least one of a compound action potential and an artefact from the set of basis functions. An estimate is output of at least one of a compound action potential and an artefact.

Separating a compound action potential from an artefact in a neural recording. A memory stores a set of basis functions comprising at least one compound action potential basis function and at least one artefact basis function. A neural recording of electrical activity in neural tissue is decomposed by determining at least one of a compound action potential and an artefact from the set of basis functions. An estimate is output of at least one of a compound action potential and an artefact.

Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

A method may include obtaining first and second time series (TS1), (TS2) of stimulation data, and a first and second time series of control data. TS1, TS2 may provide a plurality of pairs of data points such that each of the plurality of pairs include corresponding data points from both TS1 and TS2. The obtained time series may be analyzed by applying an algorithm (Alg) to TS1 and TS2 of stimulation data to create an algorithm value corresponding to each of the plurality of pairs of data points. Alg=(|TS1|+|TS2|)/2−|TS1−TS2|. Positive algorithm values for a predetermined period of time (AlgVarTime) may be summed to create a signal. Peak(s) in the signal may be determined, and a conduction velocity may be determined using a latency and a distance between a stimulus electrode and a recording electrode.

A method may include obtaining first and second time series (TS1), (TS2) of stimulation data, and a first and second time series of control data. TS1, TS2 may provide a plurality of pairs of data points such that each of the plurality of pairs include corresponding data points from both TS1 and TS2. The obtained time series may be analyzed by applying an algorithm (Alg) to TS1 and TS2 of stimulation data to create an algorithm value corresponding to each of the plurality of pairs of data points. Alg=(|TS1|+|TS2|)/2−|TS1−TS2|. Positive algorithm values for a predetermined period of time (AlgVarTime) may be summed to create a signal. Peak(s) in the signal may be determined, and a conduction velocity may be determined using a latency and a distance between a stimulus electrode and a recording electrode.

Disclosed herein are a neural signal feedback system and method. The neural signal feedback system includes: a microelectrode array unit configured such that a plurality of microelectrodes is disposed on a substrate and such that one microelectrode, which is a reference electrode, and corresponding electrode groups including other microelectrodes located at different same distances from the reference electrode are set; and an analysis and determination unit configured to compare neural signal values, measured in the microelectrode array unit, with a preset reference value, and to determine whether to apply the electrical stimulation of the microelectrode array unit. The analysis and determination unit performs re-measurement after the application of electrical stimulation, and repeats the application of electrical stimulation and measurement until the measured values reach the reference value.

Disclosed herein are a neural signal feedback system and method. The neural signal feedback system includes: a microelectrode array unit configured such that a plurality of microelectrodes is disposed on a substrate and such that one microelectrode, which is a reference electrode, and corresponding electrode groups including other microelectrodes located at different same distances from the reference electrode are set; and an analysis and determination unit configured to compare neural signal values, measured in the microelectrode array unit, with a preset reference value, and to determine whether to apply the electrical stimulation of the microelectrode array unit. The analysis and determination unit performs re-measurement after the application of electrical stimulation, and repeats the application of electrical stimulation and measurement until the measured values reach the reference value.

In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.