Devices and methods for stimulation and recording of muscle responses for determining degree of neuromuscular blockade, particularly relevant to elicitation of such responses in those under the influence of anesthesia. A system for estimating the degree of neuromuscular blockade includes at least one stimulating electrode, at least one recording electrode, a pulse generator for providing stimulation to a nerve through the stimulating electrode, and a computing device configured to: apply stimuli to the nerve according to a stimulation protocol, wherein the stimulation protocol provides a plurality of stimulation sequences that vary in frequency of pulses in the stimulation sequence, frequency of the stimulation sequences, number of pulses in the stimulation sequence, or all of the above; measure, by the recording electrode, electrical responses of a muscle; and estimate the degree of neuromuscular blockade based on changes in the electrical responses of the muscle during a stimulation sequence.

Devices and methods for stimulation and recording of muscle responses for determining degree of neuromuscular blockade, particularly relevant to elicitation of such responses in those under the influence of anesthesia. A system for estimating the degree of neuromuscular blockade includes at least one stimulating electrode, at least one recording electrode, a pulse generator for providing stimulation to a nerve through the stimulating electrode, and a computing device configured to: apply stimuli to the nerve according to a stimulation protocol, wherein the stimulation protocol provides a plurality of stimulation sequences that vary in frequency of pulses in the stimulation sequence, frequency of the stimulation sequences, number of pulses in the stimulation sequence, or all of the above; measure, by the recording electrode, electrical responses of a muscle; and estimate the degree of neuromuscular blockade based on changes in the electrical responses of the muscle during a stimulation sequence.

The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject's cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback.

Artifacts due to delivery of an electrical signal (e.g., for neural stimulation or nerve block) can be eliminated from neural recordings. An activating stimulus (AS) can be applied by at least one neural electrode located at a first position within a body or a preparation proximal to a neural structure. The AS includes an electrical waveform configured to affect (e.g., stimulate or block) conduction in the neural structure. A counter stimulus (CS) can be applied by at least one electrode located at a second position within the body or the preparation remote from the neural structure. The CS includes an electrical waveform configured with a timing parameter and an amplitude parameter selected based on a feature of the AS. Artifacts due to the AS can be blocked by the CS during the neural recordings.

Artifacts due to delivery of an electrical signal (e.g., for neural stimulation or nerve block) can be eliminated from neural recordings. An activating stimulus (AS) can be applied by at least one neural electrode located at a first position within a body or a preparation proximal to a neural structure. The AS includes an electrical waveform configured to affect (e.g., stimulate or block) conduction in the neural structure. A counter stimulus (CS) can be applied by at least one electrode located at a second position within the body or the preparation remote from the neural structure. The CS includes an electrical waveform configured with a timing parameter and an amplitude parameter selected based on a feature of the AS. Artifacts due to the AS can be blocked by the CS during the neural recordings.

A bruxism training device is disclosed that is capable of detecting bruxism events (e.g., jaw clenching and teeth grinding) via external electromyography (EMG). The training device is shaped to be easily placed in a proper location and proper orientation over a masseter muscle of a user. A locator region is provided to facilitate easy locating of a reference electrode over the gonial angle of the mandible, while an alignment edge of the training device is provided to facilitate easy locating of end electrodes adjacent an end of the masseter muscle coupled to the mandible. With the locator region and alignment edge in place, an array of mid electrodes is automatically positioned over a bulk of the masseter muscle, allowing useful EMG measurement to be acquired of masseter activation.

A bruxism training device is disclosed that is capable of detecting bruxism events (e.g., jaw clenching and teeth grinding) via external electromyography (EMG). The training device is shaped to be easily placed in a proper location and proper orientation over a masseter muscle of a user. A locator region is provided to facilitate easy locating of a reference electrode over the gonial angle of the mandible, while an alignment edge of the training device is provided to facilitate easy locating of end electrodes adjacent an end of the masseter muscle coupled to the mandible. With the locator region and alignment edge in place, an array of mid electrodes is automatically positioned over a bulk of the masseter muscle, allowing useful EMG measurement to be acquired of masseter activation.

Disclosed herein is a system, including a mobile device; a sensor module attached to the mobile device, the sensor module including a temperature sensor, an infrared sensor, at least one conductance sensor, and at least one electromyography sensor; and an application installed on the mobile device, wherein during operation the application causes the mobile device to receive data from one or more of the temperature sensor, the infrared sensor, the at least one conductance sensor, and the at least one electromyography sensor, and to determine information about a stress level of a human subject based on the received data.

Disclosed herein is a system, including a mobile device; a sensor module attached to the mobile device, the sensor module including a temperature sensor, an infrared sensor, at least one conductance sensor, and at least one electromyography sensor; and an application installed on the mobile device, wherein during operation the application causes the mobile device to receive data from one or more of the temperature sensor, the infrared sensor, the at least one conductance sensor, and the at least one electromyography sensor, and to determine information about a stress level of a human subject based on the received data.

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.