The present invention provides a method of conducting a sleep analysis by collecting physiologic and kinetic data from a subject, preferably via a wireless in-home data acquisition system, while the subject attempts to sleep at home. The sleep analysis, including clinical and research sleep studies and cardiorespiratory studies, can be used in the diagnosis of sleeping disorders and other diseases or conditions with sleep signatures, such as Parkinson's, epilepsy, chronic heart failure, chronic obstructive pulmonary disorder, or other neurological, cardiac, pulmonary, or muscular disorders. The method of the present invention can also be used to determine if environmental factors at the subject's home are preventing restorative sleep.

The present invention provides a method of conducting a sleep analysis by collecting physiologic and kinetic data from a subject, preferably via a wireless in-home data acquisition system, while the subject attempts to sleep at home. The sleep analysis, including clinical and research sleep studies and cardiorespiratory studies, can be used in the diagnosis of sleeping disorders and other diseases or conditions with sleep signatures, such as Parkinson's, epilepsy, chronic heart failure, chronic obstructive pulmonary disorder, or other neurological, cardiac, pulmonary, or muscular disorders. The method of the present invention can also be used to determine if environmental factors at the subject's home are preventing restorative sleep.

An illustrative system includes a stimulation device configured to apply stimulation to a recipient, a sensing device configured to detect a physiological condition of the recipient, and a processing unit communicatively coupled to the stimulation device and the sensing device. The processing unit determines a stimulation strategy that is customized to the recipient and includes stimulation frames and stimulation gaps. The processing unit then directs the stimulation device to apply the stimulation to the recipient in accordance with the stimulation strategy by applying the stimulation only during time that corresponds to the stimulation frames. The processing unit also directs the sensing device to detect the physiological condition of the recipient in accordance with the stimulation strategy by detecting only during time that corresponds to the stimulation gaps. Based on the detected physiological condition, the processing unit performs an action. Corresponding systems, methods, and apparatuses are also disclosed.

An illustrative system includes a stimulation device configured to apply stimulation to a recipient, a sensing device configured to detect a physiological condition of the recipient, and a processing unit communicatively coupled to the stimulation device and the sensing device. The processing unit determines a stimulation strategy that is customized to the recipient and includes stimulation frames and stimulation gaps. The processing unit then directs the stimulation device to apply the stimulation to the recipient in accordance with the stimulation strategy by applying the stimulation only during time that corresponds to the stimulation frames. The processing unit also directs the sensing device to detect the physiological condition of the recipient in accordance with the stimulation strategy by detecting only during time that corresponds to the stimulation gaps. Based on the detected physiological condition, the processing unit performs an action. Corresponding systems, methods, and apparatuses are also disclosed.

An implant unit configured for implantation into a body of a subject is provided. The implant unit may include a flexible carrier unit including a central portion and two elongated arms extending from the central portion, an antenna, located on the central portion, configured to receive a signal, at least one pair of electrodes arranged on a first elongated arm of the two elongated arms. The at least one pair of electrodes may be adapted to modulate a first nerve. The elongated arms of the flexible carrier may be configured to form an open ended curvature around a muscle with the nerve to be stimulated within an arc of the curvature.

Closed loop control of electrical stimulation therapy by measuring a neuromuscular response to determine that the electrical stimulation therapy is adequately stimulating the target nerve. In some examples, a system using the techniques of this disclosure may measure a reflex response, e.g., using electromyography (EMG), which measures muscle response or electrical activity in response to a nerve’s stimulation of the muscle. In some examples, the techniques of this disclosure may measure an H-reflex, such as an evoked motor response that occurs caused by a first afferent stimulation, through a signal synapse, and an efferent alpha-motor neuron excitation.

A method of determining a measure of contact of an EMG sensor with the skin of a human or animal subject, the method comprising: receiving data captured by the EMG sensor; calculating a spectral entropy of the received data over a first time period in respect of a predetermined frequency band; determining a measure of contact for the first time period in dependence on the spectral entropy of the received data; and processing the received data of the first time period in dependence on the measure of contact.

Provided are systems and methods for tracking one or more electrode positions.

One aspect of the present disclosure can include an intrafascicular neural electrode. The intrafascicular neural electrode can include a microwire body having a proximal end, a distal anchoring end, and a middle portion extending between the proximal end and the distal anchoring end. The distal anchoring end can substantially match the mechanical and biological properties of the target nerve. The microwire body can have a middle anchoring portion extending between the proximal end and the distal end, wherein at least a portion of the distal end and/or the middle anchoring portion substantially match(es) the mechanical and biological properties of the target nerve. The electrode can be made of graphene. The microwire body, except for the distal anchoring end, can be coated with an insulation material, preferably with a biocompatible agent adsorbed onto the insulation material.

One aspect of the present disclosure can include an intrafascicular neural electrode. The intrafascicular neural electrode can include a microwire body having a proximal end, a distal anchoring end, and a middle portion extending between the proximal end and the distal anchoring end. The distal anchoring end can substantially match the mechanical and biological properties of the target nerve. The microwire body can have a middle anchoring portion extending between the proximal end and the distal end, wherein at least a portion of the distal end and/or the middle anchoring portion substantially match(es) the mechanical and biological properties of the target nerve. The electrode can be made of graphene. The microwire body, except for the distal anchoring end, can be coated with an insulation material, preferably with a biocompatible agent adsorbed onto the insulation material.