A device for obtaining retinal ERG signals from a target area of the retina, the device comprising means for obtaining an electrical response signal from the target area and at least one light source configured to provide at least a stimulus beam configured to illuminate the target area for inducing an ERG signal and a light adapting background beam configured to illuminate the retina at least in an area outside of the target area, for light adapting the area outside of the target area and suppressing ERG signaling therefrom.

The present disclosure generally relates to devices, systems, and methods for detecting, monitoring, predicting, and/or treating medical conditions (e.g., epileptic seizures) using one or more sensors configured to collect biomarker data from a human subject (e.g., vagal tone and/or physiological or other biomarkers).

A wearable device, a signal processing method and a signal processing device are disclosed. The wearable device includes a processor and a signal collector electrically connected to the processor. The signal collector includes at least one electroencephalogram sensor configured to collect an electroencephalogram signal and at least one electrooculogram sensor configured to collect an electrooculogram signal. The processor is configured to generate a control signal based on the electroencephalogram signal and the electrooculogram signal, and the electroencephalogram sensor and the electrooculogram sensor are different sensors.

This invention is a device which creates adjustable acoustic and/or thermal zones in a bed to address sleep issues such as bed partner snoring and hot flashes. Adjustable acoustic bed zones can be created with a flexible movable partition which longitudinally spans a bed from an arch at the head of the bed to an arch at the foot of the bed. Adjustable thermal bed zones can be created with inflow and outflow flexible longitudinal air tubes which are inserted into a space between layers of bedding.

A method for removing artifacts from an electroretinogram, the method comprising: visually stimulating at least one eye of a test subject, and using at least two electrodes to measure electrical responses from the at least one eye of the test subject; recording the electrical responses during, and for a predetermined period of time after, the time at which a visual stimulation is applied, whereby to generate a data set, wherein each electrical response is represented as a sweep comprising a plurality of voltage amplitude values and a plurality of corresponding time values; applying an elevated high pass filter to each sweep, wherein the elevated high pass filter is configured to remove any signal components with a frequency value of <1 hz; and plotting the resulting data set as an electroretinogram, in which the plurality of voltage amplitude values of the remaining signal is plotted on a first axis of an electroretinogram, and the plurality of corresponding time values of the remaining signal is plotted on a second axis of the electroretinogram.

A method for removing artifacts from an electroretinogram, the method comprising: visually stimulating at least one eye of a test subject, and using at least two electrodes to measure electrical responses from the at least one eye of the test subject; recording the electrical responses during, and for a predetermined period of time after, the time at which a visual stimulation is applied, whereby to generate a data set, wherein each electrical response is represented as a sweep comprising a plurality of voltage amplitude values and a plurality of corresponding time values; applying an elevated high pass filter to each sweep, wherein the elevated high pass filter is configured to remove any signal components with a frequency value of <1 hz; and plotting the resulting data set as an electroretinogram, in which the plurality of voltage amplitude values of the remaining signal is plotted on a first axis of an electroretinogram, and the plurality of corresponding time values of the remaining signal is plotted on a second axis of the electroretinogram.

A method is presented for forming a nanowire electrode. The method includes forming a plurality of nanowires over a first substrate, depositing a conducting layer over the plurality of nanowires, forming solder bumps and electrical interconnections over a second flexible substrate, and integrating nanowire electrode arrays to the second flexible substrate. The plurality of nanowires are silicon (Si) nanowires, the Si nanowires used as probes to penetrate skin of a subject to achieve electrical biopotential signals. The plurality of nanowires are formed over the first substrate by metal-assisted chemical etching.

A method is presented for forming a nanowire electrode. The method includes forming a plurality of nanowires over a first substrate, depositing a conducting layer over the plurality of nanowires, forming solder bumps and electrical interconnections over a second flexible substrate, and integrating nanowire electrode arrays to the second flexible substrate. The plurality of nanowires are silicon (Si) nanowires, the Si nanowires used as probes to penetrate skin of a subject to achieve electrical biopotential signals. The plurality of nanowires are formed over the first substrate by metal-assisted chemical etching.

The present disclosure provides electroretinography devices configured to detect biopotential signals from an eye of a subject. In some embodiments, the device is configured to prevent the subject's eyelids from closing over the device when placed in contact with the anterior surface of the subject's eye. In some embodiments, the device has a Young's modulus of no more than about 50 MPa. In some embodiments, the device includes a diffusing or refracting element configured to scatter, focus or diverge incident light. In other embodiments, the device includes a void through which incident light can enter the subject's eye without passing through any portion of the device.

The present disclosure provides electroretinography devices configured to detect biopotential signals from an eye of a subject. In some embodiments, the device is configured to prevent the subject's eyelids from closing over the device when placed in contact with the anterior surface of the subject's eye. In some embodiments, the device has a Young's modulus of no more than about 50 MPa. In some embodiments, the device includes a diffusing or refracting element configured to scatter, focus or diverge incident light. In other embodiments, the device includes a void through which incident light can enter the subject's eye without passing through any portion of the device.