A method removing artifacts from neural signals comprises receiving electroencephalography (EEG) data from an EEG system and providing the EEG data to a unified artifact removal framework for cleaning artifacts. The EEG data is provided to a first cleaning framework utilizing the first reference to clean first artifacts from the EEG data, and the outputting the EEG data from the first cleaning framework to a second cleaning framework. The second cleaning framework may operate in a similar manner utilizing second reference to clean second artifacts from the EEG data. This general process may be repeated as desired to clean various artifacts from EEG data, when a suitable reference for the artifacts to be removed is utilized. The frameworks utilize H∞ method or filtering involving a H∞ adapting rule to properly weigh the reference, and combining the subsequent output with incoming EEG data results in the desired removal of artifacts.

Injection of silicon oil (SO) to the anterior chamber of an eye efficiently induces intraocular pressure (IOP) elevation. This effect occurs without causing overt ocular structural damage or inflammatory responses while simulating acute glaucomatous changes that human patients develop over years by inducing progressive RGC and ON degeneration and visual functional deficits within weeks. The anterior segments of the experimental eyes are not substantially affected, leaving clear ocular elements that allow easy and reliable assessment of in vivo visual function and morphology. More importantly, this is the only reversible ocular hypertension model by removing SO from the anterior chamber and particularly useful for testing neuro-protection treatment together with lowering IOP treatment. In summary, the acute ocular hypertension glaucoma model replicates secondary post-operative glaucoma. It is straightforward and reversible, does not require special equipment or repeat injections, and may be applicable to a range of animal species with only minor modifications.

A coupling arrangement for a bio-signal measurement, comprises at least two spring connectors of a bio-signal processing device, and a holder comprising a combination of a wall and a substrate, which form a pocket inside the holder, the wall following an outer contour of the bio-signal processing device. The holder has an aperture for inserting the bio-signal processing device into the pocket and removing the bio-signal processing device from the pocket. The holder includes electric conductor lines, which are in a wired electric contact with electrodes of the substrate, the electrodes receiving at least one bio-signal. The electric conductor lines are attached on the substrate inside the pocket, the electric conductor lines and the at least two spring connectors connecting electrically with each other in response to insertion of the bio-signal processing device in the pocket.

A sensing system comprising a hand-held sensing device with a vibracoustic sensor module (VSM). The VSM comprises a voice coil component comprising a coil holder supporting wire windings; a magnet component comprising a magnet supported by a frame, a magnet gap configured to receive at least a portion of the voice coil component in a spaced and moveable manner; a connector connecting the voice coil component to the magnet component, the connector being compliant and permitting relative movement of the voice coil component and the magnet component; a diaphragm configured to induce a movement of the voice coil component in the magnet gap responsive to incident acoustic waves; a housing for retaining the vibroacoustic sensor module having a handle end and a sensor end, the sensor end having an opening, the VSM positioned such that at least a portion of the diaphragm extends across the opening.

A method for picking up body signals from the head of a user comprises a) placing first and second electrodes on first and second different positions at a first side of the user's head in direct or capacitive contact with the user's head, said first side comprising a first eye of the user, the first and second electrodes being configured to pick up first and second electric potentials, respectively, from the user's body, and b) providing an Electrooculography signal representative of a corneo-retinal potential difference of said first eye of the user in dependence of said at first and second electric potentials. The first and second positions may be (substantially) located in a plane including the first eye of the user. A portable electronic device providing an Electrooculography signal, and a hearing device utilizing an Electrooculography signal is further disclosed.

A method for picking up body signals from the head of a user comprises a) placing first and second electrodes on first and second different positions at a first side of the user's head in direct or capacitive contact with the user's head, said first side comprising a first eye of the user, the first and second electrodes being configured to pick up first and second electric potentials, respectively, from the user's body, and b) providing an Electrooculography signal representative of a corneo-retinal potential difference of said first eye of the user in dependence of said at first and second electric potentials. The first and second positions may be (substantially) located in a plane including the first eye of the user. A portable electronic device providing an Electrooculography signal, and a hearing device utilizing an Electrooculography signal is further disclosed.

A system for testing different regions of the retina of a subject for retinal function, said system comprising: a monitor configured to display a visual electrophysiology stimulus to the subject, wherein the visual electrophysiology stimulus comprises a four ring visual electrophysiology stimulus; at least one active electrode; at least one reference electrode; and a computer configured to receive electrical signals from said at least one active electrode and said at least one reference electrode, and process the electrical signals.

A system for testing different regions of the retina of a subject for retinal function, said system comprising: a monitor configured to display a visual electrophysiology stimulus to the subject, wherein the visual electrophysiology stimulus comprises a four ring visual electrophysiology stimulus; at least one active electrode; at least one reference electrode; and a computer configured to receive electrical signals from said at least one active electrode and said at least one reference electrode, and process the electrical signals.

Apparatus and methods are described herein that provide a vibratory device that can apply a vibratory signal to a portion of a head of a user such that the vibratory signal can be conducted via bone to a vestibular system of the user and cause a portion of the vestibular system to move in a manner equivalent to that of a therapeutically effective vibratory signal applied to an area overlaying a mastoid bone of the user. The vibratory device can be associated with frequencies less than 200 Hz. The vibratory device can be effective at treating a physiological condition associated with the vestibular system.

The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameters (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).