Compounds of Formula I

##STR00001##

or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided.

Compounds of Formula I

##STR00001##

or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided.

There is provided a neurostimulator and method for delivering to a subject a stimulation in response to a predicted or detected condition. The neurostimulator including: a power circuit for providing electrical power to the neurostimulator; a recording array having a plurality of electrodes for recording a plurality of neurophysiological signals corresponding to a plurality of sites of the subject; a signal processor configured to: determine a phase synchrony among the neurophysiological signals; and associate selected phase synchrony calculations with the prediction or detection of a neurological or neurophysiological condition; and one or more stimulators for delivering to the subject a stimulation in response to the predicted or detected condition.

There is provided a neurostimulator and method for delivering to a subject a stimulation in response to a predicted or detected condition. The neurostimulator including: a power circuit for providing electrical power to the neurostimulator; a recording array having a plurality of electrodes for recording a plurality of neurophysiological signals corresponding to a plurality of sites of the subject; a signal processor configured to: determine a phase synchrony among the neurophysiological signals; and associate selected phase synchrony calculations with the prediction or detection of a neurological or neurophysiological condition; and one or more stimulators for delivering to the subject a stimulation in response to the predicted or detected condition.

A human body support, such as a chair, has a plurality of electrodes arranged in an array and spaced longitudinally with respect to the human body. The array extends from an inferior position to a more superior position along the body. A sensor measures a parameter of the human body that is capable of indicating the presence of drowsiness. A controller has an input connected to the sensor for receiving a signal representing the sensed parameter and has outputs connected to each of the electrodes. The controller detects whether the sensed parameter is within a range indicating the presence of drowsiness and applies a wave of electrical stimuli against the human body in response to detection of a sensed parameter within the range. The electrical stimuli cause periodic tightening and relaxing of proximate muscles as the wave progresses in a direction from an inferior location on the human body toward a more superior location.

A human body support, such as a chair, has a plurality of electrodes arranged in an array and spaced longitudinally with respect to the human body. The array extends from an inferior position to a more superior position along the body. A sensor measures a parameter of the human body that is capable of indicating the presence of drowsiness. A controller has an input connected to the sensor for receiving a signal representing the sensed parameter and has outputs connected to each of the electrodes. The controller detects whether the sensed parameter is within a range indicating the presence of drowsiness and applies a wave of electrical stimuli against the human body in response to detection of a sensed parameter within the range. The electrical stimuli cause periodic tightening and relaxing of proximate muscles as the wave progresses in a direction from an inferior location on the human body toward a more superior location.

System and method for aiding communication for subjects suffering from paralysis of muscles controlled by peripheral nervous system are disclosed. A method for aiding communication for said subjects includes capturing, from a plurality of sensors, sensor data generated based on an interaction of a subject with an interactive UI. The plurality of sensors includes one or more body-parts movement tracking sensors for tracking motion of body-parts of the subject and one or more physiological signal sensors for monitoring physiological signals generated from the subject during the interaction. A plurality of model parameters indicative of characteristics of the subject related to the interaction are determined based on the sensor data. The navigation at the interactive UI is controlled on the plurality of model parameters.

System and method for aiding communication for subjects suffering from paralysis of muscles controlled by peripheral nervous system are disclosed. A method for aiding communication for said subjects includes capturing, from a plurality of sensors, sensor data generated based on an interaction of a subject with an interactive UI. The plurality of sensors includes one or more body-parts movement tracking sensors for tracking motion of body-parts of the subject and one or more physiological signal sensors for monitoring physiological signals generated from the subject during the interaction. A plurality of model parameters indicative of characteristics of the subject related to the interaction are determined based on the sensor data. The navigation at the interactive UI is controlled on the plurality of model parameters.

A system for monitoring erectile dysfunction of a user includes a penile device configured to be accommodated on penis to evaluate penile tumescence, rigidity, and bio-impedance of penile shaft of the penis; and a head-band device implemented as a sleeping mask with electrodes strategically placed around the eyes of the user for detecting sleep characteristics, electrooculography (EOG), and electroencephalography (EEG). A computing device is operatively coupled to penile device and the head-band device to detect condition of rapid eye movement (REM) sleep phase and a condition of penile tumescence, and to actuate the penile devise to measure rigidity of the penile shaft to qualify condition of the erectile dysfunction as organic or inorganic.

Aspects of the present disclosure provide methods, apparatuses, and systems for dynamically masking audible breathing noises determined to be generated by one or more sleeping partners. According to aspects, a subject's sleep is protected by detecting audible breathing noises in a sleeping environment, determining the audible breathing noises are not generated by the subject, and mitigating the perception of the audible breathing noises that are determined to originate from another subject, such as a bed partner, pet, etc. The dynamic masking reduces the subject's exposure to unnecessary sounds and reduces the chances of masking sounds disturbing the subject's sleep.