Methods for the diagnosis, prognosis, patient stratification and prediction of pharmacological response in patients afflicted by psychiatric disorders based on electroretinography (ERG) parameters are described.

The present invention provides a light-weight wearable sensor that can capture electroencephalogram (EEG or brain signals), electromyography (EMG or muscle signal), and electrooculography (EOG or eye movement signal) using a pair of modified off-the-shelf earplugs. The present invention further provides a supervised non-negative matrix factorization learning algorithm to analyze and extract these signals from the mixed signal collected by the sensor. The present invention further provides an autonomous and whole-night sleep staging system utilizing the sensor's outputs.

Methods and systems incorporating non-linear dynamic (NLD) analysis such as entropy or other complexity analysis monitoring continuous or evoked signals from a biological subject are presented, where such a system comprises of processing steps including: a) the combination of a biological signal evoked as a result of patient stimulation presented to a biological subject and a non-linear analysis method capable of capturing temporal changes in signal order or regularity; b) any combination of processed evoked or continuous central nervous or peripheral physiological mechanisms b) a means to generate a measure indicative of a patient's level of anaesthesia and consciousness depth (A&CD), sedation or sleep/wake state. Methods and systems incorporating a NLD analysis means to improve the discrimination between different signals origins including any combination of: a) central nervous system (CNS), b) peripheral control or nervous system (PNS), c) autonomic control or nervous system (ANS), d) arousals, and e) artifacts.

A waveguide apparatus includes a planar waveguide and at least one optical diffraction element (DOE) that provides a plurality of optical paths between an exterior and interior of the planar waveguide. A phase profile of the DOE may combine a linear diffraction grating with a circular lens, to shape a wave front and produce beams with desired focus. Waveguide apparati may be assembled to create multiple focal planes. The DOE may have a low diffraction efficiency, and planar waveguides may be transparent when viewed normally, allowing passage of light from an ambient environment (e.g., real world) useful in AR systems. Light may be returned for temporally sequentially passes through the planar waveguide. The DOE(s) may be fixed or may have dynamically adjustable characteristics. An optical coupler system may couple images to the waveguide apparatus from a projector, for instance a biaxially scanning cantilevered optical fiber tip.

A waveguide apparatus includes a planar waveguide and at least one optical diffraction element (DOE) that provides a plurality of optical paths between an exterior and interior of the planar waveguide. A phase profile of the DOE may combine a linear diffraction grating with a circular lens, to shape a wave front and produce beams with desired focus. Waveguide apparati may be assembled to create multiple focal planes. The DOE may have a low diffraction efficiency, and planar waveguides may be transparent when viewed normally, allowing passage of light from an ambient environment (e.g., real world) useful in AR systems. Light may be returned for temporally sequentially passes through the planar waveguide. The DOE(s) may be fixed or may have dynamically adjustable characteristics. An optical coupler system may couple images to the waveguide apparatus from a projector, for instance a biaxially scanning cantilevered optical fiber tip.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

The present specification describes methods and systems for tracking vision performance, using various techniques such as and not limited to electrooculography. A modular device is integrated with frames of eyeglasses that can be worn by a user. The device incorporates one or more biosensors such as EOG sensors. EOG recording may be used to estimate eyelid and eye motion, and eye gaze direction. The modular device may be fitted into new eyewear or retrofitted into existing eyewear for tracking eyes of the wearer. Embodiments of the present specification provide systems and methods to enable seamless integration of eye tracking into everyday life to maximize productivity and performance.

Low-power multi-stage amplifiers are provided for capacitive reading of low-amplitude and low-frequency signals. An exemplary multi-stage amplifier comprises a plurality of amplification stages, wherein each of the amplification stages comprises an amplifying transistor and an active load, wherein substantially all of the amplification stages have one or more of an increasing DC bias level and a decreasing DC bias level relative to a prior stage, and wherein an output of a given one of the amplification stages is directly applied as an input to a subsequent one of the amplification stages.

A system for acquiring an electrical signal comprises: a plurality of electrodes, a plurality of signal quality detectors, each detector, being configured to detect a signal from a pair of electrodes and each detector comprising an analog-to-digital converter for providing a digital representation of a first resolution of the detected signal; a signal selection logic for determining at least one quality measure of each of the digital representations for selecting a pair of electrodes for signal acquisition; a multiplexer for selecting a pair of electrodes for signal acquisition based on a control signal from the signal selection logic; and a signal processing unit for performing analog-to-digital conversion on the selected signal and providing a digital representation having a second resolution, which is higher than the first resolution.