The invention is a method of automatically adjusting a retinal electrode array to the neural characteristics of an individual patient. By recording electrically evoked electroretinograms (eERG) to a predetermined input stimulus, one can alter that input stimulus to the needs of an individual patient. A minimum input stimulus is applied to a patient, followed by recording the eERG response to the input stimulus. By gradually increasing stimulus levels, one can determine the minimum input that creates a neural response, thereby identifying the threshold stimulation level. One can further determine a maximum level by increasing stimulus until a predetermined maximum neural response is obtained. However, eERG signals include a significant amount of noise. Applicants have developed novel techniques for artifact reduction and noise filtering to provide an accurate measure of neural activity.

A device disclosure includes a unit that measures an eye potential; and a unit that sets a threshold coefficient based on a frequency characteristic value of eye potential differential values and sets an upper threshold and a lower threshold based on a number obtained by multiplying a standard deviation of the eye potential differential values by the threshold coefficient, and detects a change in the eye potential differential values as the eyeblink waveform wherein the change occurs in the time-series data on the eye potential differential values either when the eye potential differential value becomes larger than the upper threshold and, after that, changes from the upper threshold to the lower threshold within a predetermined time or when the eye potential differential value becomes smaller than the lower threshold and, after that, changes from the lower threshold to the upper threshold within the predetermined time.

A method for providing electrical stimulation to a user, the method comprising: providing an electrical stimulation device, in communication with a controller, at a head region of the user; with the electrical stimulation device, providing a stimulation treatment having a waveform configured for neuromodulation in the user; with the controller, performing an adjustment to the stimulation treatment, wherein performing the adjustment includes: generating a transformed waveform with application of a transfer function to the waveform, wherein the transfer function scales the waveform and selectively attenuates extreme waveform values while maintaining a frequency characteristic of the waveform in the transformed waveform; and applying the transformed waveform with the electrical stimulation device, thereby modulating the stimulation treatment.

A pattern stimulus system is described that includes a hemispherical concave surface, a plurality of illumination sources, and a controller. The illumination sources are arranged on the hemispherical concave surface in a plurality of annular rows and a plurality of radial columns. The control is configured to operate the illumination sources to display a checkerboard pattern by illuminating a first subset of the illumination sources and dimming a second subset of the illumination sources. The control is further configured to invert the checkerboard pattern by dimming the first subset of the illumination sources and illuminating the second subset of the illumination sources. Methods are also described for using the pattern stimulus system to evaluate a condition of the eye and to diagnose diseases of the eye.

A system for monitoring biometric signals of a user comprising: a garment configured to be worn by the user and comprising a mounting module having an array of connection regions; a set of biometric sensors coupled to the garment and configured to communicate with the array of connection regions to receive and transmit biometric signals indicative of muscle activity of the user; and a portable control module configured to couple to the garment in a first configuration and to decouple from the garment in a second configuration and comprising: a housing comprising an array of openings; a set of contacts, each including a first region that hermetically seals at least one of the array of openings and couples to at least one of the array of connection regions in the first configuration, and an electronics subsystem coupled to the housing and in communication with a second region of each contact.

A method of generating map data comprises capturing an image of a field of view of a user, extracting a set of map points based on the captured image, identifying respective sets of sparse points and dense points based on the extracted map points, performing point normalization of the respective sets of sparse points and dense points, generating sparse and dense point descriptors for the respective sets of sparse points and dense points, and combining the sparse point descriptors and dense point descriptors to store as map data.

A method of generating map data comprises capturing an image of a field of view of a user, extracting a set of map points based on the captured image, identifying respective sets of sparse points and dense points based on the extracted map points, performing point normalization of the respective sets of sparse points and dense points, generating sparse and dense point descriptors for the respective sets of sparse points and dense points, and combining the sparse point descriptors and dense point descriptors to store as map data.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a neural stimulation system that receives an indication of an ambient audio signal detected by a microphone. The system selects, from a profile, an audio signal including a fixed parameter and a variable parameter. The system sets the variable parameter to a first value. The system generates an output signal based on the fixed parameter and the first value, and provides the output signal to the speaker. The system measures a physiological condition of the subject, adjusts the variable parameter to a second value, generates a second output signal based on the fixed parameter and the second value of the variable parameter, and provides the output signal to the speaker to cause the speaker to provide modified sound to the subject.

A waveguide apparatus includes a planar waveguide and at least one optical diffraction element (DOE) that provides a plurality of optical paths between an exterior and interior of the planar waveguide. A phase profile of the DOE may combine a linear diffraction grating with a circular lens, to shape a wave front and produce beams with desired focus. Waveguide apparati may be assembled to create multiple focal planes. The DOE may have a low diffraction efficiency, and planar waveguides may be transparent when viewed normally, allowing passage of light from an ambient environment (e.g., real world) useful in AR systems. Light may be returned for temporally sequentially passes through the planar waveguide. The DOE(s) may be fixed or may have dynamically adjustable characteristics. An optical coupler system may couple images to the waveguide apparatus from a projector, for instance a biaxially scanning cantilevered optical fiber tip.

A waveguide apparatus includes a planar waveguide and at least one optical diffraction element (DOE) that provides a plurality of optical paths between an exterior and interior of the planar waveguide. A phase profile of the DOE may combine a linear diffraction grating with a circular lens, to shape a wave front and produce beams with desired focus. Waveguide apparati may be assembled to create multiple focal planes. The DOE may have a low diffraction efficiency, and planar waveguides may be transparent when viewed normally, allowing passage of light from an ambient environment (e.g., real world) useful in AR systems. Light may be returned for temporally sequentially passes through the planar waveguide. The DOE(s) may be fixed or may have dynamically adjustable characteristics. An optical coupler system may couple images to the waveguide apparatus from a projector, for instance a biaxially scanning cantilevered optical fiber tip.