A method of determining olfactory perception signature of a subject is disclosed. The method comprises: providing the subject with a plurality of physical odorant samples for sniffing; for each sniffed odorant sample, presenting to the subject, by a user interface, a set of odorant descriptors and a respective set of rating controls, and receiving ratings entered by the subject using the rating controls. Each rating is indicative of a descriptiveness of a respective odorant descriptor for the odorant sample, thereby obtaining a set of descriptiveness levels for the odorant sample. The method also comprises calculating, by a computer, relations between pairs of sets of descriptiveness levels corresponding to pairs of odorant samples, to provide a vector of relations, wherein the vector represents the olfactory perception signature of the subject.

Methods and apparatus provide monitoring of coughing and/or a sleep disordered breathing state of a person. One or more sensors may be configured for non-contact active and/or passive sensing. The processor(s) may extract respiratory effort signal(s) from one or more motion signals generated by active non-contact sensing with the sensor(s). The processor(s) may extract one or more energy band signals from an acoustic audio signal generated by passive non-contact sensing with the sensor(s). The processor(s) may assess the energy band signal(s) and/or the respiratory efforts signal(s) to generate intensity signal(s) representing sleep disorder breathing modulation. The processor(s) may classify feature(s) derived from the one or more intensity signals to generate measure(s) of coughing and/or sleep disordered breathing. The processor may evaluate sensing signal(s) to generate indication(s) of cough event(s) and/or cough type which may include generating an indication of a coronavirus disease or a coronavirus disease cough type.

Disclosed are compositions and methods for measuring olfactory sensitivity, olfactory resolution, and combinations thereof. Such measurements can be made during a single test, or over consecutive tests, which may be performed during a single testing period, such as in a single day, or over a series of testing periods. The tests may be performed by a health care professional, or may be conveniently self-administered by the user.

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for implementing an olfaction training program by an online service executing on a server. A first object and an aroma of the first object is transmitted to the client device of a user that presents the first object in a virtual reality environment and disperses the first aroma. In response, the user interacts with the vital reality environment. The user response is transmitted back to the online service. The user response is stored in a database along with the first data and the first aroma. The online service determines a second object and an aroma of the second obj ect based on the user response. The second object and the aroma of the second object is transmitted to the client device.

A method of assessing a subject including: measuring a plurality of respirations of the subject; determining one or more respiration parameter from the plurality of respirations; and determining, using the one or more respiration parameter, one or more of: a state of consciousness of the subject; and a prognosis of the subject.

The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present invention relates to devices, systems and methods for detecting an asymmetric differential in a patient's olfactory detection threshold (left vs right nostril) which, when present, may be used as a device to detect, diagnose and/or monitor olfactory deterioration resulting from certain neurodegenerative disorders such as Alzheimer's disease.

The invention provides methods and kits for rapid and inexpensive detection of hyposmia or anosmia, diminishment or loss of the sense of smell. Sudden onset of diminishment or loss of the sense of smell is an early sign of infection with SARS-CoV-2, the causative agent of COVID-19; detecting the sudden onset of diminishment or loss of the sense of smell can therefore be used to rapidly screen a population for persons who should undergo diagnostic testing for a SARS-CoV-2 infection, and more generally to screen persons for olfactory disorders.

The present disclosure relates to an apparatus (100) for quantitative assessment of olfactory dysfunctions and neurocognitive deficits, the apparatus includes first filters (104-1) adapted to sterilize air received from an air pump, a second filter (106) filter odor molecules from the air, a manifold (108) adapted to split the sterilized air into a plurality of channels, at least one channel carries the sterilized air to a first MFC (110) and adjacent channels carry sterilized air to second MFCs (112). Each container in a reservoir (114) filled with an odorant different from adjacent containers, and a nozzle (118) adapted to receive the odorized air from the reservoir that is inhaled by a subject through an odor delivery unit (124), based on degree of variation in volumetric concentration of the odorants, quantitative assessment of olfactory dysfunction is determined.

Systems and methods of the present invention provide for an olfactometer for delivering one or more odors and one or more computing devices configured to: receive user input for an odor memory test and an odor discrimination test; calculate a score for the odor memory test and the odor discrimination test; calculate a first and second confidence interval threshold and a second confidence interval threshold for a first and second predicted odor memory score respectively, based on a relationship between, respectively, the odor memory test score and odor discrimination test score, and previously-entered performance data queried from the database; and responsive to the score for the odor memory test not being greater than the first confidence interval threshold and the score for the odor discrimination test not being greater than the second confidence interval threshold, generate a report identifying a user as high risk for a neurodegenerative disease.

An object of the present technology is to accurately determine a motion sickness state of an individual subject. The present technology provides a motion sickness state determination system (1) that includes a first index acquisition unit (12) that acquires biological information of a subject as a first motion sickness state index, a second index acquisition unit (13) that acquires a second motion sickness state index on the basis of movement information regarding a movement of the subject and/or surrounding environment information perceived by the subject, and a motion sickness state determination unit (14) that determines whether or not the subject will be in a motion sickness state or is in the motion sickness state on the basis of the first motion sickness state index and the second motion sickness state index. Furthermore, the present technology also provides a motion sickness state determination device (10), a biological information acquisition device (20), and a surrounding environment information acquisition device (30) included in the system, and a motion sickness state determination method.