A system to improve vestibulo-ocular reflex (VOR) includes a display device; a head motion detector, the head motion detector being configured to detect at least one of a first angular rotational rate of a subject's head or a first acceleration of said subject's head in a first direction; a signal conditioner in communication with the head motion detector; a first gain control in communication with the signal conditioner; a second gain control in communication with the signal conditioner; a motion controller in communication with the display device and the first gain control and the second gain control; and a head motion-inducing device configured to induce a head motion on the subject. The head motion-inducing device includes a motor configured to rotate a head of the subject based on an instruction produced by a data processor.

The present method and system provides a neuromodulation therapy including receiving a plurality of input data relating to a patient, the input data including brain value measurements and body value measurements. The method and system includes analyzing the input data in reference to reference data generated based on machine learning operations associated with existing patient data and reference database data. Based thereon, the method and system includes electronically determining, a brain malady and a severity value for the patient and electronically generating a treatment protocol for the patient, the treatment protocol includes transcranial stimulation parameters. Therein, the method and system includes applying a transcranial stimulation using the transcranial stimulation parameters based on the treatment protocol.

A system for assessing the stability of a person relative to a horizontal surface during an assessment session is provided. The system includes a platform having a stage upon which the person stands. A sensing configuration senses when the person is unbalanced on the stage, and conveys this information to a processor. The processor converts this information into meaningful graphics for viewing on a display.

It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyses. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.

Methods and systems relate to determining sensory motor performance based on user non-postural movements within a generated dynamic virtual environment. The generated environment requires users to: (i) utilize primary sensor inputs (e.g., vision, vestibular sensation and somatosensation); (ii) assess the dynamic virtual environment; and (iii) integrate and translate those inputs into movement to control the dynamic virtual environment. The methods may include receiving non-postural user input with respect to a state of one or more attributes of a dynamic virtual environment provided on a user interface for one or more sessions, the one or more attributes including a control object and a target which moves with respect to the control object; determining performance information based on the user input and the state of the one or more attributes for the one or more sessions; and determining sensory motor performance information from the performance information.

A method and system for monitoring impairment indicators. The method comprises, during a first time window, measuring a first movement signal related to movement of a person with a movement sensor associated with the person, and measuring a first environmental signal with an environmental sensor. The method further comprises electronically storing at least one numerical descriptor derived from the first movement signal and the first environmental signal as reference data for the person. The method further includes, during a second time window, measuring a second movement signal related to movement of the person with the movement sensor and measuring a second environmental signal with the environmental sensor; and comparing at least one numerical descriptor derived from the second movement signal and the second environmental signal to the reference data to identify an impairment indicator.

A method and system for monitoring impairment indicators. The method includes, during a first time window, measuring a first movement signal related to movement of the person with a movement sensor associated with the person, and measuring a first biological signal of the person with a biological sensor attached to the person. The method further includes electronically storing at least one numerical descriptor derived from the first movement signal and at least one numerical descriptor derived from the first biological signal as reference data for the person. The method includes during a second time window, measuring a second signal related to movement of the person with the movement sensor, and measuring a second biological signal of the person with the biological sensor. The method further includes comparing at least one numerical descriptor derived from the second signal and at least one numerical descriptor derived from the second biological signal to the reference data to identify an impairment indicator.

A method for monitoring impairment indicators, the method includes measuring, with a movement sensor attached to the person, a first signal related to movement of a person during a first time window and electronically storing the at least one numerical descriptor derived from the first signal as reference data for the person. The method further includes measuring, with the movement sensor attached to the person, a second signal related to movement of the person during a second time window and comparing at least one numerical descriptor derived from the second signal to the reference data as a factor to identify an impairment indicator. The present disclosure also includes a device for monitoring impairment indicators.

This is a Balance Test device and system for a Modern Functional Reach Test Kit as a system and method for characterizing balance function. The major characteristics are lightweight, compact, durable, lightweight, portable, and rigid. The Balance Test is a non-invasive measuring device used to perform a functional reach test to assess balance and functional motion to help determine if patients are ready to be released from hospital settings.

Methods and compositions are provided for treating or preventing a neurological disease or disorder using an inhibitor of Glyoxalase 1 (GLO1). In some embodiments, the inhibitor is a small molecule. In certain embodiments, the disease or disorder is a sleep disorder, a mood disorder such as depression, epilepsy, an anxiety disorder, substance abuse, substance dependence or substance such as an alcohol withdrawal syndrome.