A method comprising: (a) obtaining information about a period of a fluctuation cycle in an autonomic nerve of a user; and (b) repeating, in a same period as the period of the fluctuation cycle in the autonomic nerve, a process that includes inducing a point of gaze of the user to move in a direction away from the user and inducing the point of gaze of the user to move in a direction to approach the user, according to the obtained information. The period of the fluctuation cycle in the autonomic nerve is a period of a fluctuation cycle in a diameter of a pupil of the user, a period of a fluctuation cycle in a heart beat of the user, or a period calculated from the period of the fluctuation cycle in the diameter of the pupil and the period of the fluctuation cycle in the heart beat.

A method includes: (a) obtaining information about a period of a fluctuation cycle in an autonomic nerve of a user at rest; (b) inducing the user to breaths in synchronization with the period of the fluctuation cycle in the autonomic nerve according to the obtained information; and (c) synchronizing a fluctuation in a diameter of a pupil of the user with the period of the fluctuation cycle in the autonomic nerve at the same time of (b) according to the obtained information. The period of the fluctuation cycle in the autonomic nerve is a period of a fluctuation cycle in the diameter of the pupil, a period of a fluctuation cycle in a heart beats of the user, or a period calculated from the period of the fluctuation cycle in the diameter of the pupil and the period of the fluctuation cycle in the heart beats.

In some aspects, the disclosure relates to a prepulse inhibition (PPI) assay comprising the steps of, administering a tactile prepulse to a human subject, administering a startle stimulus to the subject, and measuring the subject's response to the startle stimulus. In another aspect, the disclosure relates to a method for evaluating tactile hypersensitivity and/or sensorimotor impairment in a human subject, comprising, administering to the subject a PPI assay according to any one of the preceding claims, comparing the assay results to neuro-typical controls, and determining the degree of tactile hypersensitivity and/or sensorimotor impairment in the subject.

A computing system may monitor a patient's biomarkers pre-surgery and/or in-surgery and predict an adhesion complication. The computing system may obtain measurement data associated with one or more patient biomarkers via one or more sensing systems, predict an adhesion complication based on the measurement data associated with the one or more patient biomarkers, and generate an output based on the predicted adhesion complication. The adhesion complication may be predicted by determining a probability of a chronic inflammation response based on the measurement data associated with the one or more patient biomarkers. The generated output may include a control signal configured to indicate an adjustment to an instrument selection for dissecting capability and/or access capability. The generated output may include a control signal configured to notify a surgeon of a probability of an adhesion complication.

An example system includes an analyzer to identify first activity in first neuro-response data, the first activity generated in response to exposure of a subject to a first stimulus prior to exposure to an advertisement or entertainment; identify second activity in second neuro-response data, the second activity generated in response to re-exposure of the subject to the first stimulus after to exposure to the advertisement or entertainment; calculate a differential event related potential measurement; and calculate a differential event related power spectral perturbation. The example system includes a resonance estimator to determine a subject resonance measurement to the advertisement or the entertainment based on the differential event related potential measurement and adjust at least one of the subject resonance measurement or the differential event related potential measurement based on the differential event related power spectral perturbation to generate an adjusted subject resonance measurement.

An apparatus for measuring arterial pulse and heart rate of a subject includes a wearable sensor assembly configured to be attached to the subject to measure the blood pressure of the subject. The apparatus further includes a signal processor configured to receive blood pressure data from the wearable sensor assembly and to perform time-series analysis on the blood pressure data. The processor then determines baroreflex functionality of the patient, from the blood pressure data. Further, the processor determines an indication of hypertension in the subject from the baroreflex functionality.

A system and methods utilizing electrical stimulation to achieve a desired therapeutic effect are provided. In one aspect, a method for controlling nerve activity in a subject is provided. The method includes receiving input indicating a desired therapeutic effect for at least one neural structure of a subject, and selecting, based on the input received, an electrical stimulation configured to achieve the desired therapeutic effect. The method also includes controlling a sympathetic nerve activity in the subject by delivering the electrical stimulation using electrodes positioned proximate to nerves innervating the subject's skin.

A system for neuromodulation or neurostimulation comprising at least one sensing unit configured to provide a sensor signal correlating with a physiological value describing neurological function or dysfunction of a patient, at least one control unit, at least one stimulation unit, and at least one of at least one Central Nervous System stimulation module for providing Central Nervous System stimulation or at least one Peripheral Nervous System stimulation module for providing Peripheral Nervous System stimulation, wherein the control unit is configured to detect the neurological dysfunction based on the sensor signal and to trigger the neuromodulation or neurostimulation. The disclosure further relates to a method for providing neuromodulation or neurostimulation and the use of a neuromodulation system in the method for the treatment of a patient.

In some embodiments, a method includes receiving first physiological data of sympathetic nervous system activity and establishing a baseline value of at least one physiological parameter by training at least one machine learning model using the first physiological data. The method further includes receiving, from a first monitoring device attached to a subject, second physiological data of sympathetic nervous system activity in the subject. Using the at least one machine learning model and based on the baseline value of at least one physiological parameter, the method includes analyzing the second physiological data to predict an agitation episode of the subject and sending a signal to a second monitoring device to notify of the prediction of the agitation episode of the subject such that treatment can be provided to the subject to decrease sympathetic nervous system activity in the subject.

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.