Apparatus, methods, and systems for receiving physiological measurements relating to a user, wherein the physiological measurements comprise heart beat measurements; determining, based on intervals between peaks of the physiological measurements, a first physiological pattern; determining a cognitive activation score based on a comparison between the first physiological pattern and a baseline physiological pattern of the user, wherein the baseline physiological pattern relates to a baseline state of the user and the first physiological pattern relates to a first emotional or cognitive state of the user.

A stress evaluation and calibration method and apparatus, and a storage medium are disclosed. The stress evaluation and calibration method includes: obtaining a physiological parameter signal of a user; determining a smallest stress state value of the user within preset duration based on an eigenvalue vector of the physiological parameter signal and a stress evaluation system; determining calibration information based on a smallest reference stress value of a group to which the user belongs and the smallest stress state value; and calibrating, by using the calibration information, a stress state value output by the stress evaluation system, to determine a theoretical stress state value of the user. With the stress evaluation and calibration method and apparatus, a stress evaluation result can be automatically calibrated, to improve evaluation accuracy, and active participation of the user is not required, to improve user experience.

An apparatus for measurement of skin-to-skin contact between a neonate and a parent of the neonate may comprise a capacitive touch sensor module configured to receive signals from a first electrode and a second electrode, and produce detected contact information associated with the electrodes. The apparatus may further comprise a temperature module configured to measure a temperature of an object within a field of view of the temperature sensor, and to generate a corresponding temperature code. The apparatus may further comprise a clock module configured to time-stamp each collected data sample with a time-of-day code and store the time-stamped data sample on an associated data storage device. The apparatus may further comprise a processor configured to execute computer code instructions that cause the apparatus to coordinate operation of the capacitive touch sensor module, the temperature module, and the clock module.

A wearable device attached to a subject includes an accelerometer that measures acceleration information, and a biological sensor that measures biological signal information of the subject. From the measured acceleration information and biological signal information, first feature data corresponding to a first predetermined period and second feature data corresponding to a second predetermined period are extracted. By machine learning based on the first feature data, a dynamic/static activity identification model, a dynamic-activity identification model, and a static-activity identification model, for the subject, are generated. By combination of results of determination based on each of the identification models, a posture and an activity of the subject are identified, and correspondence information, which associates the identified posture and activity with the biological signal information of the subject, is generated.

Methods for treating a human patient diagnosed with cancer with therapeutic neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological processes associated with the progression of cancer. One aspect of the present technology is directed to methods that attenuate neural traffic along target sympathetic nerves innervating tissue proximate a primary malignant tumor. Other aspects are directed to methods that at least partially inhibit sympathetic neural activity in a renal nerve of a patient diagnosed with cancer or who has a high risk of developing cancer. Targeted sympathetic nerve activity can be attenuated to improve a measurable physiological parameter corresponding to the progression of cancer in the patient. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.

An autonomic nerve index calculation system for calculating an autonomic nerve index of a living body according to an embodiment of the present disclosure generates pulse wave waveform data using at least one pulse wave signal of the living body, filters the generated pulse wave waveform data in at least one predetermined frequency band, converts the filtered pulse wave waveform data into a complex number and calculate pulse wave complex waveform data of the at least one frequency band, and calculates the autonomic nerve index of the living body in the at least one frequency band based on the calculated pulse wave complex waveform data.

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers. One aspect includes a comparison of baseline and post-modulation levels of one or more biomarkers in bodily fluid that have each been collected from a human subject at a relevant time, and that may be used to assess the neuromodulation efficacy. The post-neuromodulation levels for the one or more biomarkers may be collected from the human subject within about 5 minutes to about 14 days post-neuromodulation.

A computer-implemented method for assessing peripheral arterial tone (100), PAT, of an individual (1) monitored by optical plethysmography and for detecting therefrom occurrence of a sleep-related event, comprising:—obtaining: o an optical plethysmography signal (101) measured at an investigated volume (11); and o light intensities (102;103) acquired at two or more points in time (12;13) along said optical plethysmography signal (101);—determining changes in arterial blood volume (16) in said investigated volume (11) between said two or more points in time (12;13) by determining a logarithm (17) or a function approximation thereof (17) of a function of said light intensities (102;103), thereby assessing PAT (100) of said individual (1); and—determining a drop in said PAT (100) indicative for a vasoconstriction of arteries and arterioles in said investigated volume (11), thereby detecting occurrence of a sleep-related event.

In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the saphenous and/or tibial nerves. The stimulation could include burst stimulation, and involve receiving an input relating to autonomic nervous system activity of the patient, and modifying at least one brain or spinal cord autonomic feedback loop relating to bladder function based on the input to balance parasympathetic and sympathetic nervous system activity of the patient.

A cardiovascular health assessment score, representing a working tissue flow and indicating the dependence on central and peripheral control mechanisms, is generated by the evaluation system and used to support a variety of individualized medicine and health applications. One or more of the individualized medicine and health applications may be implemented as part of the evaluation system and incorporate the cardiovascular health assessment.