A method for Heart Rate Variability monitoring and scoring, comprising, collecting, by one or more sensors, sensor data measuring a user's heart beat activity over time, analyzing the sensor data to measure the inter-beat intervals of the heart beat activity to store Heart Rate Variability (HRV) data, creating an HRV scaled score from said HRV data representing, at least in part, said user's particular balance of parasympathetic and sympathetic nervous system activity, presenting said HRV scaled score to said user on a device in combination with one or more recommended actions related to said HRV scaled score.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods include evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

Provided herein are methods, devices and compositions for assessing neuromodulation efficacy based on changes in the level of one or more biomarkers in plasma or urine collected from a human subject following a renal neuromodulation procedure.

Systems and methods for use in measuring sympathetic nervous system activity or blood vessel autoregulation corrected for sympathetic activity. The choroid in the human eye is imaged and, using the resulting image, the vascular perfusion density (VPD) in the choroid is measured. VPD provides a measurement that is directly related to sympathetic nervous system activity. The effect of stimuli on sympathetic nervous system activity can be measured by comparing pre-stimuli VPD measurements with post-stimuli measurements. Quantifying VPD can be performed by determining pixel density within specific areas of the choroid image. Altered sympathetic nervous system activity can be detected in a subject by comparing that subject's VPD measurements to baseline VPD measurements from healthy individuals. Blood vessel autoregulation can be measured by imaging changes in other blood vessels in the eye and correcting with choroid VPD measurements of sympathetic activity.

The present disclosure discusses a nerve cuff that includes a thin-film elastic mesh with an integrated array of electrodes. The nerve cuff can wrap around a human carotid artery or other tissue to stimulate the autonomic nervous system. The nerve cuff can include a housing that secures the mesh to the carotid artery or other tissue.

A method (100) for estimating sympathetic arousal of a subject, the method (100) comprising the steps of: obtaining physiological data (500) from the subject (102), the physiological data (500) including at least one of galvanic skin response data, skin blood perfusion data, and heart rate data of the subject; processing the physiological data (500) to determine one or more features of the physiological data (500); providing the one or more features of the physiological data (500) to a correlation engine (300), the correlation engine (300) configured to correlate the one or more features of the physiological data (500) with a database (400) representing sympathetic nervous activity signals to estimate a sympathetic nervous activity level of the subject; and generating an output of the estimated sympathetic nervous activity level of the subject.

Systems and methods for assessing sympathetic nervous system (SNS) tone for renal neuromodulation therapy are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a detector attached to or implanted in a patient and a receiver communicatively coupled to the detector. The detector can measure cardiac data and the receiver and/or a device communicatively coupled thereto can analyze the cardiac data to provide one or more SNS tone indicators. The SNS tone indicators can be used to determine whether a patient will be responsive to a neuromodulation therapy and/or whether a neuromodulation therapy was effective.

Methods, devices and systems are described for evaluating an initial orthostatic response of an individual during an orthostatic test. For example, the method may include: receiving a pulse signal obtained during an orthostatic test performed from a sensor placed on the individual; identifying a position and an amplitude of the dicrotic notch for pulses in a portion of the pulse signal to obtain a set of dicrotic notch positions and amplitudes; generating an initial orthostatic response curve from the set of dicrotic notch positions and amplitudes; evaluating the initial orthostatic response curve to obtain an assessment of the initial orthostatic response; and displaying, storing and/or transmitting at least one of the initial orthostatic response curve and a visual representation of the assessment of the initial orthostatic response curve.

An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

A system for electro-therapeutically treating a patient includes a stimulatory device electromagnetically coupled with the nervous system of a patient, an electrical power supply, and a control mechanism structured to energize the stimulatory device by way of the electrical power supply at a stimulation frequency. The control mechanism is further structured to control the energizing so as to produce a treatment signal encoded in the energizing and having a treatment signal frequency equal to or less than the stimulation frequency.