A method for testing a human physical function uses a system wearable on the head of a wearer. A first sensor of the system, which is wearable on a lateral first side of the head, carries out a measurement of a first parameter, which gives information about sweat secreted on the first side of the head. A second sensor of the system, which is wearable on a second side of the head opposite to the first side, carries out a measurement of a second parameter, which gives information about sweat secreted on the second side of the head. A final parameter is ascertained for unilateral anhidrosis of a wearer of the system on the basis of the first parameter and the second parameter. An arrangement for testing a human physical function and a system wearable on the head of a wearer are also provided.

A signal processing system includes a heartbeat information acquisition unit, a representative value calculation unit, and a nerve recognition unit. The heartbeat information acquisition unit acquires, from a radio wave sensor, heartbeat information as a result of detection of a person's heartbeat. The representative value calculation unit calculates, based on the heartbeat information, a representative value of an interval of the heartbeat during a predetermined period. The nerve recognition unit recognizes, based on the representative value, a condition of the person's autonomic nervous system.

Equipment for carrying out cardiac autonomic neuropathy tests includes a base unit to which a mouthpiece is connected, forming an autonomous system for measuring the pressure and/or the pattern of breath, provided with a series of LEDs aimed at informing a patient, who is undergoing the test, about correctness or incorrectness of a test execution. The mouthpiece is provided with a flow sensor, aimed at measuring a patient's pattern of breath, and a pressure sensor. The mouthpiece includes also an atmospheric pressure sensor aimed at measuring the environmental pressure. The equipment includes also a sensor, aimed at measuring the heartbeat, applied by simple contact to the patient's wrist area, and an orthostatic measuring device aimed at measuring any change of the patient's position. Data can be introduced or analysed and the type of exam to do can be selected. Results of the tests can be stored in a memory.

A method and an apparatus for analyzing heart rate Variability (HRV), and use thereof are provided. A low-cost, portable and wearable signal acquisition device is utilized to acquire electrocardiography (ECG) signals of epilepsy patients for 24 hours before treatment, and a time domain index, a frequency domain index and a nonlinear index of the ECG during a long term and during a short term are calculated with a programmed HRV analysis method, and the efficacy of vagus nerve stimulation (VNS) treatment for patients with medically intractable epilepsy is accurately and efficiently predicted based on characteristic parameters for characterizing an effect level of the vagus nerve regulating the heart rate, i.e., vagus nerve activity, thereby avoiding unnecessary costs and avoiding the delay of the optimal treatment timing. In addition, the characteristic parameters obtained by the HRV analysis on the ECG may be utilized to clearly select VNS treatment indication patients.

Devices and methods are described herein for treating cardiac conditions using electrical stimulation delivered to and sensing nerve activity from one or both of the AV node and nerve tissue innervating the AV node using one or more neural electrodes positioned in a location within the triangle of Koch of the right atrium.

Various examples are provided related to monitoring of nervous system activity. In one example, a method includes obtaining at least one image of a portion of skin of a subject wherein the subject is not in contact with an imaging system and processing the at least one image to determine at least one characteristic of activated sweat pores in the at least one image. The image(s) can include at least one thermal image. The image(s) can be processed to generate at least one enhanced image for the SPA determination. In another example, a system includes an infrared camera that can capture at least one thermal image of a portion of skin of a subject with the system not in contact with the subject and image processing circuitry that can process the at least one thermal image to determine at least one characteristic of activated sweat pores in the thermal image(s).

The invention presents an electrodermal apparatus comprising at least two electrodes (10), each of which is configured to be in contact with a dermal region, and an electronic circuit comprising an analog-to-digital converter and a processor that is configured to execute computer-executable instructions in order to bias the electrodes (10), to measure the current flowing between pairs of electrodes (10), to apply digital preprocessing to the measured electrical signals and to determine the conductance of the dermal layer, wherein the sensor further comprises an accelerometer, delivering electrical signals to the processor, the preprocessing taking into account the level of the signals that are delivered by the accelerometer.

A method of determining a responsiveness of a patient having brain state changes, comprising receiving an indication of a triggering event; administering to the patient, in response to the indication, a test of responsiveness; determining, based upon a result of the test, at least one responsiveness parameter selected from the group consisting of (i) a time of occurrence of a change in the patient's responsiveness, (ii) a duration of a change in the patient's responsiveness; (iii) a magnitude of a change in the patient's responsiveness, (iv) a time interval from the indication of event occurrence to a change in the patient's responsiveness, (v) a type of change in the patient's responsiveness, (vi) an estimation of a seizure severity; (vii) a classification of a seizure into clinical or subclinical; (viii) a classification of a clinical seizure into simple partial, complex partial, or generalized; (ix) an assessment of efficacy of a therapy for the patient's medical condition; (x) an assessment of the state of the disease and formulation of a prognosis for the patient; (xi) an estimation of a risk of injury or death for the patient; and (xii) two or more thereof. A medical device system capable of implementing the method.

A system and method are provided, the system including a monitoring device to monitor sensory data of a patient and to provide a sensory data response thereto, and a control unit configurable to cool or warm circulated fluid through at least one contact pad for thermal exchange with the patient. The monitoring device can be configured to monitor a patient physiological response to a change in temperature of the patient (e.g. pursuant to induced hypothermia therapy), wherein a monitoring signal is provided by the monitoring device. A processor can be provided to process the monitoring signal and provide an output employable by medical personnel. The processor can be programmed to control automatically a temperature of the circulated fluid to cool or warm the patient in different treatment phases in accordance with a predetermined protocol, and process the sensory data signal to provide an output signal indicative of a sensory measurement.

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.