A local wearable brain wave cap device for detection is provided to simultaneously detect brainwave and heart rate variability data of a subject and includes a brain wave detection cap, at least one ear electrode and a transmission unit. The brain wave detection cap includes a wearable device and a plurality of electrode units. The wearable device is suitable for arranging the plurality of electrode units on brain wave positions corresponding to head of a subject. Each of the plurality of electrode units includes an accelerator, a storage unit, an input/output unit and a primary amplifier for detecting a brain wave.

An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.

A physiological information processing apparatus includes a processor and a memory storing computer-readable instructions. When the instructions are executed by the processor, the physiological information processing apparatus obtains physiological information data indicative of physiological information of a subject, obtains a first parameter associated with a vital sign of the subject based on the physiological information data, displays a first trend graph showing temporal change in the first parameter in a first display area of a display screen of a display, obtains a second parameter associated with an autonomic nerve function of the subject based on the physiological information data, and displays a second trend graph showing temporal change in the second parameter in a second display area of the display screen. The first and second display areas are displayed next to each other such that time axes of the first and second display areas are synchronized with each other.

An example of a system for monitoring and treating respiratory distress in a patient may include signal inputs, a signal processing circuit, and a respiratory distress analyzer. The signal inputs may be configured to receive patient condition signals indicative of autonomic balance of the patient. The signal processing circuit may be configured to process the patient condition signals and to generate patient condition parameters indicative of the autonomic balance using the processed patient condition signals. The respiratory distress analyzer may be configured to determine a state of the respiratory distress using the patient condition parameters, and may include a parameter analysis circuit configured to analyze the autonomic balance of the patient and to determine the state of the respiratory distress using an outcome of the analysis.

Provided is a stress measurement system and a stress measurement method that are capable of measuring the stress level of a subject without taking time and effort. A stress measurement system 1 includes a sensor unit 31 that detects a plurality of detection target gases based on substances contained in a specimen of a subject and outputs a plurality of detection values corresponding to respective detection results of the plurality of detection target gases, and a control unit that determines a stress level of the subject, based on a combination of the plurality of detection values. In addition, the substances contained in the specimen may include a substance serving as a raw material for a brain neurotransmitter.

Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

A biological information displaying apparatus according to an embodiment includes a picture obtaining apparatus and a processor. The picture obtaining apparatus obtains a picture signal of a predetermined site of a subject as a moving image. The processor generates a hue moving image by extracting a luminance or an image-based photoplethysmogram (iPPG) related to a pulse wave for each pixel of the moving image and assigning a hue in accordance with a value of luminance information or iPPG information. The processor displays the generated hue moving image such that the hue moving image is superimposed on an image of the subject.

Disclosed in the present disclosure is a method, system and apparatus for prediction, estimation and prevention of occurrence of agitation episode in a subject predisposed to agitation. The method comprises receiving, from a first monitoring device attached to a subject, physiological data of sympathetic nervous system activity in the subject and activity data of the subject; receiving, from a computing device, a plurality of indications associated with a plurality of agitation episodes of the subject; analyzing, using at least one machine learning model, the physiological data, the activity data, and the plurality of indications to determine a probability of an occurrence of an agitation episode of the subject; and sending a signal to a second monitoring device to notify the second monitoring device of the probability of the occurrence of the agitation episode of the subject such that treatment can be provided to the subject to decrease sympathetic nervous system activity in the subject.

Systems and methods for identifying the most impactful moments or segments of music, which are those most likely to elicit a chills effect in a human listener. A digital music signal is processed using two or more objective processing metrics that measure acoustic features known to be able to elicit the chills effect. Individual detection events are identified in the output of each metric based on the output being above or below thresholds relative to the overall output. A combination algorithm aggregates concurrent detection events to generate a continuous concurrence data set of the number of concurrent detection events during the music signal, which can be calculated per beat. A phrase detection algorithm can identify impactful segments of the music based on at least one of peaks, peak-proximity, and a moving average of the continuous concurrence data.