An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

The biological information detecting apparatus includes a face detecting section detecting the face of a person from an image signal, an expression detecting section detecting an expression of the person from the image signal of the region of the face to calculate an expression feature amount, a pulse wave detecting section detecting a pulse wave of a blood flow of the person from the image signal of the region of the face, a scoring section calculating a score of the expression of the person based on the expression feature amount, a coaching section generating an expression guide, and a display section displaying the expression guide, and the display section further displays biological information indicating a state of the autonomic nerve of the person calculated based on the pulse wave after displaying the expression guide, and the score calculated based on the expression feature amount.

A method includes: (a) obtaining information about a period of a fluctuation cycle in an autonomic nerve of a user at rest; (b) inducing the user to breaths in synchronization with the period of the fluctuation cycle in the autonomic nerve according to the obtained information; and (c) synchronizing a fluctuation in a diameter of a pupil of the user with the period of the fluctuation cycle in the autonomic nerve at the same time of (b) according to the obtained information. The period of the fluctuation cycle in the autonomic nerve is a period of a fluctuation cycle in the diameter of the pupil, a period of a fluctuation cycle in a heart beats of the user, or a period calculated from the period of the fluctuation cycle in the diameter of the pupil and the period of the fluctuation cycle in the heart beats.

A fatigue recovery support apparatus includes a circadian rhythm acquisition module which acquires a circadian rhythm, a pattern determination module which determines the acquired pattern of the circadian rhythm, a sleep determination module which determines a sleep quality, a relational data store which in advance stores relational data presenting a relationship among the circadian rhythm pattern, the sleep quality, and a fatigue recovery effect of sleep, and a recovery effect determination module which estimates the fatigue recovery effect of sleep based on the circadian rhythm pattern, the sleep quality, and the relational data.

Methods are provided for non-invasive early screening of a subject for a neurodegenerative disorder, by analyzing one or more parameters associated with the neurodegenerative disorder.

A cardiovascular health assessment score, representing a working tissue flow and indicating the dependence on central and peripheral control mechanisms, is generated by the evaluation system and used to support a variety of individualized medicine and health applications. One or more of the individualized medicine and health applications may be implemented as part of the evaluation system and incorporate the cardiovascular health assessment.

[Problem to be Solved] To provide a vascular baroreflex-related sympathetic activity detection device, a vascular baroreflex-related sympathetic activity detection program, and a vascular baroreflex-related sympathetic activity detection method capable of detecting vascular baroreflex-related sympathetic activity, which is sympathetic nervous activity of a blood vessel involved in a baroreflex function, in a simple and non-invasive manner.

[Solution] A vascular baroreflex-related sympathetic activity detection device 1 that detects vascular baroreflex-related sympathetic activity, which is sympathetic nervous activity of the blood vessel involved in the baroreflex function, based on pulse wave data on a biological artery and a beat interval corresponding to the pulse wave data, the vascular baroreflex-related sympathetic activity detection device including a VBRSA-series detecting unit 44 that detects, as a vascular baroreflex-related sympathetic activity series indicative of vascular baroreflex-related sympathetic activity, a series where, from among the series in which the beat interval increases or decreases by n (n is a natural number 3 or more) beats consecutively, a correlation coefficient for the beat interval and pulse wave data is greater than any positive threshold up to the (n1)-th beat and the correlation coefficient at the n-th beat falls to or below the threshold.

The present disclosure describes systems and methods to non-invasively determine whether a patient has an autonomic dysfunction. In some implementations, the autonomic dysfunction can be a neurological dysfunction. The system can measure a patient's autonomic nervous system response to a stimulus. The stimulus can be a thermal stimulus, such as a cold temperature. The system can apply the thermal stimulus to an extremity of the patient, such as the patient's hand or arm.

An emotion identification device includes: a first detection unit which detects a central nervous system reaction of a user; a second detection unit which detects an autonomic nervous system reaction of the user; and an identification unit which identifies aggressiveness in anger of the user based on the central nervous system reaction and the autonomic nervous system reaction.

The invention relates to a method for determining at least one blood pressure value of a subject. According to the invention, a heartbeat signal of a subject, in particular an ECG, is determined by means of a heartbeat measuring arrangement and transmitted to a circulation parameter determination unit, wherein the circulation parameter determination unit determines at least one value of an autonomic tone, in particular a vagal tone and/or a heart rate variability and/or a sympathetic tone and/or an autonomic quotient, from a determined time profile of the heartbeat signal, wherein the circulation parameter determination unit determines the at least one blood pressure value taking into account the at least one value of the autonomic tone, and the determined blood pressure value is output.