A blood pressure monitor includes a processor configured to control a cuff pressure and calculate blood pressure information of a subject based on a cuff pressure signal representing the cuff pressure and a pulse wave signal superimposed on the cuff pressure signal. The processor calculates first blood pressure information of the subject who has maintained a recumbent position for a prescribed time period, maintains the cuff pressure at a first pressure lower by a prescribed value than a systolic blood pressure included in the first blood pressure information, determines if an amplitude of the pulse wave signal is equal to or greater than a threshold value when the cuff pressure is maintained at the first pressure and the subject is in an upright position, assesses an autonomic nerve function of the subject based on a result of the determination, and outputs a result of the assessment.

Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including a head mounted display to monitor one or more physiologic signals from the face or head of the subject is disclosed. A method for analyzing an ocular parameter of the subject to determine a sympathetic and a parasympathetic outflow thereto is disclosed.

A wearable biometric sensing ring apparatus for continuous heart rate and blood pressure monitoring having a ring housing for retention on a finger of a user, an electrodermal activity (EDA) sensor disposed within the housing so as to contact a location of the skin of the finger when the housing is retained on the finger, the EDA sensor configured for measuring changes in skin impedance indicative of SNS activation; a biometric sensor disposed within the housing in proximity to the EDA sensor so as to contact at or near the location of the skin of the finger. Application software is provided for assessing the physiological state of the user based on acquired EDA sensor data and biometric sensor data.

An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.

A wearable device is configured to perform stress detection, emotion recognition and emotional management. The wearable device may perform a process that includes monitoring an emotional score of a user, the emotional score computed based on measured biological signals of the user. The device may detect an emotional event from the monitored emotional score. The device may transmit an alert signal to the user in response to the detected emotional event, in which an action plan associates the alert signal with a corresponding action to be performed by the user. The device may evaluate an effectiveness of the action plan by evaluating an impact of the action on the emotional score of the user. The device may determine a change to the action plan based on the evaluated effectiveness of the action plan. Finally, the device may incorporate the determined change into the action plan.

A neurostimulation system comprises a control system configured to monitor a patient receiving neurostimulation therapy. The neurostimulation therapy has a stimulation cycle comprising a stimulation ON period, in which the patient is receiving neurostimulation, and a stimulation OFF period, in which the patient is not receiving neurostimulation. The control system is programmed to receive electrocardiogram (ECG) data from the patient receiving the neurostimulation therapy. The control system is further programmed to monitor a heart rate of the patient based on the ECG data over at least one stimulation cycle of the neurostimulation therapy. The control system is further programmed to generate an indication of signal stability to be displayed to a user based on the received ECG data.

Systems and methods for identifying the most impactful moments or segments of music, which are those most likely to elicit a chills effect in a human listener. A digital music signal is processed using two or more objective processing metrics that measure acoustic features known to be able to elicit the chills effect. Individual detection events are identified in the output of each metric based on the output being above or below thresholds relative to the overall output. A combination algorithm aggregates concurrent detection events to generate a continuous concurrence data set of the number of concurrent detection events during the music signal, which can be calculated per beat. A phrase detection algorithm can identify impactful segments of the music based on at least one of peaks, peak-proximity, and a moving average of the continuous concurrence data.

Systems and methods are described herein for determining whether cardiac conduction system pacing therapy may be beneficial and/or determining how proximal or distal a cardiac conduction system block may be using external cardiac signals. To do so, one or more left-sided metrics of electrical heterogeneity information may be generated based on left-sided surrogate cardiac electrical measured using a plurality of left external electrodes.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods include evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.