An example system includes a processor to determine a first distance between a first peak in a first frequency band of neuro-response data gathered from a subject while exposed to media and a second peak in the first frequency band; determine a second distance between a third peak in the first frequency band and either the second peak in the first frequency band or a fourth peak in the first frequency band; determine a first difference between the first distance and the second distance; generate a first response profile for the subject based on the first difference; and integrate the first response profile with a second response profile associated with a second subject to form an integrated response profile. A selector is to select an advertisement or entertainment for presentation based on the integrated response profile. The processor is to modify the media to present the advertisement or entertainment.

Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

Neurostimulation of a mixed nerve comprising a plurality of nerve fibre types. An implantable electrode array comprising a plurality of electrodes is positioned proximal to the mixed nerve. An electrical stimulus is delivered from at least one nominal stimulus electrode of the implantable electrode array, in accordance with a set of stimulus parameters. A recording of the electrophysiological response evoked by the electrical stimulus is obtained from at least one nominal recording electrode of the implantable electrode array. The recording is analysed by assessing one or more selected characteristics of the recording, and from the observed selected characteristics a level of recruitment of one or more fibre types recruited by the electrical stimulus is identified. The stimulus parameters are refined in a manner to effect selective recruitment of one or more fibre types relative to other fibre types of the mixed nerve.

A vehicle rest evaluation device for a vehicle includes a computer. The computer includes a biological information acquirer, an evaluation value calculator, and a notification controller. The biological information acquirer is configured to acquire biological information of a user who rests in the vehicle. The evaluation value calculator is configured to calculate, based on the biological information, an evaluation value for evaluating a balance of an autonomic nervous system of the user. The notification controller is configured to make a comparison between a first evaluation value calculated by the evaluation value calculator and a second evaluation value calculated at a different timing from the first evaluation value and notify the user of a result of the comparison.

Methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by electrical stimulation of a nerve. The method comprises applying a first stimulus to a patient having a medical condition and measuring a first baseline physiological response from the patient. An electrical impulse is applied to a nerve within the patient and second stimulus is applied to the patient. A second physiological response evoked by the second stimulus is measured and compared to the first baseline physiological response. The methods may be used to optimize the placement of a stimulator, to test whether a patient is a suitable candidate for treatment using nerve stimulation, and/or to select the stimulation parameters that optimize acute or chronic treatment.

Methods for treating and managing pain in a patient with therapeutic neuromodulation and associated systems and methods are disclosed herein. Chronic or debilitating pain can be associated, for example, with a disease or condition of the abdominal or reproductive viscera. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a target blood vessel of a diseased or damaged organ of a patient experiencing pain. Targeted sympathetic nerve activity can be modulated at least along afferent pathways which can improve a measurable parameter associated with the pain of the patient The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.

Example methods, apparatus, systems and machine readable media are disclosed herein for analyzing response data from subjects exposed to media. An example method includes collecting electroencephalography data from a brain of a subject exposed to an advertisement. The example method also includes determining neuro-response data from the electroencephalography data, the neuro-response data representative of interaction between a first frequency band and a second frequency band of the electroencephalography data, the second frequency band being different than the first frequency band. In addition, the example method includes determining resonance to the advertisement based on the neuro-response data and identifying one or more priming levels for one or more locations in a source material based on an attribute of the source material. The example method also includes selecting a first one of the one or more locations for inclusion of the advertisement based on the resonance and the priming levels.

A biological body state estimation device configured such that a homeostatic function level is sorted and acquired in plural stages by using a biological signal obtained from an upper body of a person and each stage of the homeostatic function level is plotted in time series in accordance with a time axis indicated on the lateral axis and displayed as a graph by a display. A highest part on the vertical axis of the graph can be displayed as a highly active state and a lowest part as a function decline state. Therefore, a state of fluctuation due to autonomous nerves as an attempt to maintain homeostasis, progress of a feeling of fatigue, and a state stimulated by activation of the brain can be captured as a periodic function. Moreover, a sleep prediction phenomenon can be captured.

An apparatus and a method for monitoring cardiovascular health are provided. The apparatus includes a housing, a control circuitry, an inflatable cuff for surrounding an upper limb of a user, a pump contained in the housing, at least a first electrode and a second electrode, and an ear-worn structure having the first electrode mounted thereon. When performing blood pressure measurement, the processor controls the pump to inflate and deflate the cuff, for measuring blood pressure of the user. When performing electrocardiographic signal measurement, through mounting the ear-worn structure on an ear of the user, the first electrode contacts the skin of the ear or around the ear, and through mounting the cuff surrounding the upper limb, the second electrode contacts the skin of the upper limb, enabling the processor to acquire electrocardiographic signals through the first electrode and the second electrode.

A system for electro-therapeutically treating a patient includes a stimulatory device electromagnetically coupled with the nervous system of a patient, an electrical power supply, and a control mechanism structured to energize the stimulatory device by way of the electrical power supply at a stimulation frequency. The control mechanism is further structured to control the energizing so as to produce a treatment signal encoded in the energizing and having a treatment signal frequency equal to or less than the stimulation frequency.