Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. A controller may be physically connected to the monitoring system from the sterile field to allow the user to control the monitoring system.

A prediction device is configured to perform a prediction method to predict a risk of chemotherapy-induced peripheral neuropathy, CIPN, in a test subject. The prediction method comprises receiving (211) perception data comprising low-frequency vibration perception data, LF-VPD, and operating (214) at least one prediction model on the perception data to determine at least one risk variable, which is indicative of a risk that the test subject will develop peripheral neuropathy as a result of chemotherapy. The LF-VPD designates measured perception of vibrations at one or more predetermined locations on one or more limbs of the test subject, and represents, for vibrations at each of one or more predefined frequencies below 64 Hz, a vibration energy that causes the test subject to switch between perception and non-perception of the vibrations.

A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. A controller may be physically connected to the monitoring system from the sterile field to allow the user to control the monitoring system.

A diagnostic apparatus includes a sympathetic nerve activity level index calculation unit that calculates a sympathetic nerve activity level index indicating a sympathetic nerve activity level, a parasympathetic nerve activity level index calculation unit that calculates a parasympathetic nerve activity level index indicating a parasympathetic nerve activity level, and a disease determination unit that determines a possibility of a cardiovascular disease of a subject on the basis of change tendency of the sympathetic nerve activity level index calculated by the sympathetic nerve activity level index calculation unit and change tendency of the parasympathetic nerve activity level index calculated by the parasympathetic nerve activity level index calculation unit.

A method of neurohydrodissection for reducing a perception of pain in a patient is disclosed. The method comprises a step of physically inspecting the patient and locating a first compression site of a nerve of the patient where the nerve passes through a tissue and is inflamed. The method comprises a step of imaging the patient at the first compression site. The method comprises a step of inserting a syringe at the first compression site, wherein while the imaging the patient at the first compression site occurs, guiding the syringe to an intersection between the nerve and the tissue, injecting a solution with the syringe at the intersection and dissecting the nerve from the tissue.

An intraoperative nerve monitoring system for monitoring nerve activity within a trachea of a patient. The intraoperative nerve monitoring system includes an endotracheal (ET) tube assembly, which includes an ET tube partially inserted within a trachea and a surface electrode wrapped about the ET tube. The ET tube is configured to monitor nerve activity when the ET tube is partially inserted within the trachea and is contacting a target tissue and to output a nerve signal. The intraoperative nerve monitoring system also includes a pressure sensor assembly configured to sense an amount of pressure between the surface electrode and the target tissue and a console including an output device configured to output indicators based on the monitored nerve activity and the sensed amount of pressure to facilitate proper placement of the ET tube in the trachea and to indicate nerve activity.

A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. An evoked stimulation response may be sensed by a sensor near a portion of a subject. The evoked response may be sensed by an electrode and determined with a monitoring system. The evoked response may additionally and/or alternatively be sensed with a motion sensor. A position sensor may be provided to measure or determine whether the sensor has moved during a procedure.

A bipolar stimulation probe includes a first electrode, a second electrode, a control module, and switches. The control module is configured to stimulate nerve tissue of a patient by generating (i) a first output signal indicative of a first pulse to be output from the first electrode, and (ii) a second output signal indicative of a second pulse to be output from the second electrode. The first pulse and the second pulse are monophasic. The switches are configured to output from the bipolar stimulation probe (i) the first pulse on the first electrode based on the first output signal, and (ii) the second pulse on the second electrode based on the second output signal.