At least partial function of a human limb is restored by surgically removing at least a portion of an injured or diseased human limb from a surgical site of an individual and transplanting a selected muscle into the remaining biological body of the individual, followed by contacting the transplanted selected muscle, or an associated nerve, with an electrode, to thereby control a device, such as a prosthetic limb, linked to the electrode. Simulating proprioceptive sensory feedback from a device includes mechanically linking at least one pair of agonist and antagonist muscles, wherein a nerve innervates each muscle, and supporting each pair with a support, whereby contraction of the agonist muscle of each pair will cause extension of the paired antagonist muscle. An electrode is implanted in a muscle of each pair and electrically connected to a motor controller of the device, thereby simulating proprioceptive sensory feedback from the device.

A nervous tissue imaging system and a method therefor. The system includes: a housing containing an excitation light source, optically coupled with a source optical train, the excitation light source emits excitation light in a first wavelength range, which can be in a near ultraviolet light range, to illuminate a tissue region of interest including healthy nervous tissue and healthy non-nervous tissue. The excitation light in the first wavelength range causes the healthy nervous tissue, in response to being illuminated with the excitation light, to endogenously autoflouresce and emit first autofluorescence light at a first luminance in a second wavelength range. The healthy non-nervous tissue, in response to being illuminated with the excitation light, either avoids emitting any autofluorescence light in the second wavelength range; or endogenously autoflouresces and emits second autofluorescence light in the second wavelength range at a second luminance that is lower than the first luminance.

A nerve monitoring system facilitates monitoring an integrity of a nerve.

In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.

According to a measuring method or a control method of life activity, a life object is illuminated with an electromagnetic wave including a wavelength in a designated waveband, and a characteristic in a local area of the life object is detected, or a life activity thereof is controlled. The designated waveband is defined based on phenomena used for detecting or controlling an activity state of the life object or a change of the state. This local area is an area constituted by one or more cells.

Methods and systems are provided for the automated detection and analysis of structural tissue alterations related to myelin and axons/neurons in one or more biological structures of a patient's nervous system obtained from data from a medical imaging system, or the initial sensing or data collection processes such as, those that could be used to generate an image. In some embodiments, the method comprises, at a system having a memory and one or more processor for processing and displaying images of the biological structure, computationally processing at least a T1 weighted magnetic resonance image of the structure and a T2 weighted magnetic resonance image of the structure in order to analyze at least a portion of the structure of the nervous system using a plurality of stored tissue classifier elements to determine if the portion of the structure correlates with the presence of myelin. Such methods are useful for the detection of diseases associated with demyelination.

A method for treating a fibrous mass, which comprises a Morton's neuroma or a plantar firbroma. The method comprises identifying a location of the fibrous mass, determining a first size of the fibrous mass, non-surgically delivering electromagnetic energy to the fibrous mass, and determining a second size of the fibrous mass.

A nerve probe array has a connector made of a flexible material; and a plurality of probes coupled to the connector, each of the plurality of probe having an electrode formed at a body thereof. The plurality of probes are arranged with intervals in a length direction of the connector, and the connector surrounds an outer circumference of a nerve, and the plurality of probes pierce the outer circumference of the nerve and are inserted into the nerve.

A method for assessing nerve health during a spinal decompression procedure includes: accessing a database containing historical patient data; receiving patient data of a target patient; identifying a subset of historical patients with similar pre-operative characteristics; generating an individualized target range for at least one nerve function parameter based on the subset; measuring an actual nerve function parameter of the target patient during the procedure; and displaying a graphical representation of the measured parameter relative to the individualized target range.

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.