The present disclosure relates to a medical diagnostic and delivery device that includes a mouthguard, a dental brace or a denture. The device can be positioned within a mouth or a buccal cavity of a user. A housing of the device can be shaped to be removably secured within the buccal cavity of the user, for example, include grooves shaped and sized to match a dental bite of the user. The device includes a cartridge containing one more substances or medications configured to be delivered to a user in the form a liquid, particles, or fine mist. Any suitable first air medication can be contained within the cartridge such as epinephrine, blood thinners, painkillers, vitamins or any other suitable drugs for limiting the extent of injury.

Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Systems and methods for predicting clinical outcomes of a patient are provided. An input medical image of a tumor of a patient is received. The tumor is segmented from the input medical image. One or more assessments of the tumor are performed based on the segmentation. A clinical outcome of the patient is predicted based on results of the one or more assessments of the tumor. The clinical outcome of the patient is output.

Methods and systems for providing stimulation to a patient's brain using one or more electrode leads implanted in the patient's brain are described. The methods and systems help a clinician determine locations upon the lead where stimulation is expected to provide the best therapeutic benefit and the least side effects. Different locations upon the lead are used to provide stimulation and for each stimulation location evoked potentials are recorded. The evoked potentials are associated with likely beneficial therapeutic stimulation. Signals indicative of unwanted motor activity in the patient are also recorded for each of the stimulation locations. The recorded evoked potential signals and motor signals are used to determine stimulation locations that provide therapeutic benefit with minimal side effects. They can also be used to determine therapeutic windows for the potential stimulation locations.

According to certain aspects, a computer-implemented method for operating an autonomous or semi-autonomous vehicle may be provided. With the customer's permission, an identity of a vehicle operator may be identified and a vehicle operator profile may be retrieved. Operating data regarding autonomous operation features operating the vehicle may be received from vehicle-mounted sensors. When a request to disable an autonomous feature is received, a risk level for the autonomous feature is determined and compared with a driver behavior setting for the autonomous feature stored in the vehicle operator profile. Based upon the risk level comparison, the autonomous vehicle retains control of vehicle or the autonomous feature is disengaged depending upon which is the safer driver—the autonomous vehicle or the vehicle human occupant. As a result, unsafe disengagement of self-driving functionality for autonomous vehicles may be alleviated. Insurance discounts may be provided for autonomous vehicles having this safety functionality.

A diagnostic method for monitoring changes in a fluid medium in a patient's head. The method includes positioning a transmitter at a first location on or near the patient's head, the transmitter generates and transmits a time-varying magnetic field into a fluid medium in the patient's head responsive to a first signal; positioning a receiver at a second location on or near the patient's head offset from the transmitter, the receiver generates a second signal responsive to a received magnetic field at the receiver; transmitting a time-varying magnetic field into the fluid medium in the patient's head in response to the first signal; receiving the transmitted magnetic field; generating the second signal responsive to the received magnetic field; and determining, a phase shift between the transmitted magnetic field and the received magnetic field for a plurality of frequencies of the transmitted time-varying magnetic field.

An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome. These biosignatures and biomarkers that reveal hidden, implicit, and latent brain circuit patterns provoked by fMRI tasks, can also provide for the development of non-invasive diagnostics and targeted therapeutics in neuropsychiatric diseases.

Disclosed are devices, electrodes, systems, methods, and other implementations, including a system that includes a subdural sound comprising an elongated structure configured to be placed within a subdural space of a brain area of a patient, and an electrode comprising an elongated body, a plurality of electrical contacts disposed on a substantially flat first side of the elongated body, and a soundage channel defined along a longitudinal axis of the electrode and open at opposite ends. The soundage channel at the leading end of the electrode is fitted on the trailing end of the elongated structure of the subdural sound so as to be advanced, when the subdural sound is placed within the subdural space, to a target site in the subdural space for tangential placement on target tissue in the subdural space of the brain area.

An input device is to input a shape of a measurement target is response to a signal transmitted from a stylus pen, to determine positional relation between a position of a marker and a shape of the measurement target. The marker is attached to the measurement target and detectable by a cerebral-function measuring device. The input device includes a controller, and a display unit. The controller is configured to generate a screen in which a three dimensional shape of the measurement target and a guide of a position to be acquired next with the stylus pen are superimposed. The display unit is configured to display the screen generated by the controller, on a display portion.

Systems, methods, and devices for automatic generation of a stimulation therapy that mimics electrographic activity in the brain at natural seizure termination define a stimulation therapy to be generated by an implanted component of a medical device system and delivered to a subject through identifying data characterizing a patient's seizures, especially at termination. A machine learning model identifies the seizures or seizure types from which to establish a canonical seizure or seizure type, and an algorithm translates the canonical seizure or seizure type into data that can be used to characterize a stimulation therapy. The systems, methods, and devices, include those configured to deliver the stimulation therapy that emulates the canonical seizure or seizure type when the seizure is detected, with the aim of terminating the seizure sooner than it would terminate without intervention.