A system for performing functional brain mapping includes a memory configured to store first data from a magnetic resonance imaging (MRI) system and second data from electrodes. The system also includes a processor operatively coupled to the memory and configured to identify first edges in a brain network based on the first data from the MRI and second edges in the brain network based on the second data from the electrodes. The processor is configured to determine, based on the first edges and the second edges, connectivity metrics for the brain network. The processor is also configured to generate, based at least in part on the connectivity metrics, a decoder that differentiates between critical nodes and non-critical nodes in the brain network.

Provided according to embodiments of the invention are methods of monitoring the direction of blood flow that include processing with a computer photoplethysmography (PPG) signal streams from a sensor array on a body site of the individual to determine the direction and/or velocity of the blood flow at the body site of the individual. In some embodiments, direction of the blood flow at the body site is determined by the phase difference between at least three PPG signal streams from the sensor array, wherein the at least three PPG signal streams are generated from emissions of the at least three emitters.

An intracellular monitoring device (IMD) that fits completely inside a living cell, and causes no significant impairment, to a cell's normal biological processes. The IMD monitors a cell for its level of a biological substance (e.g., calcium ion concentration) of interest. If the biological substance reaches or exceeds a threshold, the IMD transmits an electromagnetic signal, received by an antenna outside the cell. Each IMD has its electromagnetic signal encoded with a unique frequency. Detection of the frequency components, in the signals received by an antenna, permits identification of the source IMD's. A high calcium ion concentration is indicative of a strongly-activated cerebral cortex neuron. Brain tissue is relatively transparent to near infrared, making it a good frequency band, for the electromagnetic signals from neuron-monitoring IMD's. The near infrared of each IMD can be produced by quantum dots, powered by bioelectric catalysis triggered by high calcium ion concentration.

In each trial, brain electrical activity at multiple points of a target person is measured. An acquirer of a determination device acquires response matrices for n trials under a first condition and response matrices form trials under a second condition. An analyzer performs canonical correlation analysis on the acquired response matrices to obtain first canonical variable time series. A distance calculator calculates a distance between the trials from the obtained first canonical variable time series to obtain a distance matrix. A determiner obtains a possibility that the n trials and the m trials are classified into two different clusters from the distance matrix and determines whether the first condition and the second condition are substantially different. It is possible to provide to a single target person a first content in n trials and a second content in m trials so as to determine a difference in interest of the single target person. It is possible to provide the same content to a first subject who is the target person in n trials and to a second subject who is the target person in m trials so as to determine whether the two are different or the same.

A physical area network for detecting head injuries described herein enables significantly improved cranial health monitoring and treatment by utilizing internal (in-body) mechanisms and information and external mechanisms and information.

A system for monitoring and analyzing impact data to determine consciousness level and injuries, comprising: impact event monitoring device monitors impact event that occurs to first end-user, impact event monitoring device integrated into objects; impact event monitoring device collects impact data of objects, first end-user using sensors, impact sensing unit, motion detection unit, GPS module, image capturing unit; network module send impact data to impact event monitoring and analyzing module, impact event monitoring and analyzing module convert impact data into Yaw, Pitch and Roll data, impact event monitoring and analyzing module analyze Yaw, Pitch and Roll data with machine learning techniques and deep learning techniques; impact event monitoring and analyzing module report and send emergency notifications to second computing device, impact data accessing module enable second end-user to examine location and intensity of impact event to understand consciousness level and injuries for providing better treatment to first end-user.

A ferrule is configured to optically coupled to electronics for detect signals from a head of a user. The ferrule has optical properties to guide light between the electronics and a head of a user. The ferrule comprises a base portion having a cavity to enclose an optical element, a middle portion configured to guide light to or from the optical element, and a tip portion to interface with the head of the user.

Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.

A measurement probe for preschoolers includes a fiber configured to irradiate a head of a subject with light, and a holder made of a metal or resin other than rubber. A tip surface of a tip of the fiber that contacts the head of the subject is flat, and a corner of a tip surface of the holder that contacts the head of the subject is chamfered.

A processing subsystem generates perceived images from information bearing nerve impulses that are transmitted from a subject's eye(s) to a visual processing region of the subject's brain along one or more nerves in response to the subject viewing a real-world scene. The processing subsystem generates display images based on the perceived images, and controls a display device to display the display images to the subject. In certain embodiments, the processing subsystem generates the display images by manipulating or modifying the perceived images to include virtual images, and provides a type of virtual pointing on the display images that is used to invoke one or more actions.