Systems and methods are disclosed related to using acoustic waves to detect neural activity in a brain and/or localize the neural activity in the brain. Sensors positioned outside of a skull encasing the brain can detect acoustic waves associated with the neural activity in the brain. From output signals of the sensors, a particular type of neural activity (e.g., a seizure) can be detected. A location of the neural activity can be determined based on outputs of the sensors. In some embodiments, the ultrasound energy can be applied to the location of the neural activity in response to detecting the neural activity.

Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

The disclosure relates to a brain stimulation system (102), comprising: a) a computer program product, e.g. a data carrier, preferably a non-transitory data carrier, or a data stream, comprising program code (P1, P1a) which, when loaded and executed on an electronic control unit (108), provides an operation control system, or b) an electronic control unit (108) with a program code (P1, P1a) loaded on the electronic control unit (108), wherein the program code (P1, P1a), when executed on the electronic control unit (108), provides an operation control system (200), wherein the operation control system (200) is configured to control a brain training and/or stimulation session for a brain, and wherein the operation control system (200) comprises a plurality of control system functionalities, the control system functionalities comprising:

a stimulation functionality (202) which is configured to cause the electronic control unit (108) to issue a stimulation command to an electrical brain stimulation device (122) to cause the electrical brain stimulation device (122) to perform an electrical brain stimulation procedure; and

a presentation functionality (204) which is configured to cause the electronic control unit (108) to issue a presentation command in order to present a task to be performed by a user (120) on a user interface (110), wherein preferably the stimulation functionality (202) and the presentation functionality (204) are linked (254 to 262) or linkable to one another.

Electrodes for use in electroencephalographic recording, including consciousness and seizure monitoring applications, have novel features that speed, facilitate or enforce proper placement of the electrodes, including aligning tabs and arrowed aligning juts, color coding, and an insulating bridge between reference and ground electrodes which ensures a safe application distance between the conductive regions of the two electrodes in the event of cardiac defibrillation or to prevent shorting between the adjacent electrodes by preventing the conductive path to be shared. A method of using a set of four such electrodes is also disclosed.

A mouth guard senses impact forces and determines if the forces exceed an impact threshold. If so, the mouth guard notifies the user of the risk for injury by haptic feedback, vibratory feedback, and/or audible feedback. The mouth guard system may also remotely communicate the status of risk and the potential injury. The mouth guard uses a local memory device to store impact thresholds based on personal biometric information obtained from the user and compares the sensed forces relative to those threshold values. The mouth guard and its electrical components on the printed circuit board are custom manufactured for the user such that the mouth guard provides a comfortable and reliable fit, while ensuring exceptional performance.

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a mental health prediction for a patient. One of the methods includes obtaining brain data captured by one or more sensors characterizing a brain of a patient; determining a network graph from the brain data, wherein: a node of the network graph corresponds to a parcellation in the brain of the patient, and a subset of nodes of the network graph corresponds to a particular functional area of the brain; generating, for each of a plurality of nodes in the network graph, a measure of centrality of the node; generating, for the particular functional area of the brain and using the generated measures of centrality, a health score representing a measure of health of the functional area of the brain; generating a mental health prediction for the patient using the health score.

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a mental health prediction for a patient using a centrality ranking of the brain of the patient. One of the methods includes obtaining brain data of a patient, wherein the brain data comprises, for each of a plurality of pairs of parcellations formed from a set of parcellations where each pair comprises a first parcellation and a second parcellation, data characterizing a number of tracts connecting the first parcellation and the second parcellation; determining a network graph from the brain data; generating, for each of a plurality of nodes in the network graph, a measure of centrality of the node; determining a centrality ranking of the plurality of nodes of the network graph according to the respective measures of centrality; generating a mental health prediction for the patient using the determined centrality ranking.

According to various embodiments, a system may be provided. The system may include: a platform including a plurality of engaging members; a portable device configured to engage with the platform using at least one engaging member of the plurality of engaging members; and a feedback member configured to provide information indicating whether the portable device is engaged with the platform.

One aspect of the invention provides a method including: obtaining neural activity data for a first subject and a second subject during verbal interaction between the first subject and the second subject; and calculating coherence between the neural activity data for the first subject and the neural activity data for the second subject. Another aspect of the invention provides a non-transitory, tangible computer-readable medium comprising computer-readable program instructions for implementing the one or more of the methods described herein.

A test is administered using a device responsive to touch for measuring the saccadic eye movement of an individual that has suffered some sort of trauma (impact or shaking) to the head, and comparing this measurement (post-trauma measurement or post-trauma CQ score) with a previous measurement taken prior to the impact (baseline measurement or baseline CQ score). The comparison yields a value test performance value resulting in a conclusion that the individual may be suffering from a concussion or that the individual is not in a concussive state. The test's accuracy is enhanced by (1) performing periodic baseline readings which are updated as the individual advances with age, (2) the near real-time of the post-trauma measurement in relation to when the trauma occurred, and (3) the automatic determination and transmission of objective test results resulting from a touch screen system which can be transmitted to a networked physician.