Systems, devices, and methods are disclosed which may be used to detect and determine the extent of brain trauma, mental impairment, physical disability, or other brain dysfunction by tracking one or more ocular responses.

To provide a device which can diagnose a brain disease by observing a pupil diameter. A device for diagnosing a brain disease, equipped with a display image control section (3), an imaging section (5) and a judgment section (7), wherein the display image control section (3) can vary a display image displayed on a display section on the basis of a first pattern, the imaging section (5) can take an image of the pupil of a user who watches the display image, and the judgment section (7) can determine whether or not the user is affected with a brain disease using a pattern of the time-dependent change in the size of the pupil of the user which is imaged by the imaging section and the first pattern.

An adaptive cognitive prosthetic that learns to replace neural function that was lost due to a brain injury or disease is described herein. In some embodiments, an adaptive cognitive prosthetic comprises a processing unit for converting input data from an input assembly into a cognitive variable and selecting a stimulation pattern for conveying the cognitive variable. The processing unit employs an adaptive algorithm to assemble the stimulation pattern by combination of subset stimulation patterns, the combination of subset stimulation patterns learned by the adaptive algorithm through error analysis.

In various embodiments, a probe structure is provided. In some embodiments, the probe structure includes a probe body. In some embodiments, the probe structure further includes a plurality of fingers adapted to extend outwards from the probe body. In some embodiments, the probe structure further includes a spring including a plurality of coils adapted to wrap around the probe body and compressed between a compression plane and probe body. In some embodiments, the end coil of the plurality of coils is configured to encircle the plurality of fingers. In some embodiments, the compression plane is a grip held by a human operator. In some embodiments, the compression plane is a robotic end effector that positions itself over any topography.

The present disclosure provides methods for identifying non-penetrating brain injury in a subject, as well as methods for classifying a subject that received a hit to the body that transmitted an impulsive force to the brain as either having a non-penetrating brain injury or not, by analyzing one or more components of frequency-following response (FFR) following administration of an acoustic stimulus to the subject. In addition, the present disclosure provides methods for assessing a subject's recovery from a non-penetrating brain injury. Also disclosed herein are processes and systems for automatically generating acoustic stimuli and processing brain response data to identify non-penetrating brain injuries in subjects.

Devices for localizing an intracerebral hematoma or blood mass in brain tissue. The devices include an elongate probe a color sensors and a light emitter on the distal end of the probe. The color sensors produce a signal corresponding to the color of light reflected into the color sensors. A display is provided to indicate the color detected.

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and/or regulate a temperature of the bodily fluid flowing therethrough.

Disclosed herein is a system that uses an eye tracker for diagnosing and facilitating rehabilitation therapy of a patient suffering from disability. The system creates a human machine interface (HMI) that integrates various low cost biosensors and artificial sensors for conducting rehabilitation therapy. The system combines spinal and supra-spinal feedback of the patient with the operant conditioning to facilitate visuomotor balance therapy (VBT), thereby reducing fall risk in disability survivors. The operant conditioning setup for shaping of visuomotor learning to bring about new behavior or to modify a certain aspect of an existing behavior is used for rehabilitation therapy that includes a behaviour response apparatus, a reward delivery module, a stimulus delivery system, and a behaviour control system. The system can also be extended to the patient's home for providing telerehabilitation therapy.

Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.

A brain activity estimation device includes a brain activity estimation portion. The brain activity estimation portion includes a blood-circulation-amount calculating unit and an estimation unit. The blood-circulation-amount calculating unit is configured to calculate time-series blood-circulation-amount data on a facial surface of a human based on RGB data of photographed image data on the facial surface acquired in time series. The RGB data is obtained by conducting RGB processing on the photographed image data. The RGB processing includes decomposing the photographed image data into three color components composed of an R component, a G component and a B component. The estimation unit is configured to estimate brain activity of the human based on a plurality of decomposition components obtained by decomposing the blood-circulation-amount data by singular value decomposition, principal component analysis, or independent component analysis.