A method (20) and device for deriving an estimate of intracranial blood pressure based on motion data for a wall of an intracranial blood vessel, intracranial blood flow velocity, and a blood pressure signal measured at a location outside the brain. The method is based on identifying (28) a time offset between the two intracranial signals (vessel wall movement and vessel blood flow), and then applying (30) this offset to the blood pressure signal acquired from outside the brain to obtain a fourth signal, indicative of estimated intracranial blood pressure.

A psychological condition estimation system includes an acquisition unit and an estimation unit. The acquisition unit acquires information about respective activity levels of a plurality of sensory areas of a subject's brain. The estimation unit estimates a sense, which is highly related to the subject's psychological condition, out of a plurality of types of senses corresponding respectively to the plurality of sensory areas, based on the information, acquired by the acquisition unit, about the activity levels of the plurality of sensory areas when the subject is exposed to multiple types of stimuli.

A mouth guard senses impact forces and determines if the forces exceed an impact threshold. If so, the mouth guard notifies the user of the risk for injury by haptic feedback, vibratory feedback, and/or audible feedback. The mouth guard system may also remotely communicate the status of risk and the potential injury. The mouth guard uses a local memory device to store impact thresholds based on personal biometric information obtained from the user and compares the sensed forces relative to those threshold values. The mouth guard and its electrical components on the printed circuit board are custom manufactured for the user such that the mouth guard provides a comfortable and reliable fit, while ensuring exceptional performance.

An aspect of the present invention is a consciousness disorder mitigation apparatus, including: a first estimation unit configured to estimate body fluid volume information, the body fluid volume information being information on a body fluid volume present in a head of a user; a second estimation unit configured to estimate oxygen supply volume information, the oxygen supply volume information being information on an oxygen supply volume representing an amount of oxygen in a brain of the user; a pressurization unit configured to be attached to the user and to apply a pressure corresponding to an estimation result of the first estimation unit and an estimation result of the second estimation unit; and an oxygen supply unit configured to supply oxygen to the user based on the estimation result of the second estimation unit.

A system for measuring a membrane potential is disclosed. The system comprises a photoacoustic probe including a laser and an ultrasound transducer. The laser is configured to emit a light signal at one or more wavelengths to a neuronal cell. The neuronal cell may comprise a voltage-sensitive protein configured to absorb the light signal in a voltage-dependent manner. The ultrasound transducer is configured to receive a photoacoustic signal from the voltage-sensitive protein in response to absorbing the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer and calculate a membrane potential of the neuron based on the photoacoustic signal. Methods of measuring a membrane potential and biomaterials related to the voltage-sensitive protein are also disclosed herein.

Systems, processes and devices for real-time brain monitoring to generate and control an interface of a display device with a visual representation of a Brain Value Index for entropy, a connectivity map and treatment guidance. Systems, processes and devices for real-time brain monitoring capture sensor data, process the data and dynamically update the interface in real-time.

Conventionally, the arterial input function is determined by administering a contrast agent and measuring the responsive magnetic signal in a reference voxel located in a large artery such as the middle cerebral artery. By instead measuring the signal in a voxel of the choroid plexus, a more accurate profile for the arterial input function may be obtained. The metabolic activity in the choroid plexus is negligible, which provides greater certainty for signal sampling.

A magnetic resonance pulse sequence technique may acquire a water reference spectrum and two water suppressed metabolite spectra and with frequency selective inversion pulse centered at either single frequency, at multiple frequencies, or in a single acquisition. Subtraction of the inverted from non-inverted water suppressed metabolite spectrum results in single or a combination of specific metabolite peak/peaks alone with a flat baseline for easier quantification.

Techniques are described for determining cognitive impairment, an example of which includes accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events; processing the set of epochs to identify parameter values one or more of which is based on information from the individual epochs without averaging or otherwise collapsing the epoch data. The parameter values are input into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired.

Disclosed are a medical device apparatus, system, and method. A method includes receiving biometric information, by an external device external to a body of a user, of the user from an internal device within the body of the user, and wirelessly transmitting stimulus information configured to specify a stimulus based on the biometric information, and power to the internal device configured to drive the internal device and to apply the stimulus in response to the transmitted stimulus information. A method also includes wirelessly transmitting, from an internal device in a body of a user, biometric information of the user to an external device located outside the body of the user, and wirelessly receiving from the external device stimulus information configured to specify a stimulus, and power configured to drive the internal device and to apply the stimulus to the user in response to the received stimulus information.