An electrode for neural sensing and stimulation comprising a first electrode disposed on a probe and a second electrode disposed on the probe, wherein a voltage or impedance is sensed using the first electrode and second electrode.

Provided is a technique for comprehensively understanding the relationship between brain regions. A brain connectivity analysis system herein includes a memory configured to have stored therein a connectivity analysis program for analyzing the connectivity; and a processor configured to read the connectivity analysis program from the memory and analyze the connectivity. The processor is configured to execute a process of acquiring from a storage unit measured data on a plurality of selected regions of a brain, a process of determining at least two of the plurality of regions as seed regions and calculating a plurality of connectivity features for the seed regions and other regions from the measured data on the plurality of regions, and a process of generating a connectivity feature graph showing a relationship between a transfer delay time and another connectivity feature of each region that are included in the plurality of connectivity features.

An exemplary system, method and computer-accessible medium for determining an effect(s) of a convulsive stimulation therapy(ies) on a patient(s) can be provided, which can include, for example, receiving first information related to a visual network or a default mode network of a brain of the patient(s), receiving second information related to a subgenual ACC or a default mode (DMN network of the brain of the patient(s), and determining the effect(s) of the convulsive stimulation therapy(ies) based on a relationship between the first information and the second information. The convulsive stimulation therapy(ies) can be an electroconvulsive therapy or a magnetic seizure therapy.

There are provided an information output apparatus, an information output method, and an information output program capable of outputting information effective for diagnosis or evaluation of dementia. In a case where a brain area having a high atrophy rate is input, the information output apparatus can output a test item highly relevant to the input brain area using a first table T1 that stores the relevance between a plurality of divided brain areas of a brain image and a plurality of test items of a dementia diagnostic test. In addition, in a case where a test item of interest is input, a brain area highly relevant to the input test item can be output.

Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states.

Systems, methods, and computer-readable media are described for predicting a neurological injury to a participant in an activity. The activity can be, for example, an athletic activity that involves repeated, high-impact collisions between participants. Sensor data reflecting interactions between participants in the activity is received from various wearable and non-wearable sensors. The sensor data is evaluated in conjunction with a baseline neurological risk profile of a participant to determine a likelihood that the participant has suffered a potential neurological injury. If this likelihood meets a threshold risk level, an onsite request/response test is initiated to glean more information relating to the participant's condition. Response data associated with the onsite test is cognitively evaluated to determine an updated likelihood of neurological injury to the participant and a follow-up action is determined based on the updated likelihood of neurological injury.

The present invention discloses indicator fluids, reference indicator fluid, and usage thereof, and systems and methods for assessing movement of molecular substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a human cranio-spinal cavity. Indicator fluid moving from the cerebrospinal fluid compartment enables measurements of levels of indicator fluid in blood or urine and assessment of the cranio-spinal cavity's ability to remove molecular substances. The indicator fluids may be contrast agents used for imaging, such as by computed tomography imaging, and magnetic resonance imaging, or imaging utilizing radioactive substances by positron emission tomography, single-photon emission computed tomography or scintigraphy. Using these imaging modalities, the invention describes indicator fluids, systems and methods enabling assessment of movement of substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a cranio-spinal cavity, and from the human cranio-spinal cavity to lymphatic pathways or kidneys.

An illustrative system may include a component configured to be worn on a body of a user, the component comprising a time-to-digital converter (TDC) configured to: receive, during a predetermined event detection time window that commences in response to an application of a light pulse to a target within the body, a signal triggered by an event in which a photodetector detects a photon of the light pulse after the light pulse reflects from the target; and measure, based on the receiving the signal, a time interval between when the event occurred and an end of the predetermined event detection time window. The system may further include a processor configured to determine, based on the time interval and the predetermined event detection time window, an arrival time of the photon at the photodetector.

An exemplary controller may include a single clock source configured to generate a single clock signal used to drive one or more components within a plurality of magnetometers and a plurality of differential signal measurement circuits configured to measure current output by a photodetector of each of the plurality of magnetometers.

A mental impairment detection system and non-invasive method of detecting mental impairment of a user are provided. A test (e.g., an inhibitory reflex test or a sustained attention test) is administered to the user, brain activity in a frontal lobe of the user is non-invasively detected while the test is administered to the user, and a level of mental impairment of the user is determined based on the brain activity detected in the frontal lobe of the user.