An exercise therapy video game and monitor system for physical targeted activation and cognitive skills for learning fluency of an individual. More specifically, the system includes a whole-body fitness program that integrates motion, motor-sensory learning, and vision using games and motion sensing technology to track video-directed body position and movements of the individual. The system includes at least a first gaming platform, interactive exercise software to provide movement instructions to the individual, a computing system, and one or more sensors, such as motion sensors or sensors associated with a mat, to track body positions and movements of the individual. The system can then provide instant feedback to improve the body positions and movements of the individual to better replicate video directions.

Embodiments may provide techniques that may provide the capability to provide brain monitoring and stimulation devices using an array of multifunctional cells of circuitry. For example, in an embodiment, an apparatus may comprise a plurality of multifunction pixels, each multifunction pixel may comprise electrical reading enabling circuitry, electrical stimulation enabling circuitry, optical reading enabling circuitry, optical stimulation enabling circuitry, and data selection circuitry.

The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction or associated cranial nucleus or supranuclear input, useful for detecting, diagnosing or screening for increased intracranial pressure, or useful for detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure by tracking eye movement of the subject. The methods may be performed by a) analyzing eye movement of the subject; b) comparing eye movement of the subject to eye movement of a control or the subject's own baseline eye movement; and c) identifying the subject as having eye movement significantly different from the control or the subject's own baseline eye movement.

Provided are systems, methods, and devices for providing mediation of a traumatic brain injury. Systems may include an interface, processing devices, and a controller. The interface is configured to obtain measurements from a brain of a user with a traumatic brain injury. A first processing device is configured to generate multiple brain state parameters characterizing one or more features of a brain state of the user. A second processing device is configured to generate models of the brain of the user based on the plurality of brain state parameters and the plurality of measurements, and determine, using the models and training data comprising one or more mediation data points, a mediation procedure for reducing one or more symptoms of the traumatic brain injury. The mediation procedure is provided to one or more entities, and one or more control signals are generated by the controller based on the mediation procedure.

A method of monitoring a subject includes detecting subject head motion via a microelectromechanical systems (MEMS) sensor associated with a device worn by the subject, such as a device worn on a region of the head or a headset attached to an ear. The head motion information from the MEMS sensor is processed to determine subject head displacement relative to an origin and/or to identify footstep information, and the processed head motion information is transmitted to a remote device. Processing the head motion information from the MEMS sensor may be performed via at least one processor associated with the device worn by the subject and/or via a second device in telemetric communication with the MEMS sensor. The method may include processing head motion information from the MEMS sensor to determine if the subject has fallen down and/or is not moving.

A method for selecting a seed region for use in a seed-based cortical functional mapping method includes providing at least one RSN map of at least one subject, each of the at least one RSN maps comprising a plurality of functional voxels within a brain of each of the at least one subjects, each functional voxel of the plurality of functional voxels associated with a probability of membership in an RSN. A subset of the functional voxels characterizing a contiguous region is selected as the seed region, each functional voxel of the seed region having a probability of membership in the RSN above a threshold value.

Aspects of the disclosure relate to pledget stimulation/recording electrode assemblies that are particularly useful for automatic periodic stimulation. Embodiments are compatible with nerve monitoring systems to provide continuous stimulation of a nerve during surgery. Disclosed embodiments include an electrode assembly having one or more electrodes rotatably supported by and positioned within a pledget substrate. The flexible pledget substrate conforms and fixates to bioelectric tissue to secure the electrode assembly in position, wrapped around the target tissue. In some embodiments, the pledget substrate includes two bodies, each including at least one electrode, the two bodies being selectively separable so that the bodies can be repositioned with respect to one another. The electrode assembly further includes a lead wire assembly including at least one insulating jacket positioned around a wire core. Optionally, the electrode assembly includes an insulating cup interconnecting the electrode and the insulating jacket.

A biological measurement device includes a light emitting device, a sensor, and a processing circuit. The light emitting device irradiates a first region and a second region, which is located on an upper side relative to the first region, of a forehead of a subject with light. The sensor detects first scattering light generated by the light incident on the first region and second scattering light generated by the light incident on the second region and outputs detection signals according to intensities of the first and second scattering light. The processing circuit selects one of the first and second regions as a target region based on the detection signals and/or an image signal indicative of an image including a face of the subject and generates and outputs brain activity data indicative of a state of brain activity of the subject based on the detection signal in the selected target region.

The present invention provides a magnetic monitoring system for imaging, monitoring, scanning or mapping for brain or heart activity of subjects including children and adults, the system comprising of a magnetoencephalographic or magnetocardiographic system incorporating SQUID sensors for measuring brain activity or heart activity, the system including a plurality of Dewar helmets of variable sizes and shapes; and a plurality of monitoring interfaces; wherein the sensor system helmet is moveable by horizontal Dewar rotation. The sensor system includes configurations where the size and shape of helmets in the system may be different to accommodate different sized subjects for monitoring simultaneously.

A method and device are for generating and displaying a map of a brain operating field, brain tissue areas associated with a stimulated brain function being marked in the map. In the method, during a measurement cycle a stimulation of a brain function is effected and a stimulation image of the brain operating field with the stimulated brain function is recorded, a reference image without the stimulated brain function is recorded, the stimulation image and the reference image are used to generate the map, and the map is displayed on a display. A plurality of cycles are performed. A new map is generated after each cycle following the first cycle. In order to generate the new map, the stimulation and reference images of one or more preceding cycles are used besides the images recorded in the cycle just carried out. At least the new map is displayed after each cycle.