Source light having a range of optical wavelengths is generated. The source light is split into sample light and reference light. The sample light is delivered into a sample, such that it is scattered by the sample, resulting in signal light that exits the sample. The signal light and reference light are combined into an interference light pattern having optical modes. Different subsets of the optical modes of the interference light pattern are respectively detected, and high-bandwidth analog signals respectively corresponding to the different subsets of optical modes of the interference light pattern are output. At least one characteristic is extracted from each of the plurality of high-bandwidth analog signals, and low-bandwidth digital signals respectively comprising the extracted characteristics are output. The sample is analyzed based on the low-bandwidth digital signals.

In some examples, an apparatus may include a laser, a source fiber that delivers the laser radiation to an object, and a detector fiber that receives scattered laser radiation and illuminates a detector array with the scattered laser radiation to form speckles on the detector array. In some examples, the object may be directed illuminated by a laser. The detector array may include a plurality of detectors, and may be positioned to receive the scattered laser radiation from the end of the detector fiber. The distance between the detector array and the end of the detector fiber may be adjustable. A controller may be configured to receive detector data from the detector array, determine a time-dependent intensity autocorrelation function for each detector of a plurality of detectors, and determine an ensemble average autocorrelation function. The apparatus may provide information relating to dynamic processes within the object. Various other methods, systems, and computer-readable media are also disclosed.

A lead body is operable to be implanted proximate a target nerve tissue of a patient. A sensing electrode is configured to sense biopotentials over a first partial circumference of the lead body. A stimulation electrode is configured to deliver stimulation energy over a second partial circumference of the lead body. A signal generator is electrically coupled to the stimulation electrode and a sensing circuit is coupled to the sensing electrode. A processor is operable to apply a stimulation signal to the stimulation electrode via the signal generator and, via the sensing circuit, sense an evoked response to the stimulation signal that propagates along a neural pathway.

Disclosed is a system and method for segmentation of selected data. In various embodiments, automatic segmentation of fiber tracts in an image data may be performed. The automatic segmentation may allow for identification of specific fiber tracts in an image.

A system and a method for mapping brain tissue damage from quantitative imaging data. The method is implemented by acquiring a quantitative map of a brain tissue parameter of said brain; acquiring a tractography map for said brain; superimposing a first map based on the quantitative map onto a second map based on the tractography map. Metrics are extracted from the superimposition that reflect a distribution of tract-specific quantitative values of the brain tissue parameter and the metrics of the brain are displayed.

A method for quantifying a content of hydrophobic components contained in a liquid using a contact area diffusion factor (CADF) of a droplet of the liquid to a solid surface is provided. In addition, the obtained content of the hydrophobic components provides information about prediction for possibility of developing a metabolic disease or dementia, or information about the incidence or progression of a metabolic disease or dementia.

In one embodiment, an implantable pulse generator (IPG) for providing a neurostimulation therapy, comprises: pulse generation circuitry and pulse delivery circuitry for controlling generation and delivery of electrical pulses to a patient using one or more electrodes of a stimulation lead; measurement circuitry for determining characteristics of one or more electrodes selected for delivery of electrical pulses; and a processor for controlling the IPG according to executable code; wherein the IPG is adapted to calculate values for an impedance model of the one or more selected electrodes using the determined plurality of voltage measurements and to adjust current levels for the exponentially decreasing current pattern based on the calculated values for the impedance mode.

Systems and methods configured for simultaneous imaging and stimulation using a microscope system. The microscope system can have a relatively small size compared to an average microscope system. The microscope can comprise in part an imaging light source and a stimulation light source. Light from the imaging light source and the stimulation light source can be spectrally separated to reduce cross talk between the stimulation light and the imaging light.

A method for monitoring autoregulation includes, using a processor, using a processor to execute one or more routines on a memory. The one or more routines include receiving one or more physiological signals from a patient, determining a correlation-based measure indicative of the patient's autoregulation based on the one or more physiological signals, and generating an autoregulation profile of the patient based on autoregulation index values of the correlation-based measure. The autoregulation profile includes the autoregulation index values sorted into bins corresponding to different blood pressure ranges. The one or more routines also include designating a blood pressure range encompassing one or more of the bins as a blood pressure safe zone indicative of intact regulation and providing a signal to a display to display the autoregulation profile and a first indicator of the blood pressure safe zone.

Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.