A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

Many embodiments of the invention include systems and methods for evaluating motion from a video, the method includes identifying a target individual in a set of one or more frames in a video, analyzing the set of frames to determine a set of pose parameters, generating a 3D body mesh based on the pose parameters, identifying joint positions for the target individual in the set of frames based on the generated 3D body mesh, predicting a motion evaluation score based on the identified join positions, providing an output based on the motion evaluation score.

Disclosed is a portable monitoring module and a monitoring method utilizing the module for monitoring a plurality of electrical biosignals of a person. The module includes a measurement for measuring an electrical biosignal from the at least two electrodes, a wireless communication unit, and a processing unit. The processing unit selects a biosignal type to be monitored from a list of types supported by the monitoring module, store samples of biosignal data generated by the measurement unit, detect an indicator pattern within the biosignal data, wherein the indicator pattern represents an indication of a possible event of the selected biosignal type, and send a set of biosignal data wirelessly to a validation system. The set of biosignal data represents a sequence of samples of biosignal data related to the detected indicator pattern, and the validation system confirms the presence of the event in the received set of biosignal data.

Methods for preventing or treating motor-related neurological conditions include using ocular light therapy in connection with a conventional therapy for a motor-related neurological condition, such as a drug regimen, to adjust levels of melatonin and/or dopamine in the body of a subject. The ocular light therapy may include elevated levels of blue-green light or green light (e.g., light within a wavelength range of 460 nm to 570 nm, 490 nm to 570 nm, about 520 nm to 570 nm, etc.). The ocular light therapy may also include reduced levels of amber, orange and/or red light. Methods for diagnosing motor-related neurological conditions include ocular administration of increased amounts of amber, orange and/or red light to cause a subject to temporarily exhibit one or more symptoms of any motor-related neurological condition to which the subject is predisposed, or which the subject may already be experiencing.

The present invention relates to a neural implant comprising a biomaterial having an outer surface with a stochastic nanoroughness (Rq), and the application of said stochastic nanoroughness in the diagnosis and/or treatment of a neurological disorder, such as, for example, Parkinson's disease, Alzheimer's disease, glioblastoma and/or for disrupting, and/or preventing glial scars in the context of mammalian mechanosensing ion channels selected from the family of PIEZO-1 and PIEZO-2 ion channels.

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

The present specification describes a system for diagnosing or screening one or more pathologies in a patient. The system includes a headset with at least one microphone or accelerometer to passively receive vibrations generated by the cerebral vasculature of the patient's brain, computing devices coupled with the headset for processing the received vibrations to obtain a unique signal, and a signal analyzer to analyze the signal in order to determine if the data includes patterns uniquely indicative of at least one of tension headaches, migraines, depression, dementia, Alzheimer's disease, epilepsy, Parkinson's disease, autism, cerebral vasospasm and meningitis.

A system for neuromodulation or neurostimulation comprising at least one sensing unit configured to provide a sensor signal correlating with a physiological value describing neurological function or dysfunction of a patient, at least one control unit, at least one stimulation unit, and at least one of at least one Central Nervous System stimulation module for providing Central Nervous System stimulation or at least one Peripheral Nervous System stimulation module for providing Peripheral Nervous System stimulation, wherein the control unit is configured to detect the neurological dysfunction based on the sensor signal and to trigger the neuromodulation or neurostimulation. The disclosure further relates to a method for providing neuromodulation or neurostimulation and the use of a neuromodulation system in the method for the treatment of a patient.

System and methods for identifying a brain condition of a patient subject to a plurality of disease states are provided, in some aspects, the method includes receiving imaging data associated with a patient's brain acquired using an imaging system, and constructing a classifier having signatures corresponding to a plurality of disease states. The method also includes applying the classifier to the imaging data to determine a degree to which the patient expresses at least one of the plurality of disease states, and determining a brain condition of the patient using the determined degree. The method further includes generating a report indicative of the brain condition of the patient.

A portable device (1) for quantifying movements of pronation and/or supination of a person, and intended to be used when the person has the elbow on a horizontal support, comprising: a solid armature (2) with: means for attaching (4), configured to secure one hand of the person in the device (1); a central pivot element (5) intended to be in contact with the horizontal support, during the angular oscillations of the hand, between two opposed identical “first block angles” relative to a vertical position called “neutral position”, the “first block angles” defining a “small amplitude”, first means for blocking (8) the movement of pronation and the movement of supination of the elbow, at the two “first block angles”; second means for blocking (9) the movement of pronation and the movement of supination, at two identical opposed “second block angles” relative to the neutral position, between the solid armature (2) relative to the horizontal support, the “second block angles” defining a “large amplitude” greater than the “small amplitude”; an IMU (3) able to measure movement data.