A multimodal wearable band uses mechanical vibrations to stimulate sensory neurons in the wrist or ankle to reduce the severity of tremors, rigidity, involuntary muscle contractions, and bradykinesia caused by neurological movement disorders and to free users from freezing induced by movement disorders. The device uses sensors to provide output used by a processing unit to determine a stimulation pattern for the user and to determine when stimulation is necessary, and then uses one or more transducers to correspondingly stimulate the user’s neurological pathways to lessen the severity of the user’s symptoms. The device can also be adapted to integrate with third party devices.

In some embodiments, a display system comprising a head-mountable, augmented reality display is configured to perform a neurological analysis and to provide a perception aid based on an environmental trigger associated with the neurological condition. Performing the neurological analysis may include determining a reaction to a stimulus by receiving data from the one or more inwardly-directed sensors; and identifying a neurological condition associated with the reaction. In some embodiments, the perception aid may include a reminder, an alert, or virtual content that changes a property, e.g. a color, of a real object. The augmented reality display may be configured to display virtual content by outputting light with variable wavefront divergence, and to provide an accommodation-vergence mismatch of less than 0.5 diopters, including less than 0.25 diopters.

Devices, systems, and techniques for analyzing video information to objectively identify patient behavior are disclosed. A system may analyze obtained video information of patient motion during a period of time to track one or more anatomical regions through a plurality of frames of the video information and calculate one or more movement parameters of the one or more anatomical regions. The system may also compare the one or more movement parameters to respective criteria for each of a plurality of predetermined patient behaviors and identify the patient behaviors that occurred during the period of time. In some examples, a device may control therapy delivery according to the identified patient behaviors and/or sensed parameters previously calibrated based on the identified patient behaviors.

The present invention discloses indicator fluids, reference indicator fluid, and usage thereof, and systems and methods for assessing movement of molecular substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a human cranio-spinal cavity. Indicator fluid moving from the cerebrospinal fluid compartment enables measurements of levels of indicator fluid in blood or urine and assessment of the cranio-spinal cavity's ability to remove molecular substances. The indicator fluids may be contrast agents used for imaging, such as by computed tomography imaging, and magnetic resonance imaging, or imaging utilizing radioactive substances by positron emission tomography, single-photon emission computed tomography or scintigraphy. Using these imaging modalities, the invention describes indicator fluids, systems and methods enabling assessment of movement of substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a cranio-spinal cavity, and from the human cranio-spinal cavity to lymphatic pathways or kidneys.

A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

Systems, methods, and computer program products are provided for determining one or more biomarker and/or health condition of a target patient. In various embodiments, a method is provided where a plurality of health data of the target patient and/or a plurality of first order features determined from the plurality of health data of the target patient are received as input to a pre-trained artificial neural network. The plurality of health data is derived from a plurality of modalities. A plurality of latent variables based on the plurality of health data and plurality of first order features are received from an intermediate layer of the pre-trained artificial neural network. The plurality of latent variables are provided to a pre-trained learning system. The pre-trained learning system is trained to receive as input the plurality of latent variables and output one or more biomarker and/or health condition of the target patient.

A system, method and apparatus for diagnosis and therapy. Preferably, the system, method and apparatus is provided for diagnosis and therapy of neurological and/or neuromuscular deficits by using a computational device. Optionally and preferably, the system, method and apparatus track one or more physical movements of the user, which are then analyzed to determine whether the user has one or more neurological and/or neuromuscular deficits. Additionally or alternatively, the system, method and apparatus induce the user to perform one or more physical movements, whether to diagnose such one or more neurological and/or neuromuscular deficits, to treat such one or more neurological and/or neuromuscular deficits, or a combination thereof.

Systems and methods for non-invasive and/or non-contact measurement of a subject's tremor in the context of therapeutic intervention is presented. The system includes a memory, a communications interface, a sensor to measure a signal associated with position or motion of an extremity of the subject, and a processor. The processor is configured to receive the signal from the sensor. The processor is further configured to communicate, via the communications interface, the signal, login credentials, and position or motion data to a remote server coupled to a remote electronic health record database. The remote server is configured to receive the signal from the sensor. The processor is configured to receive an analysis that quantified the severity of tremor.

The present disclosure describes a measurement unit including measurement electronics, a wireless transceiver unit, and a processing. The measurement electronics are configured to measure an EMG signal and a motion signal from a limb of a person. The processing unit is configured to determine a principal component representation of the EMG signal and the motion signal in real time, wherein the principal component representation represents a projection of at least one feature of the EMG signal and at least one feature of the motion signal into at least one uncorrelated feature in a feature space formed by orthogonal basis vectors, and transmit the principal component representation to an external system with the wireless transceiver unit.

A service to coordinate the care of patients who are on a REMS-required medication. The service implements a monitoring hub for coordinating the work between a clinician, pharmacy, and laboratory in the care of a patient. The patient has blood samples tested for safety monitoring. The monitoring hub performs the task of entering the test results . . . into the REMS database. The monitoring hub has qualified personnel who are enrolled in the REMS program as a prescriber designee for the clinician. The prescriber designee works with the clinician, pharmacy, or laboratory to ensure compliance with the REMS requirements. In addition to providing administrative support for REMS compliance, the service could be an integrated care management system that assists patients/families and providers with other aspects of their care and practice needs.