A method and user device for determining a unified Parkinson's disease rating scale (UPDRS) value associated with a user of the user device include obtaining video data associated with a movement of a body part of the user. The UPDRS value is determined using a model and the video data associated with the movement of the body part of the user. The UPDRS value is provided to permit an evaluation of the user based on the UPDRS value.

Provided are systems, methods, and kits for multifunctional smell assessment. The kits may comprise a first surface adhered by a first releasable adhesive comprising an odorous volatile compound; and the system for registering if the odorous volatile compound is detected by a user. The system or method may comprise queries for obtaining a first input on whether the user detects and identifies the odorous volatile compound, and an intensity by which the odor is perceived.

Systems and methods for deep brain stimulation using kinematic feedback in accordance with embodiments of the invention are illustrated. One embodiment includes a deep brain stimulation system, including an implantable neurostimulator, a first inertial measurement unit (IMU), a second IMU, and a controller, where the controller is communicatively coupled to the implantable neurostimulator, the first IMU, and the second IMU, and where the controller is configured to obtain kinematic data from the first IMU and the second IMU, identify an abnormal movement event based on the kinematic data, and modify deep brain stimulation provided by the implantable neurostimulator based on the identified abnormal movement event.

Provided is a device comprising a sensor to detect deviation of muscle position in a user. The device includes a first housing portion having at least one sensor and at least one signaling mechanism to alert a user and a second housing portion rotatably coupled to the first housing portion. The second housing portion has an attachment element to maintain the device on the user. The sensitivity of the device can be configured to respond to incorrect muscle position and the sensitivity of the device can be calibrated through rotating the first housing portion with respect to the second housing portion.

A wireless deep brain stimulation method and device.

Provided herein are a method of detecting neurological impairment and a device for testing sensorimotor control to detect neurological impairment. The method includes positioning a head-mounted display on the user's head, the head-mounted display placing the user in a virtual or augmented reality environment; presenting the subject with a software-generated object in the virtual or augmented reality environment; providing instructions directing the user to execute one or more sensorimotor activities relating to the software-generated object within the virtual or augmented reality environment; recording data during execution of the one or more objectives; and determining if there is a neurological impairment based upon the recorded data. The device includes a head-mounted display, one or more processors, and one or more hardware storage devices having stored thereon computer-executable instructions which are executable by the one or more processors to display a virtual immersive environment in the head-mounted display.

This invention relates to disease detection by imaging and treatment of virus infection. Previously, there was no way to use CEST MRI imaging to early detect and map the neurodegenerative diseases, multiple sclerosis disease, concussion, and traumatic brain injury. Also, previously, there was no way to use Computed Tomography (CT) imaging to early detect and map the neurodegenerative diseases. Embodiments of the present invention use a non-invasive CEST MRI imaging method is disclosed for early detection of diseases by using MRI or by using CT. The endogenous (MRI) contrast of the biological tissue can rely on the endogenous protons of the proteins and peptides as a source of the contrast, such as hydroxyl, amine, and amide protons, and thereby provide imaging and mapping for the early detection of the neurodegenerative diseases, multiple sclerosis disease, concussion, traumatic brain injury, and other diseases by using endogenous protons contrast via CEST MRI. Also, the exogenous agents can be used to produce MRI contrast, such as agents contain exchangeable protons and thereby provide imaging and mapping the inflammation in cancer and the expressed proteins in cancer cells for cancer detection. Also, using exogenous CT contrast agents for detection of amyloid beta, tau protein, alpha-synuclein protein, and aggregation proteins in neurodegenerative diseases and inflammation in many diseases such as neurodegenerative diseases, cancer and other inflammatory diseases Also, this invention relates to novel methods of treatment virus infection and enhance the immune system to produce antibodies against the viruses.

There is included an apparatus and system including image segmentation code, configured to cause at least one hardware processor to segment an image of a person's hand from an input image, and classification code configured to cause the at least one processor to classify the segmented image of the person's hand according to at least one predefined pose.

Systems and methods are provided for treating a condition associated with a Parkinson's disease (PD) subject, for example for treating or ameliorating motor and/or nonmotor symptoms or disorders in Parkinson's disease patients. An example system may include a sleep sensing circuitry and a drug dispensing device. The sleep sensing circuitry may be used to detect a sleep pattern of a PD patient, and the drug dispensing device may be used to continuously deliver a therapeutically effective compound to the PD patient based on the sleep pattern. Operational parameters of the drug delivery device (e.g., drug delivery flow rate and drug delivery timing) may be pre-programmed prior to bedtime and/or be adjusted in real time, for example during sleep, based on the detected sleep pattern to treat a condition associated with the PD subject, for example to optimize sleep, improve sleep quality, ameliorate non-motor disorders in the treated PD patient, etc.

Described are methods, devices, and systems for a novel, inexpensive, easy to use therapy for providing treatment to the brain. Described are methods and devices to provide treatment to the brain that involves no medication. Methods and devices described herein use alternating magnetic fields to provide treatment to the brain.