Disclosed are methods for quantification of a perivascular space in a subject's central nervous system. The methods include administering contrast agent into cerebrospinal fluid of the subject; performing quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI) on a region of interest of the subject's brain; and determining presence of the contrast agent in the perivascular space within the region of interest.

Disclosed herein are systems and methods for treating memory impairment, and more specifically to customized visual presentation for treating memory-related disorders and diseases. The disclosed systems and methods can predict clinical status of patients based on platform user behavior, such as those of patients. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The present disclosure discloses system and method for detecting behavioral disorder of a person in early stage. The claimed system including: a plurality of camera modules for capturing videos of the person, wherein the captured videos are utilized to observe behavior of the person; a processing unit connected with the plurality of camera modules to pre-process the captured videos for generating behavioral disorder report of the person; a motion detection sensor connected with the processing unit for detecting motion of the person from the captured videos; an extractor connected with the motion detection sensor for extracting features from the captured videos; and a classifier connected with the extractor to differentiate abnormal behavior from normal behavior of the person.

An interactive multi-purpose interactive cognitive platform is provided that uses image-based interactivities and may use enriched visual stimuli for diagnoses, treatment, and to evaluate and assess the progress and/or treatment of cognitive diseases and/or conditions with cognitive impacts. The platform may be used for performance enhancement training. The platform may include a graphical user interface. The platform is designed to cooperatively engage multiple cognitive domains using interactivities-embedded assessments. The images and image sets may involve the application of Gestalt principles for assessments and may be personalized address individual user preferences. The multi-purpose interactive cognitive platform may be used to produce diagnostics and/or treatment plans for specific cognitive conditions and diseases with a cognitive component. The multi-purpose interactive cognitive platform may be used for gaming, stress reduction, mindfulness, skills development, training, and/or performance enhancement for those without cognitive problems and/or for those interested in maintaining their cognitive health.

A communicating device for placing within a blood vessel. The communicating device has a proximal end part, a terminal end part and a wired connector that communicatively connects the proximal end part with the terminal end part. The proximal end part has a battery connected to a wireless charging terminal and a signal processing circuit connected to a wireless communication terminal. The terminal end part has a plurality of sensors, electrodes and microfilaments to be deployed through the walls of the vessel.

A method and system for remote diagnosis of a cognitive disorder in humans are provided. The system comprises receive, over a network, at least one facial image of a patient; extracting, from the at least one facial image, at least one facial feature indicative of a cognitive decline; classifying the at least one extracted facial feature using a classifier, wherein the classifier maps a plurality of candidate facial features to a score indicating a stage of a cognitive decline; and determining a positive diagnosis of a cognitive decline of the patient, based on the score provided by the classifier in response to the at least one extracted facial feature.

A system for measuring neuromotor disorders from speech is configured to receive an audio recording that includes spoken speech and compute feature coefficients from at least a portion of the spoken speech in the audio recording. The feature coefficients represent at least one characteristic of the spoken speech in the audio recording. One or more vocal tract variables may be computed from the feature coefficients. The vocal tract variables may represent a physical configuration of a vocal tract associated with at least one of the one or more sounds. The vocal tract variables and/or the feature coefficients are used to determine if a disorder that affects neuromotor speech is present.

The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for evaluating the efficacy of neuromodulation therapy using evoked potential (EPs). The systems and methods disclosed herein facilitate the evaluation of both parameter-dependent and system-dependent changes in EPs as indicators of therapeutic efficacy.

A patient therapy method and program product are provided for communicating with a patient monitor to obtain data from a patient engaged in physical therapy. A library of musical features includes a plurality of coordinated musical tracks associated with respective functional therapeutic outcomes. The functional therapeutic outcomes include gait characteristics comprising at least at strike, cadence, stride length deviations. Based on a selected functional therapeutic outcome, musical tracks are selected and mixed together at a desired tempo. The tracks are adjusted based on changes in patient data.

The present invention provides objective methods of diagnosis and behavioural treatments of neurological disorders such as autism spectral disorders and Parkinson's disease.