A driver condition estimating device includes circuitry configured to measure movement of the head of a driver from output of a driver camera and detect a sign of abnormality of the driver from the movement of the head. On condition that lateral acceleration acting on the head of the driver is a predetermined value or less, the circuitry is configured to calculate a periodic feature amount from time series data showing the movement of the head of the driver, calculate a time series variation pattern from the obtained periodic feature amount, and compare of the obtained time series variation pattern with a predetermined threshold.

Implantable nerve transducers are provided herein, along with methods of fabricated such implantable nerve transducers. In one embodiment, an implantable nerve transducer includes a first housing including a first material, the first housing defining a first chamber; a stimulator circuit positioned within the first chamber and being disposed on a first substrate including the first material, the first material being a non-metallic biocompatible material; a second housing including the first material, the second housing defining a second chamber; and a solid-state battery disposed on a second substrate including the first material, the solid-state battery being positioned within the second chamber, the second housing being mounted to the first housing, the implantable nerve transducer being configured to be implantable and configured to stimulate or sense signals from a nerve of a living organism.

A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

An apparatus and method for determining the hemispheric emotional valance of a person is disclosed. The apparatus assists in the selection of appropriate treatment modalities for various neurological disorders. A computer outputs a series of preselected stimuli and a screen is adapted to display the preselected stimuli to the person. The stimuli may comprise a focal point presented on the screen for the person to fixate on and a picture. The focal point is positioned on the screen so that the images will be seen in the person's lateral visual field. The focal point and the picture are displayed to the person for a preselected period of time to induce stress or comfort as the mental state associated with one of the cerebral hemispheres by stimulating the contralateral hemisphere. The level of reaction to the stimuli is recorded in the computer or manually.

The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.

A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.

The movement of a part of human body, e.g. a limb, is monitored. The movement includes N iterated rotations in a plane. A sensing device is fixed to the limb and provides data indicative of the limb movement. These data are processed to generate a rotation signal. Then, portions of the rotation signal corresponding to each movement iteration are identified. To this purpose, a plurality of null-velocity instants is identified, wherein the angular velocity of the sensing device is null. Then, each null-velocity instant is classified as a candidate start/end time or a candidate peak time. Then, a start time, end time and peak time for each iteration are determined as a combination of two candidate start/end times and a candidate peak time that fulfils certain conditions on the values of the rotation signal in correspondence of candidate start/end times and candidate peak times.

The invention relates to a method of testing an infant, comprising the following steps: displaying a target on a screen; detecting contact made by the infant with the screen inside and/or outside the target; calculating a success parameter on the basis of the contact detected; and recording the calculated success parameter in a memory.

A system for monitoring a movement disorder includes a movement detector configured to track at least one point of reference in three dimensions, and a computing device communicatively coupled with the movement detector. The computing device is configured to receive movement data associated with the at least one point of reference over a period of time, perform a kinematic data analysis based on the movement data, compute a weighted score using the kinematic data analysis, compute a trend based on historical movement data, the weighted score and the trend being associated with the movement disorder, and display the weighted score, the trend and the movement data on a display associated with the computing device.

A device and method is provided for stimulation of neurons. The device includes a stimulation unit that can be implanted into a body of a patient and has stimulation elements that apply a stimulation signal to tissue of the patient to stimulate neurons in the brain and/or the spinal cord of the patient. Moreover, a measuring unit receive a measurement signal that reflects a neuronal activity of the stimulated neurons. Further, a control unit generate a modulation signal from the measurement signal, and modulates an amplitude of a pulse train with the modulation signal. Individual pulses of the pulse train include a first and second pulse portions that introduce and remove charge from the tissue. Moreover, the control unit varies a pause between the pulse portions until the synchronization of the stimulated neurons is minimized or falls below a predetermined threshold.