Introduced here are techniques for digitally characterizing the movement of a subject in order to detect the presence of a disorder or monitor the progression of the disorder. More specifically, one or more angular features can be identified that define how certain part(s) of the human body move relative to other part(s) of the human body. These angular feature(s) can be used, for example, to affirmatively diagnose instances of a disorder, eliminate a disorder as the source of symptoms experienced by a subject, generate confidence scores that can be used to assist in diagnosing a subject, monitor disorder progression due to treatment or lack thereof, etc.

Systems and methods for tracking unintentional high amplitude muscle movements of a user and stabilizing a handheld tool are described. The method may include detecting motion of a housing of the handheld tool when manipulated by a user while the user is performing a task with a user-assistive device attached to an attachment arm of the handheld tool, and storing the detected motion in a memory of the handheld tool as motion data. Furthermore, the method may include controlling a first motion generating mechanism and a second motion generating mechanism by generating a first motion signal and a second motion signal that respectively drive the first motion generating mechanism in a first degree of freedom and the second motion generating mechanism in a second degree of freedom to stabilize motion of the user-assistive device attached to the attachment arm of the handheld tool.

A system for obtaining and analyzing data for overall joint motion from a plurality of joints of a subject experiencing a movement disorder involves a plurality of kinematic sensors configured to be placed on a body of a subject experiencing a movement disorder proximal a plurality of joints of the subject. The kinematic sensors are selected to measure overall joint motion with sufficient degrees of freedom for individual joints so that data collected by the sensors can be deconstructed into multiple degrees of freedom for individual joints and analyzed to provide amplitude of the movements caused by the movement disorder and/or relative contributions from and/or directional bias for each muscle group that may be implicated in the movement of each joint. Such a system permits methods for determining a treatment regimen for treating the movement disorder, whereby the treatment regimen is based on the amplitude of the movements and/or the relative contribution and/or directional bias of each muscle group to the movements caused by the movement disorder.

The invention provides dosage regimes for treatment of synucleinopathies. In one regime, a subject receives 3000-5000 mg of an antibody intravenously every 3-5 weeks. In another regime, a subject receives 1300-1700 mg of an antibody intravenously every 3-5 weeks.

A method of assessing the likelihood that an individual has impulse control disorder. The individual is provided with an actuator, and instructed to actuate the actuator as an acknowledgement of when the individual has completed a reward task. Actuation of the actuator is monitored and recorded. An automated diagnosis of ICD is produced and output, wherein a greater degree of actuation of the actuator by the individual is taken to indicate a greater likelihood that the individual has impulse control disorder.

In one example, a system for measuring body movement is provided. The system may comprise at least one processor and a memory storing processor executable codes, which, when implemented by the at least one processor, cause the system to perform operations comprising, at least receiving a video including a sequence of images and detecting at least one object of interest in one or more of the images. Feature reference points of the at least one object of interest are located, and a virtual movement-detection framework is generated in one or more of the images. The operations may include detecting, over the sequence of images, at least one singular or reciprocating movement of the feature reference point relative to the virtual movement-detection framework and generating a virtual path tracking a path of the at least one detected singular or reciprocating movement of the feature reference point.

Treatment with 2-amino substituted nicotinamides or their salts ameliorates the cognitive and motor dysfunction associated with Angelman Syndrome (AS).

A method of simulating a tremor in a subject and evoking an empathetic response in the subject towards a patient suffering from tremors, the method comprising: synthesizing a tremor inducing signal, which may be done by capturing and analyzing EMG measures of electrical pulses derived from a sensed neuromuscular event associated with tremors experienced by a patient; and applying an electrical muscle stimulation to the subject using the synthesized pulses associated with the patient experiencing tremors.

In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

A method of diagnosing a disorder includes obtaining a medical image of a subject. A Helmholtz Minimum Free Energy is computed from the medical image. A negative slope of the Helmholtz Minimum Free Energy is determined, from which a glial force is computed. The existence of a disorder in the subject is diagnosed if a value of the glial force is within a predetermined range. The disorder can be, for example, a brain disorder, such as Alzheimer's disease, Parkinson's disease, and/or schizophrenia. Other examples of disorders are epilepsy and rheumatoid arthritis. The subject can be, for example, a human subject.