Computational models and methods and systems of using the model to estimate variable time delay in the sensorimotor system of a subject are provided. The computational model can estimate variable time delays in the sensorimotor system, predict sensory states based on delayed sensory feedback, and/or control the system in real time. The subject can be a human or a primate. Simulation experiments can show how the model can explain a sensorimotor system's ability to compensate for delays during online learning and control.

A system and method for the assessment and therapeutic treatment of neurologic function deficits through the evaluation of voluntary and involuntary neuromuscular activity and voluntary neuromuscular responses made on demand as a response to a cognitive skills test. The system permits the remote assessment and therapy of a patient through prescribed physical and cognitive skills regimens either through the remote direction of a therapist or through an artificial intelligence system that selects and modifies regimens based upon the analysis of historical data and/or real-time data. The combination of physical and cognitive therapy to require physical responses to cognitive queries is believed to improve patient outcomes by slowing, halting, or reversing the progression of certain neurological deficits.

Embodiments of the present invention provide systems and methods for analyzing cognitive status. The method includes capturing a set of observables for a subject based on their interaction with smart objects, such as smart blocks or smart items. The method further includes accessing data sets, such as medical data about cognitive function, scientific data about cognitive function, and historical data for the subject, analyzing the set of observables, and generating a report about the cognitive abilities of the subject based on the analysis.

Embodiments of the present invention provide systems and methods for analyzing cognitive status. The method includes capturing a set of observables for a subject based on their interaction with smart objects, such as smart blocks or smart items. The method further includes accessing data sets, such as medical data about cognitive function, scientific data about cognitive function, and historical data for the subject, analyzing the set of observables, and generating a report about the cognitive abilities of the subject based on the analysis.

Embodiments of the present invention provide a circuit board enclosed in an encasing with processors and memory, configured to receive and analyze data, and containing computer logic capable of receiving and analyzing data. The apparatus further includes sensors connected to the processors configured to transfer data to the processors, a power source configured to provide power to the processors, memory modules and sensors, one or more of a light source, an audio source, a vibration source, and a video source, a timing device, a wireless component and/or a wired component capable of transferring data, a light sensor capable of determining the intensity of the received light, computer logic capable of generating a report or transferring the data to a source capable of generating the report, where the report is a cognitive assessment, a comparison of cohorts, or a determination of how the subject puts together more an apparatus with a second apparatus, and where the cohorts are people with same or similar diseases, conditions, ages, medical histories, social demographics, experience levels, or locations.

The present disclosure provides methods and devices for assessing movement. In some exemplary embodiments, a system for assessing movement is provided. In some embodiments, the system includes a handheld device. In some embodiments, the handheld device includes a plurality of sensors configured to record motion and position data, a body having a plurality of sides, a battery, and a proximal end configured to interact with a touchscreen of a computing device.

Embodiments may provide multimodal diagnostic systems and methods for detecting neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, PTSD, schizophrenia, dementia and many others. For example, a system for monitoring brain activity may comprise a plurality of sensors, each adapted to monitor a physical or physiological parameter and output a signal representing the monitored physical or physiological parameter, wherein the plurality of sensors includes at least one sensor configured to monitor a brain activity parameter, a data collection device adapted to receive the plurality of signals from the plurality of sensors and to process the signals to form digital data representing the monitored physical or physiological parameters, and a data processing device adapted to process digital data representing the monitored physical or physiological parameters to determine presence of a neurological disorder or condition.

A method for automatically assessing information processing speed in a test subject is disclosed. In the inventive method, a first qualimetric activity parameter for sensorial transmission, cognition and motoric output activity is determined and a second qualimetric activity parameter for sensorial transmission and motoric output activity is determined. A third qualimetric activity parameter for cognition is determined by comparing the first and the second qualimetric activity parameters to each other, and the information processing speed in the test subject is assessed based on the first, second and third qualimetric activity parameters. The information processing speed can be determined by comparing the determined qualimetric activity parameters to a reference and the subject's cognitive impairment can then be determined from the processing speed. The inventive method can be computer implemented. A mobile device or system for carrying out the disclosed methods is also disclosed.

Various embodiments provide a synuclein signature for distinguishing multiple system atrophy (MSA) from Parkinson's disease (PD) in a patient, the synuclein signature comprises a quantitation of total P-SYN across a posterior cervical biopsy site, a distal thigh biopsy site, and a distal leg biopsy site, and a distribution coefficient of P-SYN across the posterior cervical biopsy site, the distal thigh biopsy site, and the distal leg biopsy site.

A controller and associated multi-axis sensor system for augmenting the automatic intelligent delivery of one or more drugs is provided. The controller and associated multi-axial sensor system are based on the detection and determination of particular physical lifestyle events. As a specific example, a pump augmentation system includes a six-axis accelerometer sensor, a gyroscopic pitch sensor and a controller. The controller is configured to receive motion data from the six-axis accelerometer sensor and orientation data from the gyroscopic pitch sensor. The controller provides a pump instruction signal for changing a delivery rate of a drug to a user based on the motion data and the orientation data. The system and methods are particularly suited for treating a user with Parkinson's disease.