A method, which is for assessing drowsiness of a subject over a period of time, includes the steps of: acquiring gaze and blink measurements of the subject over a period of time; and statistically comparing the measurements against a plurality of gaze and blink measurements, which have been correlated to alertness, in order to produce a value representative of alertness/drowsiness.

Methods are provided for measuring glio-vascular pathway (glymphatic system) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance.

The present invention relates to an automated method of determining a kinetic state of a person. The method obtains accelerometer data from an accelerometer worn on an extremity of the person and processes the accelerometer data to determine a measure for the kinetic state. The present invention further relates to a device for determining a kinetic state of a person. The device comprises a processor configured to process data obtained from an accelerometer worn on an extremity of the person and to determine from the data a measure for the kinetic state. In the method and system the kinetic state is at least one of bradykinesia, dyskinesia, and hyperkinesia.

The present disclosure provides a wearable device for the detection of mild traumatic brain injury, such as concussions, and methods of use thereof. Further disclosed are a method and system for detecting a mild traumatic brain injury.

Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.

A device with a non-invasive first stimulation unit configured to generate first stimuli which, when administered to a patient, suppress a pathologically synchronous activity of neurons in at least one of the brain and the spinal cord of the patient, with a non-invasive second stimulation unit configured to generate at least one of optical, acoustic, tactile, vibratory, and thermal second stimuli, and with a control unit configured to control the first and second stimulation units, wherein the generation of the first and second stimuli takes place optionally in a first or a second operating mode, and the control unit is configured to control the first and second stimulation units in such a way that, in the first operating mode, the generation of at least 60% of the second stimuli is coupled in time to the generation of the first stimuli and, in the second operating mode, the generation of at least 60% of the second stimuli takes place without the generation of the first stimuli.

The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a drug delivery system for dosing a subject in response to the increased severity of a subject's symptoms. The present invention provides for a system and method, which can accurately quantify symptoms of movements disorders, accurately quantifies symptoms utilizing both kinetic information and electromyography (EMG) data, that can be worn continuously to provide continuous information to be analyzed as needed by the clinician, that can provide analysis in real-time, that allows for home monitoring of symptoms in subject's with these movement disorders to capture the complex fluctuation patterns of the disease over the course of days, weeks or months, that maximizes subject safety, and that provides remote access to the clinician or physician.

The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a treatment delivery system for treating a subject in response to changes in the severity of a subject's symptoms. The present invention further provides for a system and method, which can accurately quantify symptoms of movement disorders, utilizing continuously obtained kinetic information to be analyzed, accurately distinguishing between symptoms of movement disorders and activities of daily living, relating quantified symptoms to a standard clinical rating scale, and correlating a subject's symptoms with certain physiological and environmental factors. The present invention still further provides for home monitoring of symptoms in subjects with these movement disorders in order to capture the complex fluctuation patterns of the disease over the course of days, weeks, months, or years.

A device for stimulating neurons that includes a stimulation unit that applies mechanically tactile and/or thermal stimuli to the body surface of a patient that stimulate neurons with a pathologically synchronous and oscillatory neural activity. The device includes a measuring unit that records measurement signals of neural activity of the stimulated neurons, and a controller that controls the stimulation unit and analyzes the measurement signals. The controller actuates the stimulation unit to scan at least one part of the body surface of the patient along a path and thereby periodically applies stimuli and also selects two regions or more regions on the patient's body surface along the path where the phase synchronization between the periodic application of the stimuli and the neural activity of the stimulated neurons have a local maximum using the measurement signals. The stimuli are then applied in a delayed manner in the two regions.

A medical evaluation system includes an I/O module, a processing module, and an analysis module. The I/O module receives sensory data obtained by a motion sensor disposed in a mobile device carried by a patient at least when the patient is in a non-clinical environment. The processing module extracts medically relevant data from the sensory data received from the sensor in the mobile device. The relevant data includes one or more features of interest in the sensory data. The analysis module derives one or more surrogate biomarkers from the relevant data. The surrogate biomarkers represent at least one of a state or a progression of a medical condition of the patient. The mobile device may be a mobile phone carried by the patient and the sensor may include at least one of an accelerometer or a gyroscope that generates the sensory data to represent movements of the patient.