A method for a user unit, a user unit and a system comprising said user unit. A unit (10) comprising a task manager (11) arranged to control the user unit; a communication interface (12) arranged in connection with task manager (11) and arranged for communication with an external device; one user interface (13) disposed in communication with the task manager (11) and adapted for communication with a user; a real-time interpreter (14) arranged in said communication task manager (11) and in communication with an instruction memory (15) and a data memory (16) and adapted to interpret event definitions, query lists, and at least a predefined schedule stored in the user units instruction memory (15); a real time clock (17) arranged in communication with the task manager (11) and arranged to continuously update the time, the task manager (11) is arranged to control communication with an external device and/or a user based on interpretations of the interpreter makes the event definitions, query lists, and the at least one predefined schedule, and based on the current time.

A system and method for assessing patient movement for Parkinson's disease includes capturing a video of a subject performing a finger tapping sequence comprising a predetermined number of open and close periods. According to an exemplary embodiment, a system and method includes extracting a region of interest for each frame of the video and generating a projection of the region of interest for each frame of the video using perpendicular vector projections in a direction or plurality of directions.

A wearable system including a controller and a plurality of wearable components configured to communicate with the controller is described. The controller performs a frequency analysis of music and sends control information to at least some of the wearable components based on the frequency analysis. The plurality of wearable components include at least one auditory stimulator configured to provide air conduction stimulation to the user, a plurality of vestibular stimulators configured to provide bone conduction stimulation to the user. The wearable system also includes at least one motion sensor configured to sense motion information, and at least one sympathetic arousal sensor configured to sense sympathetic arousal information of the user during stimulation by the plurality of vestibular stimulators. The controller is configured to adjust the control information based, at least in part, on the sensed motion information and/or the sensed sympathetic arousal information received from the sensors.

The present invention relates to a non-invasive system with diagnostic and treatment capacities that use a unified code that is intrinsic to physiological brain function. In an embodiment of the present invention, an approach to the treatment of disorders that supplements existing diagnostic and treatment methods with robust quantitative data analysis are presented. This is achieved by a unification of cognitive and neural phenomena known as the Fundamental Code Unit (FCU), representing identifiable patterns of brain activity at the submolecular, molecular, and cellular levels (intra-brain communications), as well as their manifestations in thought and language (inter-brain communications).

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

Methods and systems for monitoring compliance of a patient with a prescribed treatment regimen are described. Patient activity is detected unobtrusively with an activity sensor at the patient location, and activity data is transmitted to a monitoring location. Patient speech detected during use of a communication system such as a mobile telephone by the patient may also be used as an activity signal. Patient activity and/or speech is processed at the patient location or monitoring location to identify activity parameters or patterns that indicate whether the patient has complied with the prescribed treatment regimen. The activity sensor and other components at the patient location may be incorporated into, or associated with, a cell phone, computing system, game system, or vehicle system, for example. The system may provide a report to an interested party, for example a medical care provider or insurance company, regarding patient compliance with the prescribed treatment regimen.

A medical device delivers a therapy to a patient. The medical device or another device may periodically determine an activity level or gait parameter of the patient, and associate each determined level or parameter with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels or parameters associated with that therapy parameter set. Whether the patient is currently experiencing or anticipated to experience gait freeze caused by their neurological disorder, such as Parkinson's disease, may also be determined. Gait freeze events may be associated with current therapy parameters and used to determine activity metric values. In some examples, the activity metric associated with certain therapy parameters may be presented to a user.

Systems and methods are disclosed to detect and/or classify electrophysiological signals as motor events. In some embodiments, a method may include: recording a first plurality of electrophysiological signals from a first plurality of probes inserted into the left hemisphere of the brain; recording a second plurality of electrophysiological signals from a second plurality of probes inserted into the right hemisphere of the brain; pre-processing the first plurality of electrophysiological signals and the second plurality of electrophysiological signals; bipolar re-referencing the first plurality of electrophysiological signals and the second plurality of electrophysiological signals; determining an optimal pair of electrophysiological signals from the bipolar re-referenced first plurality of electrophysiological signals and the bipolar re-referenced second plurality of electrophysiological signals; matching the optimal pair of electrophysiological signals with a template; and detecting motor events from the matching.

This invention provides a method for treating or for reducing ambulatory deterioration in a human patient diagnosed to be afflicted with relapsing-remitting multiple sclerosis (RRMS) and having a high baseline disability score according to the Kurtzke Expanded Disability Status Scale (EDSS), comprising periodically administering to only the patient diagnosed with RRMS and having a high baseline disability score an amount of laquinimod effective to treat the patient or to reduce ambulatory deterioration. This invention further provides pharmaceutical compositions and packages comprising an effective amount of laquinimod for treating a human patient diagnosed to be afflicted with RRMS and having a high baseline disability score according to the EDSS.

The disclosure provides a method for performing automated visual motor response assessment by receiving motor response input responsive to presenting visual stimulation, the method including: presenting a scene to a subject on a display; modulating contrast of a predetermined section of the scene; moving the predetermined section relative to the scene; providing a manual input device for tracking movement of the predetermined section; receiving tracked movement data from the manual input device; measuring a kinematic parameter of the tracked movement data; quantitatively refining the tracked movement; determining a relationship between at least one of the scene and quantitatively refined tracked movement; adjusting modulated contrast relative to the quantitatively refined tracked movement; and calculating a critical threshold parameter in relation to a subject.