The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.

An apparatus that can measure images of at least a portion of an eye and record data sets indicative of a neurological condition. A method interrelates an image and a data set to provide an interpretive result. The apparatus and method thereby provide guidance as to the presence of a medical condition in a patient. The apparatus and method can be used in an iterative measurement process, in which the apparatus attempts to discern normal health from a state of health that is not normal health. If the interpretive result is consistent with normal health, the process terminates, information is recorded, and an optional report is given. If the interpretive result is not consistent with normal health, the apparatus and method attempts to distinguish which condition is consistent with the data and images used, and can iterate with additional measurements and information to attempt to provide a useful interpretive result.

A drug infusion system located at least partially external to the patient having a pump and a patient programmer control configured to present to the patient a question and receive patient input information in response thereto. A patient response rule module is configured to apply a rule to the input information provided by a patient. For example, the patient response rule can be used to provide an insulin pump setting according to the patient response rule or to provide a setting, or to provide a setting that is proposed to the user. Other systems and methods are also described such as asking questions related to the adjustment of future therapy settings.

A cognitive and/or motor skill testing system and method may include a processor that records respective time information for each of multiple positions of a display device that are traced during administration of a test, that determines speed and/or velocity values based on the recorded time information, and that outputs test result information based on the determined values. The test result information may be based on a comparison between a graphed curve of such values to an ideal curve. The positions may correspond to a path between displayed targets whose size and/or distance therebetween depend on past test performance. The system and/or method may output a change expected with a change to therapy parameters for a patient, where the expected change is determined based on changes which occurred in other patients having similar test results and therapy parameters as those of the patient.

Detection of neurological diseases such as Parkinson's disease can be accomplished through analyzing a subject's speech for acoustic measures based on human factor cepstral coefficients (HFCC). Upon receiving a speech sample from a subject, a signal analysis can be performed that includes identifying articulation range and articulation rate using HFCC and delta coefficients. A likelihood of Parkinson's disease, for example, can be determined based upon the identified articulation range and articulation rate of the speech.

A system and method for measuring and analyzing locomotion is provided. The system may include a gait analysis apparatus that is configured to provide multi-dimensional measurements of the gait of an individual as the individual traverses the apparatus. The multiple dimensions may include force, space, time, and frequency. The gait analysis apparatus may be configured to provide a gait measurement processing device with the multi-dimensional measurements. Based on the multi-dimensional measurements, the gait measurement processing device may, for example, diagnose the test subject with a particular NM disease and/or injury, monitor progression of the particular NM disease and/or injury over time, and determine which measurements may be used as biomarkers to identify the particular NM disease and/or injury.

Systems and methods are provided for measuring electrical activity within a brain of a patient. An electrode array is configured to take measurements of electrical potential as raw electroencephalographic (EEG) data. A data processing component includes a spectral decomposition component configured to divide the raw EEG data into a plurality of frequency intervals, within a total range of frequencies and an inverse solution component configured to transform the raw EEG data associated with each frequency interval into a spatial mapping of electrical activity as to provide a set of parameters, with each parameter representing an average electrical activity at an associated location within the brain over an epoch of interest.

Systems and processes for measurement of the eyelid movements of a subject, which explores eyelids' electrical conductivity, namely the established fact that eyelids are acting as sliding electrodes moving over the cornea, is comprised of a system for generating a high frequency weak and harmless oscillating electromagnetic field in the proximity of the eyelid movement path without interference with the vision or activity of any such subject, therefore induces so-called Eddy Currents in the eyelid, which in its turn produce its own electromagnetic field with a value depended on the eyelid position; the interaction between the basic oscillating electromagnetic field and the field generated by the eyelid is changing electromagnetic field inductance, which will be measured with very high accuracy by means of resonance sensing electronics; such systems can transmit data from its detecting electronics to a remote monitor that compels no restrictions on operator activity.

Methods are provided for non-invasive early screening of a subject for a neurodegenerative disorder, by analyzing one or more parameters associated with the neurodegenerative disorder.

Methods and systems are disclosed for sensing and assessing a patients responses to tests using a device that may include tactile input, voice input, still image analysis, and responses to visual and auditory stimuli. In one example, a method includes obtaining interactive clinical assessment data using a remote client device and a computer-based control device, the method including providing on a display of a remote client device one or more test prompts for conducting an interactive clinical assessment, each displayed test prompt instructing a user to perform an action using the remote client device in response to the test prompt, and providing on the display of the remote client device one or more potential responses of actions that may be performed in response to the test prompt.